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All animals age. However, aging is a heterogeneous process, and individual organisms age differently. Moreover, within the same organism, cells or organs do not age at the same speed. For instance, neurodegeneration, a hallmark of aging, generally manifests later than other peripheral aging signs. The genetic determinants of aging are not completely understood. Gain-of-function (GoF) mutations in
Rapid urban growth in Africa is worsening air pollution in many cities, yet limited air-quality monitoring infrastructure hinders accurate assessment of residents’ exposure. In this study, we applied a land-use regression (LUR) model to estimate annual ambient fine particulate matter (PM2.5) concentrations and assess population exposure in Addis Ababa, Ethiopia. Estimated annual PM2.5 concentratio
State-of-the-art single and multi-junction perovskite solar cells (PSCs) employ SnOx grown using atomic layer deposition (ALD) atop perovskite/C60 structures. However, the detailed understanding of the growth dynamics and the chemical interaction between SnOx and the underlying perovskite/C60 structures are still underexplored. This work investigates the initial stages of SnOx growth on FAPbI3/C60
We present a comprehensive data-driven spectroscopic analysis of 357 415 red giant stars using Gaia DR3 Radial Velocity Spectrometer (RVS) spectra (8460–8700 Å; (Formula presented) ), aimed at deriving homogenous stellar parameters and elemental abundances (collectively referred to as stellar labels). We employ The Cannon, a generative model based on 2747 giants in common with GALactic Archaeology
Amphiphilic copolymers have emerged as powerful, detergent-free tools for solubilizing biological membranes, enabling the extraction and stabilization of membrane proteins within native-like lipid environments. We report a comprehensive, multi-technique elucidation of how polymer:lipid stoichiometry governs the formation, size, and stability of styrene-maleic acid lipid particles (SMALPs). Using c
Massive stars, the progenitors of neutron stars and black holes, play a crucial role in shaping the chemical and radiative properties of entire galaxies through their winds and explosive deaths. Stellar pulsations are a common phenomenon in massive stars and asteroseismology – the study of such pulsations – provides crucial constraints on the physics of massive star interiors. The excitation of he
Obsessive-compulsive disorder (OCD) is an impairing mental health condition that affects individuals across the lifespan. Some literature has evaluated mental health stigma in adults with OCD but limited attention has been given to youth, as well as those of Latino ancestry. The present study reported the extent of stigma experiences among Latin American youth with OCD, as well as examined sociode
BACKGROUND: – After acute ischemic stroke, it is uncertain whether the time of atrial fibrillation (AF) diagnosis (before or after stroke) or AF subtype (paroxysmal or permanent) modifies the treatment effect of early versus delayed direct oral anticoagulant (DOAC) initiation. METHODS: – OPTIMAS was a randomized, parallel-group, open-label trial with blinded outcome assessment. Participants with a
Genetic testing for cancer susceptibility underpins precision cancer prevention and care. Gaps in the healthcare providers’ genetic literacy and an ambiguous lexicon for variant description may hinder proper delivery and clinical application of consistently trustworthy test results. The Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) international consortium suppo
Background: No international consensus regarding optimal non-surgical or surgical treatment of metacarpal fractures exists. Surgical outcome using patient-reported outcome measurements (PROMs) from national registers with large surgically treated population have rarely been reported. We present demographics and patient-reported outcomes in relation to fixation methods for surgically treated metaca
Background To determine, in a general population, how much rates of stress reactions (SR), major depression (MD), alcohol-use disorder (AUD) and drug-use disorder (DUD) increase after the death of close relatives. Methods SR, MD, AUD, and DUD registrations were assessed from national Swedish registries. From the population followed from 2000 to 2018, those exposed to death of a close relative in 2
The purpose was to investigate whether the eosinophil biomarker EMR1, ectopically expressed in colon cancer tumor cells, could be used to identify patients at risk for relapse after curative surgery. EMR1 mRNA levels were determined in primary tumors (n = 66) and lymph nodes (LNs; n = 377) from 121 colon cancer patients. Controls were resection margins of colon cancer tumors and LNs from patients
An Introduction to Foreign Language Learning and Teaching provides an engaging, student-friendly, up-to-date guide to the field of foreign language learning and teaching. Aimed at students with no background in the area and taking a task-based approach, this thoroughly revised fourth edition: introduces the theoretical and practical aspects of both learning and teaching, and provides discussion an
The increasing demand for electric vehicle charging stations poses challenges for electric grid planning. This article proposes a framework for forecasting 24-hour peak-load profiles for new direct current fast-charging stations, defined here as planned or proposed stations with known static metadata, such as capacity, number of charging points, and location, but no historical load observations. T
This volume discusses documentary film, theatre, and literature from the 1960s to the 2020s in Belarus, Russia, Ukraine, and the Baltic states. It presents new developments in documentary aesthetics in the region but also expands on the political, medial, and aesthetic developments that shaped Soviet attitudes towards documentary arts and their legacy. Russia’s full-blown invasion of Ukraine has g
The incidence of early-onset colorectal cancer (EOCRC), diagnosed in individuals under 50 years, is rising across Europe, presenting a growing public health challenge distinct from later-onset disease. This review synthesizes the European landscape, revealing a heterogeneous epidemiological mosaic characterized by stark regional disparities in incidence, mortality-to-incidence ratios, and temporal
Magnetic resonance imaging (MRI) is central to the study and diagnosis of neurodegenerative diseases. Yet, no MRI biomarker is currently specific to a given neurodegenerative disease. This may result from the limited resolution of conventional MRI, which restricts detailed investigation of medial temporal lobe (MTL) subregions, a crucial hub for many neuropathologies. Moreover, in vivo MRI cannot
Climate activists are jailed for blocking roads. Students are denounced for setting up encampments. Antiracist demonstrators are publicly condemned as extremists. At a time marked by climate collapse, genocidal wars and widening inequality, those who interrupt business as usual are increasingly criminalized. The Responsibility to Disrupt examines controversies surrounding political protest and ask
Businesses are major drivers of biodiversity loss and face increasing pressure to assess and disclose risks to biodiversity from their activities. Yet it remains unclear which indicators businesses rely on to measure biodiversity, and whether these indicators represent biodiversity broadly enough to support robust decision-making. We reviewed which indicators Global Fortune 500 businesses in high-
Purpose: To evaluate the feasibility of hyperspectral imaging (HSI) for non-invasive characterization of pathological conditions in the human anterior segment and to explore its use alongside laser speckle contrast imaging (LSCI) for consecutive assessment of oxygenation and perfusion. Methods: 23 patients were examined with HSI and/or LSCI prior to evisceration or enucleation. HSI recorded diffus
