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Sterile liver inflammation and fibrosis are associated with many liver disorders of different etiologies. Both type 1 and type 2 inflammatory responses have been reported to contribute to liver pathology. However, the mechanisms controlling the balance between these responses are largely unknown. Natural killer T (NKT) cells can be activated to rapidly secrete cytokines and chemokines associated w
This paper describes a search for beyond the Standard Model decays of the Higgs boson into a pair of new spin-0 particles subsequently decaying into b-quark pairs, H→aa→(bb¯)(bb¯), using proton-proton collision data collected by the ATLAS detector at the Large Hadron Collider at center-of-mass energy s=13 TeV. This search focuses on the range 15 GeV≤ma≤30 GeV, where the decay products are collimat
Background: The Mendelian Society of Lund launched Hereditas in 1920. The purpose of this article is to give an overview of Hereditas’s hundred-year existence, focusing on the conditions for a learned society to publish a scientific journal, and the journal’s importance for the publication and dissemination of genetic research. The article focuses on the historical development of the journal and a
The cosmic origin of fluorine, the ninth element of the periodic table, is still under debate. The reason for this fact is the large difficulties in observing stellar diagnostic lines, which can be used for the determination of the fluorine abundance in stars. Here we discuss some recent work on the chemical evolution of fluorine in the Milky Way and discuss the main contributors to the cosmic bud
Background: Women account for 60% of all stroke deaths and are more often permanently disabled than men, despite their higher observed stroke incidence. Considering the clinical population affected by stroke, an obvious drawback is that many pre-clinical and clinical studies only investigate young males. To improve therapeutic translation from bench to bedside, we believe that it is advantageous t
Adeno Associated Virus (AAV)-mediated gene expression in the brain is widely applied in the preclinical setting to investigate the therapeutic potential of specific molecular targets, characterize various cellular functions, and model central nervous system (CNS) diseases. In therapeutic applications in the clinical setting, gene therapy offers several advantages over traditional pharmacological b
This study is the first to evaluate the setting up aid (SUA), in the Rural Development Programme. For Sweden, we investigate if the aid, firstly, speeds up the transition process to become manager of a farm and, secondly, affects income from farming and survival of the farm. The approach builds on a regression discontinuity design and explores an age 40-the eligibility requirement in the SUA. We f
One of the basic requirements of today's sophisticated world is the availability of electrical energy, and neglect of this matter may have irreparable damages such as an extensive blackout. The problems which were introduced about the traditional power grid, and also, the growing advances in smart technologies make the traditional power grid go towards smart power grid. Although widespread utilisa
Det finns många teorier och mycket tidigare forskning om autonomi och professionellt handlingsutrymme, men kunskapen om i vilken utsträckning rädslan för att utsättas för arbetsrelaterat våld begränsar denna autonomi och handlingsutrymme är begränsad. Denna artikel bygger på en enkätstudie (N =1,236) och jämför svenska socialarbetares, lärares och journalisters erfarenheter av arbetsrelaterat våldAlthough many theories have been developed and a great amount of research has been conducted on autonomy and professional discretion, knowledge on the extent to which fear of being subjected to workplace violence might restrict such autonomy and professional discretion being used is limited. This article draws on a survey study (N=1,236) and compares the experiences of workplace violence of Swedis
African countries such as Nigeria are anticipated to be more susceptible to the impacts of climate change due to reliance on rainfed agriculture. In this regard, the impacts of climate change on crop water requirements (CWR), yields and crop water productivity (CWP) of soybean in the Ogun-Ona River Basin, Nigeria, were evaluated for the baseline period (1986–2015) and future period (2021–2099) und
The decomposition of lignocellulose in nature, as well as when used as feedstock in industrial settings, takes place in a dynamic system of biotic and abiotic reactions. In the present study, the impact of abiotic reactions during the storage of pretreated lignocellulose on the efficiency of subsequent saccharification was investigated. Abiotic decarboxylation was higher in steam-pretreated wheat
The ability to define an off state in logic electronics is the key ingredient that is impossible to fulfill using a conventional pristine graphene layer, due to the absence of an electronic bandgap. For years, this property has been the missing element for incorporating graphene into next-generation field effect transistors. In this work, we grow high-quality armchair graphene nanoribbons on the s
Introduction: Sudden cardiac death (SCD) and early onset cardiomyopathy (CM) in the young will always lead to suspicion of an underlying genetic disorder. Incited by the rapid advances in genetic testing for disease we have revisited families, which previously tested “gene-negative” for familial predominantly pediatric CM, in hopes of finding a causative gene variant. Methods: 10 different familie
OBJECTIVE: To describe the organization, content and dosage of interdisciplinary pain rehabilitation, and the differences in degree of severity of problems of patients admitted to clinical units reporting to a Swedish national quality pain registry, grouped according to unit size and possible affiliation with a university hospital. METHODS: Reports from 31 out of 39 clinical units in Sweden, on in
Limitations in efficacy and/or tolerance of currently available urate-lowering therapies (ULTs), such as oral xanthine oxidase inhibitors, uricosurics, and intravenous uricase agents contribute to the development of refractory gout. Renal excretion is the major route of uric acid elimination, but the intestinal tract plays an increasingly recognized role in urate homeostasis, particularly in chron
Deterministic Lateral Displacement (DLD) is a label-free particle sorting method that separates by size continuously and with high resolution. By combining DLD with electric fields (eDLD), we show separation of a variety of nano and micro-sized particles primarily by their zeta potential. Zeta potential is an indicator of electrokinetic charge—the charge corresponding to the electric field at the
Has rising import competition contributed to the polarization of US politics? Analyzing multiple measures of political expression and results of congressional and presidential elections spanning the period 2000 through 2016, we find strong though not definitive evidence of an ideological realignment in trade- exposed local labor markets that commences prior to the divisive 2016 US presidential ele
In this paper, a new technique for reconstructing and identifying hadronically decaying τ+τ− pairs with a large Lorentz boost, referred to as the di-τ tagger, is developed and used for the first time in the ATLAS experiment at the Large Hadron Collider. A benchmark di-τ tagging selection is employed in the search for resonant Higgs boson pair production, where one Higgs boson decays into a boosted
Purpose: To assess the ability of clinical examination, blood biomarkers, electrophysiology, or neuroimaging assessed within 7 days from return of spontaneous circulation (ROSC) to predict poor neurological outcome, defined as death, vegetative state, or severe disability (CPC 3–5) at hospital discharge/1 month or later, in comatose adult survivors from cardiac arrest (CA). Methods: PubMed, EMBASE
Loss of forest naturalness challenges the maintenance of green infrastructure (GI) for biodiversity conservation and delivery of diverse ecosystem services. Using the Convention on Biological Diversity's Aichi target #11 with its quantitative and qualitative criteria as a normative model, we aim at supporting landscape planning through a pioneering assessment of the extent to which existing amount
