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Several genetic studies have demonstrated an association between mutations in glucocerebrosidase (GBA), originally implicated in Gaucher's disease, and an increased risk of Parkinson's disease (PD). We have investigated the possible involvement of genetic GBA variations in PD in the Swedish population. Three GBA variants, E326K, N370S, and L444P were screened in the largest Swedish Parkinson cohor
As the use of engineered nanomaterials increases, so does the risk of them spreading to natural ecosystems. Hitherto, knowledge regarding the toxic properties of nanoparticles (NP’s) and their potential interactions with natural bio-organic molecules adsorbed to them, and thereby forming surface coronas, is limited. However, we show here that the toxic effect of NPs of tungsten carbide cobalt (WC–
Changed utilization of black liquor in the pulp and paper industry has the potential to offer simplified carbon capture and, thus, negative net emissions from these large point sources. This can be achieved either by adapting existing recovery boilers to oxyfuel combustion or by replacing them with black liquor gasification technology. In this work, the chemistry during black liquor conversion was
For many years, prostate cancer early detection was a straightforward matter of recommending biopsy to all men with an elevated prostate-specific antigen (PSA). This is perhaps best evidenced by the European Randomized Trial of Screening for Prostate Cancer, where an automatic biopsy is specified in the protocol and close to 90% of men with a PSA ≥3.0 ng/mL were biopsied [1]. Starting around 2010,
Following Turkey’s 2018 currency crisis, the government introduced four key housing re-regulations which reduced mortgage interest rates, investment-based citizenship incentives, rent increase limitations, and monetary easing to stimulate economic recovery. This study examines how state-led financialization of housing disproportionately favours middle- and high-income groups while limiting access
Almost seven million Ukrainians have fled Ukraine since Russia’s large-scale invasion in February 2022. Seeking refuge in other European states, they were welcomed. However, recent analyses have emerged which point to an increasing discrimination against Ukrainian refugees who were displaced by Russia’s aggression, including in previously supportive nations like Poland. The shifting treatment and
The first measurements of proton emission accompanied by neutron emission in the electromagnetic dissociation (EMD) of Pb208 nuclei in the ALICE experiment at the Large Hadron Collider are presented. The EMD protons and neutrons emitted at very forward rapidities are detected by the proton and neutron zero degree calorimeters of the ALICE experiment. The emission cross sections of zero, one, two,
In this Letter, the first evidence of the (Formula presented) antihypernucleus is presented, along with the first measurement at the LHC of the production of (anti)hypernuclei with mass number (Formula presented), specifically (Formula presented) and (Formula presented). In addition, the antiparticle-to-particle ratios for both hypernuclei ((Formula presented) and (Formula presented)) are shown, w
A search for pair production of vector-like leptons coupling to first- and second-generation Standard Model leptons is presented. The search is based on a dataset of proton-proton collisions at s = 13 TeV recorded with the ATLAS detector during Run 2 of the Large Hadron Collider, corresponding to an integrated luminosity of 140 fb−1. Events are categorised depending on the flavour and multiplicity
The Lund jet plane (LJP) is measured for the first time in tt¯ events, using 140 fb-1 of s=13 TeV pp collision data collected with the ATLAS detector at the LHC. The LJP is a two-dimensional observable of the sub-structure of hadronic jets that acts as a proxy for the kinematics of parton showers and hadron formation. The observable is constructed from charged particles and is measured for R=1.0 a
In high-energy and astroparticle physics, event generators have an essential role, even in the simplest data analyses. Physical processes occurring in hadronic collisions are simulated within a Monte Carlo framework but a major challenge remains modelling of hadron dynamics at low momentum transfer, which includes the initial and final phases of every hadronic collision. Phenomenological models in
In this paper we review the physics opportunities at linear e+e− colliders with a special focus on high centre-of-mass energies and beam polarisation, take a fresh look at the various accelerator technologies available or under development and, for the first time, discuss how a facility first equipped with a technology that is mature today could be upgraded with technologies of tomorrow to reach m
This work reports femtoscopic correlations of p-−p(p‾-−p‾) and p−−d(p‾-−d‾) pairs measured in Pb–Pb collisions at center-of-mass energy per nucleon sNN = 5.02 TeV in the ALICE Collaboration. A fit to the measured proton-proton correlation functions allows one to extract the dependence of the nucleon femtoscopic radius of the particle-emitting source on the pair transverse mass (mT) and on the aver
A search for pair-production of vector-like leptons is presented, considering their decays into a third-generation Standard Model (SM) quark and a vector leptoquark (U1) as predicted by an ultraviolet-complete extension of the SM, referred to as the ‘4321’ model. Given the assumed decay of U1 into third-generation SM fermions, the final state can contain multiple τ-leptons and b-quarks. This searc
PHENIX presents a simultaneous measurement of the production of direct γ and π0 in d+Au collisions at sNN=200 GeV over a pT range of 7.5 to 18 GeV/c for different event samples selected by event activity, i.e., charged-particle multiplicity detected at forward rapidity. Direct-photon yields are used to empirically estimate the contribution of hard-scattering processes in the different event sample
