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The polyamines are essential for cancer cell proliferation during tumorigenesis. Targeted inhibition of ornithine decarboxylase (ODC), i.e. a key enzyme of polyamine biosynthesis, by alpha-difluoromethylornithine (DFMO) has shown anti-neoplastic activity in various experimental models. This activity has mainly been attributed to the anti-proliferative effect of DFMO in cancer cells. Here, we provi

In contrast to ependymal cells located above the subventricular zone (SVZ) of the adult lateral ventricle wall (LVW), adult spinal cord (SC) ependymal cells possess certain neural stem cell characteristics. The molecular basis of this difference is unknown. In this study, antibodies against multiple cell surface markers were applied to isolate pure populations of SC and LVW ependymal cells, which

Polysaccharide-K (PSK, Krestin(®)) is a natural remedy and one of the most commonly used medicinal mushroom extracts. It has been used as oral adjuvant treatment in cancer therapy in Japan and other Asian countries for more than 40 years. PSK is thought to be an immune modulator, however, its antitumor actions remain undefined. The aim of the present study was to investigate underlying mechanisms

In order to mimic the real life situation, with often life-long exposure to the electromagnetic fields emitted by mobile phones, we have investigated in a rat model the effects of repeated exposures under a long period to Global System for Mobile Communication-900MHz (GSM-900) radiation. Out of a total of 56 rats, 32 were exposed once weekly in a 2-h period, for totally 55 weeks, at different aver

Current and next generation wireless networks including 3rd generation (3G) and beyond are expected to provide a wide range of multimedia services with different QoS constraints. Call admission control (CAC) and resource reservation (RR) for mobile communication are of the most important issues that guarantee system efficiency and QoS required for different services in a very scarce resource as th

We calculate the decay eta to3 pi at next-to-next-to-leading order or order p⁶ in Chiral Perturbation Theory. The corrections are somewhat larger than was indicated by dispersive estimates. We present numerical results for the Dalitz plot parameters, the ratio r of the neutral to charged decay and the total decay rate. In addition we derive an inequality between the slope parameters of

In the course of a few months in 1997, about 20 per cent of Stockholm Stock Exchange's primary-list firms transferred to the Exchange's secondary list due to a new tax policy. Drawing on a theory of social influence, we suggest that the transfer decisions depended both on the firms' social embeddedness with other firms in the population at risk and their economic predisposition to make such transf

An electrically small frequency-reconfigurable antenna with a very wide tuning band is proposed. Three varactor diodes are used to achieve the tunable capacitance. With a modifled feeding structure, the measured tuning range of the fabricated antenna reaches from 457.5 to 894.5 MHz, and the tuning band enhancement is also explained through an equivalent circuit analysis.

BACKGROUND: Deep venous thrombosis (DVT) is much less common in the upper than in the lower extremity. Furthermore, there is limited information on risk factors for and the prognosis of upper extremity (UE)DVT in the general population. AIMS: To estimate incidence, risk factors, and prognosis in UEDVT. MATERIAL AND METHODS: Among a total of 1203 patients with venous thromboembolism (VTE) diagnosed

PURPOSE To improve the poor prognosis of patients with primary disseminated multifocal Ewing sarcomas (PDMES) with a dose-intense treatment concept. PATIENTS AND METHODS From 1999 to 2005, 281 patients with PDMES were enrolled onto the Euro-EWING 99 R3 study. Median age was 16.2 years (range, 0.4 to 49 years). Recommended treatment consisted of six cycles of vincristine, ifosfamide, doxorubicin, a

The purpose of the study was to compare changes in oral health during intubation until 48 hours after extubation in neuroscience intensive care unit (ICU) patients enrolled in a standard or a comprehensive oral care protocol. The effects of manual toothbrushing (standard group, n = 31) were compared with those of tongue scraping, electric toothbrushing, and moisturizing (comprehensive group, n = 2

BACKGROUND: Former investigations have demonstrated that patch test preparations containing Disperse Blue (DB) 106 and DB 124 are impure. OBJECTIVE: To investigate the significance of impurities in preparations of disperse dyes with regard to contact allergy. MATERIALS/METHODS: 21 patients allergic to DB 106 and/or DB 124 were tested with dilution series of commercial and purified DB 106 and DB 12

Objective: To investigate the development of hand involvement and activities of daily life (ADL) in early systemic sclerosis (SSc), and to examine the usefulness of the Hand Mobility in Scleroderma (HAMIS) test in a longitudinal study. Methods: Forty-three patients with disease duration no longer than 3 years and at least 4 years of follow-up formed the study group. Based on skin involvement, 31 p

It is debated whether young athletes need to specialize early, or if it is more beneficial to follow the path of early diversification. The present study investigates the career paths and related motivational and volitional factors of Danish elite and near-elite team sport athletes. Seventy-six athletes matched by sport, age and sex participated in the study. Elite athletes started their career la