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Background: Numerous gene loci are related to single measures of body weight and shape. We investigated if 55 SNPs previously associated with BMI or waist measures, modify the effects of fat intake on weight loss and waist reduction under energy restriction. Methods and Findings: Randomized controlled trial of 771 obese adults. (Registration: ISRCTN25867281.) One SNP was selected for replication i
Kompletthetskravet i MER har varit föremål för diskussion i många år. Det är svårt att tillämpa, svårt att tolka och det är oklart om kompletthetskravet i praktiken ens är behäftat med någon rättsföljd. Samtidigt tycks det vara helt avgörande att på något sätt reglera mängdförteckningars kompletthet, för att systemet med mängdförteckningar över huvud taget ska gå att an-vända. Uppsatsen undersökerThe completeness requirement (“kompletthetskravet”) in MER has been a subject of debate for several years. It is difficult to apply, difficult to interpretet, and it is uncertain whether the completeness requirement is associated with any legal consequence in practice whatsoever. Still, it appears essential to somehow regulate the completeness of bills of quantities (“mängdförteckningar”) for the
Biological diversity faces a global crisis with increasing extinction rates and the loss of variety within species and across ecosystems. Increasingly, large companies are committing to address their impacts on biodiversity, but research shows that corporate reporting remains inconsistent, shallow, and difficult to compare. While biodiversity-related disclosures have largely been driven by various
Urban expansion is a defining feature of rapidly growing cities and has important implications for urban thermal behaviours, particularly in hot and semi-arid regions that are increasingly vulnerable to the effects of climate change. Tripoli, the capital of Libya, has experienced substantial urban growth over recent decades under conditions of weak planning and uneven development. Despite this, th
Uppsatsen syftar till att undersöka hur miljöförsvarare kan skyddas inom EUrätten i utövandet av civil olydnad. Syftet baseras till stor del på- och inspireras av Guidelines on Peaceful Environmental Protest and Civil Disobedience som Specialrapportören för miljöförsvarare under Århuskonventionens nyligen har publicerat. Vidare bygger uppsatsen på ett antal internationella konventioner för att und
This thesis examines how brand positioning of beauty brands, differentiating between high-end and mass-market, influences the engagement rate of consumers on Instagram and TikTok, and explores the role of platform type and content likability in explaining this relationship. As social media continues to shape the way consumers interact with brands, engagement metrics have become key indicators of s
This thesis examines how freedom of expression and misinformation are governed within contemporary digital environments, focusing specifically on the relationship between platform governance on X and international human rights discourse developed by the United Nations Human Rights Council. As social media platforms increasingly shape political communication and public debate, questions regarding w
BACKGROUND: Many factors influence housing choices among older adults, but far from all have been identified. There is little systematic analysis that has included economic factors and virtually no knowledge about the interplay among perceived costs of moving, health status, and the mobility rate of older homeowners. It is currently unclear whether economic factors influence older adults' willingn
Rationale: Diffuse alveolar hemorrhage (DAH) is a life-threatening manifestation of antineutrophil cytoplasmic antibody-associated vasculitis (AAV). The PEXIVAS (Plasma Exchange and Glucocorticoids in Severe Antineutrophil Cytoplasmic Antibody-Associated Vasculitis) (NCT00987389) trial was the largest in AAV and the first to enroll participants with DAH requiring mechanical ventilation. Objectives
The authors of this policy brief are contributors to the research project Infrastructuring Libraries in Transformation (ILIT). ILIT’s objective is to examine public libraries’ role in this era beset by social challenges such as segregation, discrimination, austerity measures, and unemployment. ILIT began conducting research in three urban communities in 2022: Malmö, Sweden; Rotterdam, the Netherla
Members of the myocardin family bind to the transcription factor serum response factor (SRF) and act as coactivators controlling genes of relevance for myogenic differentiation and motile function. Binding of SRF to DNA is mediated by genetic elements called CArG boxes, found often but not exclusively in muscle and growth controlling genes. Studies aimed at defining the full spectrum of these CArG
Background: Explicit weight bias is known as negative attitudes and beliefs toward individuals due to their weight status and can be perpetuated through misconceptions about the causes of obesity. Individuals may also experience weight bias internalization (WBI) when they internalize negative weight-related attitudes and self-stigmatize. There is a paucity of research on the beliefs about the caus
Introduction: Despite being implicated in a wide spectrum of community- and healthcare-acquired infections, anaerobes have not yet been incorporated into systematic surveillance programs in Europe. Methods: We conducted a multicentre retrospective observational study analysing all anaerobic strains isolated from blood cultures in 44 European Hospital Centres over a 4-y period (2020–2023). Diagnost
Background: Metformin is one of the most used drugs worldwide. Given the increasing use of proteomics in trials, bioresources, and clinics, it is crucial to understand the influence of metformin on the levels of the circulating proteome. Methods: We analysed a combined longitudinal proteomics dataset from the IMPOCT, RAMP and S3WP-T2D clinical trials in 98 participants before and after metformin e
Atrial fibrillation (AF) is increasingly diagnosed early, close to its first occurrence due to: (i) increased public awareness with self-screening; (ii) health care initiatives including population screening and opportunistic case finding; and (iii) increased use and surveillance of implantable cardiac devices. At its onset, AF is often low burden, and cardiovascular co-morbidities may be absent o
