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Introduction - A small fraction of breast cancer is the result of germline mutations in the BRCA1 and BRCA2 cancer susceptibility genes. Mutation carriers frequently have a positive family history of breast and ovarian cancer, are often diagnosed at a young age, and may have a higher incidence of double or multiple primary breast tumours than breast cancer patients in general. Objectives - To esti

Activated coagulation factor V (FVa) functions as a cofactor to factor Xa (FXa) in the conversion of prothrombin (PT) to thrombin. This essential procoagulant reaction, despite being the subject of extensive investigation, is not fully understood structurally and functionally. To elucidate the structure of the FXa-FVa complex, we have performed protein:protein (Pr:Pr) docking simulation with the p

This thesis consists of four empirical essays, all dealing with return volatility of financial assets and/or time-varying risk premia. In the first essay, Changing Risk Premia: Evidence from a Small Open Economy, the relation between risk and return is investigated for Swedish stocks. Little is known about the differences in the risk-return relationship in large economies compared with smaller, l

We are currently investigating a device capable of generating continuous, coherent radiation down in the Angstrom region in sub-ps pulses in a relatively compact set-up. By placing a cascaded optical klystron (OK) in the return path of a 3 GeV Race Track Microtron operating in Energy Recovery mode Harmonic Generation can be performed in several stages in parallel. A four stage OK can generate Angs

I denna rapport studeras inverkan av frost i kombination med fukt på bärförmågan hos armerad balk förstärkt med kolfiberkomposit på vidhäftningen mellan betongen och kolfiberkompositen.

"Such in truth is our lot that while we are English to the Irish, we are Irish to the English. For the one island does not detest us more than the other." The sentiment expressed by the Anglo-Norman knight Maurice Fitzgerald in 1171 was one that many Anglo-Irish shared more than 700 years later. This study deals with an area of Anglo-Irish literature neglected by present-day researchers: novels wr

Popular Abstract in Swedish Att vara äldre, beroende av hjälp och leva med varaktig smärta. För äldre människor som är beroende av hjälp från omvärlden för att klara av sitt dagliga liv, utgör inte bara den nedsatta funktion ett problem. Många är drabbade även av andra problem, varav ett vanligt är ihållande och varaktig smärta. För vissa äldre med gravt nedsatt funktion kan språket ha drabbat's This thesis explores everyday living with persistent pain from the perspectives of functionally dependent older persons in pain and of staff. A combination of qualitative and quantitative methods was chosen. Data were collected using interviews and tools for assessing pain. The first data collection included 66 persons (65+) living in sheltered accommodation and their corresponding contact nurses.

The bacterial surfaces of enterococci are not uniform. This fact is confirmed by several studies and by our results when great differences between individual strains with regard to their cell surface hydrophobicity, binding of eight ECM (extracellular matrix) molecules immobilized on latex beads and four selected ECM molecules in microtiter plates were observed. The strains expressing high binding

Interfacial electron transfer is one of the key processes in the novel type of photovoltaic cells-dye sensitized solar cells (DSSC). By means of transient absorption spectroscopy we have studied the dynamics of the initial photo-induced processes in dye-sensitized nano-porous thin films of wide-band gap semiconductor microcrystallines, which represent the main photoactive part of DSSC. In the most

This paper considers detection of internal decay in standing trees of species Picea abies (L.) Karst. The novel approach is based on two-dimensional spatiotemporal modal analysis of a cross-section which is excited by the hand-made impact of a hammer. An array of accelerometers is distributed around the cross-section, and the resulting impact response is analysed. The temporal frequency for a spec

This thesis examines exclusion from the housing market, its justifications, and the resulting public images of the excluded. It is based upon a study of discourses within three different forms of social housing in Sweden; the poorhouse of the 19th century, the public housing sector of the 1980s and 1990s, and the housing currently supplied by the local social authorities. My emphasis is on the lat

Popular Abstract in Swedish Vad innebär det att vara en god medborgare? Frågan är lika enkel och tidlös som svaret är komplext och mångfacetterat. I grunden har det att göra med hur vi tänker politik. Frågan har i sin förlängning också djup moralisk innebörd och går tillbaka på våra normativa föreställningar om det goda samhället. Svaret vi ger varierar därför med olika värden och ideal; en god meWhat does it mean to be a good citizen? Starting with Aristotle’s ethics and philosophy of friendship formulated between the private and the public in politics' and with the timeless question of what makes a society possible as a backdrop, the author outlines a possible answer. A good citizen is a virtuous citizen, and a virtuous citizen is prudent, courageous, moderate and just. In addition, a go

This thesis examines the problem of smoke spread via ventilation ducts to adjacent room(s) in case of a compartment fire. The main goal is to examine the possibility of operating the fans during different fires in four types of buildings (compartments, hospitals, offices and hotels) and to estimate the risk of smoke spread in different conditions.

The global climate change caused by emissions of greenhouse gases from combustion processes has been recognized as a continuously growing problem and much research focuses on improving the environmental performance of gas turbines. The potential of improving gas turbine component efficiencies has become smaller each decade and therefore, thermodynamic cycles have become more interesting for power