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The chloroplast-localized small heat shock protein (sHsp) Hsp21 belongs to the family of alpha-crystallin like sHsps which form large oligomeric structures and protect partly unfolded aggregation-prone proteins against aggregation. The main focus for this thesis has been on the highly conserved methionines in Hsp21. These methionine residues are situated on one side of an amphipathic alpha-helix.
The Class Aves (birds) is generally divided into two main groups - the Palaeognathae and the Neognathae. Paleognathous birds are the flightless ratites and the tinamous, while Neognathae include all other extant birds (more than 9,000 species). This opinion has prevailed for more than a century and is primarily based on morphological studies of the avian bony palate. In this study, the relationsh
Abstract The efficiency of different leachate treatment methods for the removal of refractory organic compounds and ammonium-nitrogen was investigated. The methods evaluated were nitrification, denitrification, adsorption onto activated carbon, precipitation by ferric chloride or aluminum sulphate and oxidation by ozone or Fenton´s reagent. Furthermore, analyses were performed on leachates from mu
Two non-thermal regimens of light interaction with biological tissue, that are in a natural way connected, are discussed in the present thesis. These are photodynamic therapy (PDT) for the treatment of malignant tumours and laser-induced fluorescence (LIF) for tissue characterization. In PDT, a photochemical reaction is induced by non-ionizing electromagnetic irradiation in tissue where photosens
In my research, I have explored various aspects of acetals and their reactivity. Acetals have a central role in carbohydrate chemistry as an inherent functionality and as versatile protecting groups. The first part of the thesis summarizes results on regioselective reductive openings of benzylidene acetals. We thus used deuterium substituted benzylidene acetals and boranes, to investigate stereose
The overall aim of this composite thesis, consisting of five articles, is to develop concepts for furthering the understanding of small business managers´ handling of finance. The main contribution is the development of a conceptual understanding of so-called financial bootstrapping behavior in small businesses (referring to the use of methods for minimizing and/or eliminating the need for financi
Degradation of mRNA is a controlled process which is as important for gene regulation as the synthesis of mRNA. This thesis focuses on mechanisms of mRNA stability and degradation in Bacillus subtilis, the model of Gram-positive bacteria. The aprE mRNA, encoding an exported protease named subtilisin, is extremely stable with a half-life of more than 25 minutes. Average mRNA half-lives in B. subtil
The neutrophil store its effector proteins in several distinct types of cytoplasmic granules, developed sequentially during cell maturation. The different subtypes of granules have unique protein content and functional characteristics. The formation of each granule subtype coincides with the biosynthesis of its content. Granule proteins synthesised during the formation of a granule subtype are thu
Falls and fractures in older people are a common and increasing health problem which causes physical, social and psychological problems for the individual and is costly to society. The aims of this thesis were to investigate accidental falls of patients aged 65 - 74 who attended an orthopedic emergency ward, to investigate reliability of the modified figure of eight (MFE) and compare it with other
The topic of this dissertation is the work of the poet Bruno K. Öijer (b. 1951). My thesis is, that a recognition of how he has assumed the outsider position is vital for an understanding of his work, and that it also may contribute to an explanation of his particular importance in the cultural arena of the early 70s. The thesis is structured in four parts. Part one deals with the concept “outside
Two polymers, alginate and Eudragit S-100 were used as reversibly soluble-insoluble ligand carriers for the selective isolation of enzymes and lectins respectively. These two polymers have the inherent property of being precipitated under well defined conditions. Alginate was made insoluble by the addition of Ca2+ ions, and Eudragit S-100 by a pH shift. The polymers were modified with affinity lig
Infectious pancreatic necrosis virus (IPNV) is a Birnavirus that infects salmonid fish. The infection is usually mortal for fish under six months of age, while older fish become carriers, usually without any signs of infection, and will spread the virus to other susceptible fish and to their offspring. IPNV is an icosahedral, naked virion and the genome consists of two segments of double-stranded
Organizational creativity and psychological well-being. Present day organizations in a globalized society are experiencing external challenges and changes more than ever before and in order to adapt and react to these changes creativity and innovation are seen as some of the most important means. The standpoint in this thesis is that all employees have creative potential, and how the creative pote
Interactions of proteins with other proteins, with polymers and with surfaces are of great practical importance within for instance protein purification, drug delivery, and food technology. The aim of this work is to increase the understanding of protein-protein, protein-polyelectrolyte, and protein-surface interactions, particularly concerning the role of electrostatic interactions in these syste
This thesis in industrial design concerns the challenges and possibilities in meeting demographic shifts and the presumed expectations of today’s and tomorrow’s older generations. The background is the lack of furniture that responds to the demands of older consumers and the lack of knowledge about relationships between people and furniture in their home environments and in various forms of elderl
Helicobacter pylori is a gastric pathogen colonising the gastric mucus layer and epithelium of gastric tissue and is associated with chronic type B gastritis and peptic ulcer disease. The attachment of H. pylori to gastric epithelial cells involves several structures recognised by specific bacterial surface proteins. Since colonisation is an initial and critical step in the development of a chroni
Thermal endometrial destruction by means of a silicone balloon catheter is a new form of treatment for menorrhagia aimed at reducing menstrual blood loss. The purpose of the present work was to study, experimentally, the thermal effects on and the thermal conductivity of uterine tissue, to obtain a basis for the estimation of optimal treatment conditions by means of numerical analyses using a comp
All viruses that infect bacteria, plant, or animal cells involve a genome (RNA or DNA) that is encapsidated by a rigid protein shell. After delivery of the viral genome into the host cell, new capsid proteins, which are encoded by viral DNA or RNA, are expressed and self-assembled into new viral capsids. The main objective of my research was to study the key physical factors of genome ejection tha
The biological response to different implanted biomaterials vary. The relative importance of factors in the material and host for this variation are at present incompletely known. The variation in the cellular response to specific proteins and the rapid adsorption of proteins to surfaces exposed to biological environments has created the hypothesis that the cellular interactions with biomaterials
The central phenomenon investigated concerns the valence-based process asymmetry found in several earlier studies (e.g. Pratto & John, 1991; Taylor, 1991), where negative stimuli seem to initiate more thorough processing than positive stimuli. This finding was consistent in the three empirical studies forming this dissertation. In Study 1 (three experiments) emotionally valenced words were pre
