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Haplotypes in the CYP2R1 gene are associated with levels of 25(OH)D and bone mineral density, but not with other markers of bone metabolism (MrOS Sweden)

Objective Polymorphisms in the CYP2R1 gene encoding Vitamin D 25-hydroxylase have been reported to correlate with circulating levels of 25-OH vitamin D3 (25(OH)D). It is unknown whether these variations also affect overall bone metabolism. In order to elucidate the overall associations of polymorphisms in the CYP2R1, we studied haplotype tagging single nucleotide polymorphisms (SNPs) in the gene a

High seroprevalence of Babesia antibodies among Borrelia burgdorferi-infected humans in Sweden

In northern Europe, tick-borne diseases such as Lyme borreliosis (LB) and tick-borne encephalitis (TBE) are well known. The actual incidence of Babesia infections, however, has remained elusive. In this study, the prevalence of antibodies against two Babesia spp. was investigated in a cohort of patients that were seropositive for Borrelia (B.) burgdorferi sensu lato (s.l.). Data were compared to a

Selecting Ministers in Times of Crisis : A Historical Analysis of the Role of Intra-Party Politics and Union Background in Swedish Cabinet Appointments 1917–2014

In this article, we connect intra-party politics to macro events by asking what types of ministers are selected in times of fiscal crisis. Drawing on the previous literature we present two alternative hypotheses about the role of the union background in cabinet selection: (1) ministers with union background are less likely to be appointed during crises, since they are likely to oppose necessary sp

Association of Genetic vs Environmental Factors in Swedish Adoptees with Clinically Significant Tinnitus

Importance: No effective treatments are currently available for severe tinnitus, which affects 1% of the population and lowers the quality of life. The factors that contribute to the transition from mild to severe tinnitus are poorly known. Before performing genetic analyses and determining the mechanisms involved in the development of severe tinnitus, its heritability needs to be determined. Obje

Temporal trends and predictors of perfluoroalkyl substances serum levels in Swedish pregnant women in the SELMA study

Background Perfluoroalkyl substances (PFAS) are used in numerous consumer products. They are persistent, bioaccumulating, and suspected to be endocrine disrupting chemicals (EDCs). A growing body of research has reported the association between PFAS exposure and adverse health effects. Concerns have been raised with special focus in childhood development. Methods Perfluoroheptanoic acid (PFHpA), p

The distinct seasonality of early modern casual labor and the short durations of individual working years: Sweden 1500-1800

Historical wage studies have never been able to truly or accurately address the changes in the working year. Real wages have almost always been based on the wages of unskilled and casual laborers, typically paid by the day. Their annual incomes are not clear or obvious – the income is directly dependent on how many days they work. Implicitly the literature has assumed that the number of days worke