Filtyp
Importance: Novel plasma biomarkers, especially phosphorylated tau (p-tau), can detect brain tau aggregates in Alzheimer disease. Objective: To determine which plasma biomarker combinations can accurately detect tau pathological brain changes in Down syndrome (DS). Design, Setting, and Participants: The cross-sectional, multicenter Alzheimer's Biomarker Consortium-Down Syndrome study included adul
The provision and administration of high quality urban public green spaces intertwines issues of planning, design, management and maintenance with governance. The benefits of such spaces are often tied to social justice, public health and recreation, biodiversity and helping cities to deal with climate change. International policies and changes in public administration have encouraged user partici
Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. Patients with relapsed disease have a poor prognosis despite intense treatment. In the present study, we aimed to identify chemoresistance gene expression signatures in vincristine resistant neuroblastoma cells. We found that vincristine-resistant neuroblastoma cells formed larger clones and survived under reduced ser
The balance between self-renewal and differentiation is crucial for the maintenance of hematopoietic stem cells (HSCs). Whereas numerous gene regulatory factors have been shown to control HSC self-renewal or drive their differentiation, we have relatively few insights into transcription factors that serve to restrict HSC differentiation. In the present work, we identify ETS (E-twenty-six)-related
One of the major roles of seminal plasma is to provide antimicrobial protection for the spermatozoa in the female reproductive tract. We found that the bactericidal activity of seminal plasma was highest after resolution of the seminal clot and that this antibacterial activity subsequently became greatly diminished. The antibacterial activity was derived from peptides generated by fragmentation of
In a warming climate, mercury (Hg) pathways in the Arctic can be expected to be affected. The Hg transport from the high arctic Zackenberg River Basin was assessed in 2009 in order to describe and estimate the mercury transported from land to the marine environment. A total of 95 water samples were acquired and filtered (0.4 mu m pore size), and Hg concentrations were determined in both the filter
Does sertraline provide symptomatic relief for chronic breathlessness in people with advanced disease whose underlying cause(s) are optimally treated?223 participants with chronic breathlessness (modified Medical Research Council breathlessness scale ≥2) who had optimal treatment of underlying cause(s) were randomised 1:1 to sertraline 25-100 mg (titrated upwards over 9 days) or placebo for 4 week
Chronic Obstructive Pulmonary Disease (COPD) is often caused by smoking and other stressors. This causes oxidative stress, which induces numerous changes on both the transcriptome and proteome of the cell. We aimed to examine if the endomembrane pathway, including the endoplasmic reticulum (ER), Golgi, and lysosomes, was disrupted in fibroblasts from COPD patients as opposed to healthy ever-smoker
Membrane proteins (MPs) constitute a large fraction of the proteome, but exhibit physicochemical characteristics that impose challenges for successful sample production crucial for subsequent biophysical studies. In particular, MPs have to be extracted from the membranes in a stable form. Reconstitution into detergent micelles represents the most common procedure in recovering MPs for subsequent a
This paper reports and demonstrates a packetponder for access/metro node consolidation and aggregation using common-form-factor pluggables (CFFP), which can simplify edge network architectures.
INTRODUCTION: In drug facilitated sexual assault (DFSA) the victim is unable to consent to the sexual act due to influence of alcohol, narcotics, or medicine. Increasing the awareness of characteristics associated with DFSA can assist the judicial system in early recognition of cases and guide public health interventions for reducing DFSA. This study aims to assess characteristics of DFSA victims
Uppsatsen behandlar det genomgående motivet av maktkamper i August Strindbergs dramatik. Konflikten är en essentiell ingrediens i praktiskt taget all berättande men Strindberg går ofta längre i sina dramer. Huvudpersonen kämpar mot religionen, andra människor eller sig själv och kampen är en strävan efter makt över motståndaren eller vad den andre parten representerar. Uppsatsen analyser ett anta
Målet för den västafrikanska monetära zonen (WAMZ), som bildats mellan länderna Gambia, Ghana, Guinea, Nigeria och Sierra Leone, är att år 2006 införa en gemensam valuta samt att inrätta en gemensam centralbank. I denna uppsats undersöks om den monetära unionen kan tänkas bli optimal med avseende på de kriterier som härstammar från teorin om det optimala valutaområdet samt huruvida medlemsländerna
I denna uppsats appliceras Fama-Frenchs femfaktormodell på den svenska aktiemarknaden och jag undersöker om det går att ge stöd för att en utökning med en eller två faktorer till Fama-Frenchs trefaktormodell förbättrar förklaringsförmågan till variationen i aktieavkastning. Fama & French (1993) visar att en modell bestående av tre faktorer - marknadsfaktorn, storleksfaktorn och värdefaktorn -
Since the Council Directive (EU) 2016/1164 of 12 July 2016 laying down rules against tax avoidance practices that directly affect the functioning of the internal market (ATAD) and its anti-tax avoidance rules entered into force, the national tax authorities and courts face the task of interpreting and applying national anti-tax avoidance measures in conformity with the directive. However, in the c
The new bill “violation of a child’s integrity” went into force on the 1st of July, 2021 to ensure that more rights for children in criminal law were implemented. The bill was placed in chapter 4 section 3 in the Swedish Criminal Code (1962:700). In the section there is a line up of an exhaustive list of foundation crimes. In order for the violation of a child’s integrity to be able to come into e
I denna studie undersöks kampanjen Nationer mot narkotika. Med utgångspunkt i teorier om narratologi är syftet med uppsatsen att få en ökad förståelse för hur en antidrogkampanj kan säga något om sändarens intentioner, samt granska vilken roll sändaren kan komma att ha i kampanjens framgång. Studiens analysmaterial grundar sig i en kvalitativ metod med tre stycken semistrukturerade intervjuer. Stu
Sexual consent has been discussed for many years. On July 1, 2018, the so-called ”consent law” was introduced into Swedish law. The essay deals with this legislation and how it can make a difference in sexual offense cases where intentions have not been proven. The focus is on relationships where dominance and submissiveness is a lifestyle, or at least one element. Cases will be reported and analy
