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Din sökning på "julie" gav 4427 sökträffar

Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells

Changes in gene regulation and expression govern orderly transitions from hematopoietic stem cells to terminally differentiated blood cell types. These transitions are disrupted during leukemic transformation, but knowledge of the gene regulatory changes underpinning this process is elusive. We hypothesized that identifying core gene regulatory networks in healthy hematopoietic and leukemic cells

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients : the DecubICUs study

PURPOSE: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients.METHODS: International 1-day point-prevalence study; follow-up for outcome assessment unti

Subclinical atherosclerosis in patients with cyanotic congenital heart disease

Introduction: Survival in patients with cyanotic congenital heart disease (CCHD) has improved dramatically. The result is an ageing population with risk of acquired heart disease. Previous small uncontrolled studies suggested that these patients are protected against the development of atherosclerosis. To test this hypothesis, we sought to determine the prevalence of subclinical atherosclerosis in

Föräldraskapande - En kritisk undersökning av den rättsliga konstruktionen av föräldraskap med särskilt fokus på regleringen av föräldraskap vid ändrad könstillhörighet

Since July 1, 2013, there is no longer a sterilization requirement for transgender persons who want to transition. This paper critically examines the new legislation in the Parental Code, which entered into force on January 1, 2019 as a result of the abolished sterilization requirement. The new legislation applies to parenthood when one or both parents have changed their legal gender. Before the n

Sequence analysis of HIV-1 isolates from Guinea-Bissau: selection of vaccine epitopes relevant in both West African and European countries.

For a CD8 epitope-based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T-lymphocytes (CTLs) must be present in the local circulating HIV-1 strains. Secondly, the vaccine epitopes should match the host population HLA types. We characterized two new HIV-1 isolates from Guinea-Bissau. Also, we have identified 15 subdominant CD8 epitopes representing common HLA su

Clinical characteristics and outcomes of patients with Hodgkin lymphoma with central nervous system involvement : An international multicenter collaboration

Central nervous system (CNS) involvement is rare in patients with Hodgkin lymphoma (HL). Thus, the clinical features and outcomes are not well described. Cases of histologically confirmed CNS HL diagnosed between 1995 and 2015 were retrospectively identified in institutional (n = 7), national (n = 2), and cooperative group (n = 1) databases. We screened 30,781 patients with HL in our combined data

Inspektion av Nation: En kvalitativ studie om intern kontroll och riskhantering i mindre ideella föreningar

Title: Inspection of Nation Seminar date: 2024-05-30 Course: FEKH69, Business Administration: Bachelor Degree Project in Financial and Management Accounting Undergraduate level, 15 ECTS-Credits Authors: Ebba Rysjö Lindholm, Julia Skordby, William Lindh Gråsjö Supervisor: Elin Funck Key Words: Internal Control; Risk Management; COSO-Framework; Financial Irregularities; Non-Profit Organizatio

Flyttningsförbudets förenlighet med barnets bästa – i ljuset av lex lilla hjärtat

Inom den sociala barnavården och familjehemsplaceringar av barn finns det tre grundtankar, kontinuitet, flexibilitet och närhet. Vid en familjehemsplace-ring med stöd av lagen med särskilda bestämmelser om vård av unga ska vår-den vara inriktad på att den unga ska återförenas med sina föräldrar, men det finns undantag. Flyttningsförbudet stadgas i 24 § LVU och ger möjligheten att införa ett förbudIn the field of child welfare there are three fundamental principles: continuity, flexibility and proximity. In the case of a family home placement according to The Care of Young Persons Act, the care must be aimed at reuniting the young person with their parents, but there are exceptions. Prohibition of relocation is regulated in section 24 of The Care of Young Persons Act and pro-vides the possi

Frivillighet i våldtäktsbestämmelsen – mellan lagens bokstav och rättens tillämpning. En analys av frivillighetsrekvisitets tillämpning i praxis efter samtyckesreformen, i ljuset av lagstiftarens intentioner

On July 1st, 2018, a significant reform of Sweden’s rape legislation came into force through the introduction of a consent-based legal framework in Chapter 6, Section 1 of the Swedish Penal Code. This reform marked a paradigmatic shift from coercion-focused regulation toward an emphasis on individual sexual autonomy and voluntary participation. The purpose of this thesis is to clarify and critical

"Big Brother" - En studie om framställandet av sambandet mellan alkohol och skandaler

Det relativt nya fenomenet reality-serier blir allt populärare och upptar en stor del av dagens tv-tablå. Fenomenet tillsammans med övrig massmedia har större inflytande och påverkan på samhället och oss människor än någonsin tidigare. Man diskuterar alkoholens roll i samhället, dess konsekvenser för relationer, hälsa o.s.v. Sedan TV kom har även alkoholens representation i TV kommit att bli en he

Barnfridsbrottet - ändamålsenligt utifrån barnets bästa?

Fysiskt och psykiskt våld förekommer i många hem i Sverige. Allt för många barn växer upp med att få se, höra och uppleva detta våld. Under de senaste åren har forskning tydligt visat att barn som bevittnat våld inom familjen påverkas väldigt negativt. De känner ofta en känsla av maktlöshet, övergivenhet och skam. För att stärka barnets rättsliga ställning har det tidigare införts en straffskärpnPhysical and psychological violence exist in many homes in Sweden. Far too many children have grown up with witnessing, hearing and experience the violence. In recent years research has shown that children who witness violence within the family gets profoundly affected. They often feel a sense of powerlessness, abandonment, and shame. To strengthen the legal position of the child, a basis for aggr

Förslaget om säkerhetsstraff - En kritisk analys mot bakgrund av påföljdsbestämningens grundläggande syften och principer

In July 2024, the Inquiry on Sanctions, Recidivism, and Enforcement submit-ted its report, SOU 2024:48, which includes a proposal to introduce a preventively oriented, indefinite deprivation of liberty as a sanction, referred to as a security sentence. The purpose of the proposal is to enable the indefinite detention of an offender in particularly serious situations, where the sanction cannot be d

Konformitetsprincipens gränsmarker - Med inriktning mot unga lagöverträdare och en sänkning av straffmyndighetsåldern

Konformitetsprincipen är den grundläggande rättsprincipen i den straffrätts-liga ansvarsläran som ger besked om att den som inte hade förmåga eller tillfälle att kunna rätta sig efter lagen inte bör bli straffrättsligt ansvarig för ett brott. Detta eftersom ett straffansvar i den situationen hade varit orätt-färdigt och meningslöst. Den som inte kunde rå för sin brottsliga gärning ska således inteThe Conformity Principle is a fundamental legal principle within the Swedish system of criminal liability that states that those who did not have capacity or opportunity to act in accordance with the criminal law should not be punished for a crime. Numerous rules and several legal principles can be derived from The Conformity Principle. The rationale behind the Conformity Principle is that it woul

Strävan efter en skyndsam handläggning på bekostnad av VBU-utredningarnas kvalitet? - En studie beträffande effekterna av tidsinskränkningen i 6 kap. 19 § tredje stycket föräldrabalken

På senare år har det skett en bred förskjutning i synen på barn- och föräldrarätt. Ett starkare barnrättsperspektiv har etablerats inom svensk rätt och politik. Flera ändringar har gjorts i föräldrabalken. En av dessa ändringar återfinns i 6 kap. 19 § tredje stycket föräldrabalken. I proposition 2020/21:150 föreslog den dåvarande regeringen en lagstadgad tidsgräns på fyra månader när det kommer tiIn recent years, there has been a broad shift in the view of children’s and parental rights. A stronger children’s rights perspective has been established within Swedish law and politics. Several amendments have been made to the Children and Parents Code. One of these amendments can be found in Chapter 6, Section 19, third paragraph of the Children and Parents Code (sw. föräldrabalken (1949:381)).

IFRS 15 - Full eller modifierad retroaktiv tillämpning? En studie om standardens effekter och faktorer bakom företags val av övergångsmetod

Abstract Title: IFRS 15 - Full or Modified Retrospective Application? A study of the standard’s effects and the factors behind companies’ choice of transition method. Seminar date: June 2nd, 2021 Course: FEKH69, Degree Project Undergraduate level, Business Administration, 15 University Credits Points (ECTS) Authors: Julia Baeza, Vendela Barth and Felicia Sonesson Advisor: Kristina Artsberg Key wor

Barnens utökade rätt i samhället – Från vittnen till målsäganden

On the first of July, 2021, it became a crime in Sweden to allow children to witness crimes between relatives. The crime is called ”barnfridsbrott” and exists in Chapter 4, Section 3 in the Swedish Criminal Code. The criminalization of allowing children to witness crimes between relatives was met with a positive response from most of the consultation bodies. Although it was welcomed with open arms

Tysta leken börjar nu – den som pratar åker ut? En rättsanalytisk uppsats om hur det nya kronvittnessystemet kommit till uttryck i Högsta domstolens prejudikatbildning

As a result of the increased gang violence in Sweden, a crown witness system was introduced on July 22, 2022, which has been widely criticized. However, the legislator considered such regulation to be predominantly necessary. By introducing a new paragraph, ch. 29 § 5 a in the Swedish Criminal Code, the legislation can be described as an attempt to escape the culture of silence and initiate an eff

Radiosynthesis, biological evaluation and preliminary microPET study of 18F-labeled 5-resorcinolic triazolone derivative based on ganetespib targeting HSP90

Heat-shock protein 90 (HSP90) is a molecular chaperone that activates oncogenic transformation in several solid tumors, including lung and breast cancers. Ganetespib, a most promising candidate among several HSP90 inhibitors under clinical trials, has entered Phase III clinical trials for cancer therapy. Despite numerous evidences validating HSP90 as a target of anticancer, there are few studies o