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Biglycan is widely distributed in the extracellular matrix and is a member of the small proteoglycan family characterized by a core protein with leucine-rich repeat motifs. We show in this paper for the first time that biglycan from human lung fibroblasts can be expressed as different isoforms. These isoforms can be separated from the predominant form of biglycan by hydrophobic interaction chromat

Popular Abstract in Swedish Molekylärgenetiska och funktionella studier av BCR/ABL1 fusionsgenen: Det finns tre sorters blodkroppar, röda, vita och trombocyter, som alla bildas från gemensamma stamceller i benmärgen. När stamcellerna delar sig bildas det antingen nya stamceller eller förstadier till blodkroppar som efter ytterligare delningar blir till mogna blodkroppar. Ibland uppkommer särskildThe BCR/ABL1 fusion gene is associated with chronic myeloid leukemia and a subgroup of acute lymphoblastic leukemia. The general aim of this thesis was to increase the understanding of BCR/ABL1-induced leukemogenesis by molecular and functional studies of this fusion gene. In Article I, an experimental U937 cell line model with inducible expression of BCR/ABL1 was established and characterized. Ex

Embedded declarative V2 clauses can appear in a number of different contexts in Norwegian and Swedish. What all these clauses have in common is that they have illocutionary force—they are asserted. I argue that a syntactic Force head is responsible for the illocutionary force as well as for the V2 order. Thus, the syntax and the semantics of embedded V2 clauses are closely tied together. The analy

OBJECTIVE--To investigate whether a lack of glutathione-S-transferase mu (GSTM1) activity was related to an increased risk for adverse outcome after asbestos exposure. METHODS--A study was made of 78 male former asbestos cement workers, with retrospective cohort data on exposure, radiographical findings, and lung function. Venous blood samples were obtained for the analysis of GSTM1 polymorphism b

Recent progress shows that neurons suitable for transplantation can be generated from stem cells in culture, and that the adult brain produces new neurons from its own stem cells in response to injury. These findings raise hope for the development of stem cell therapies in human neurodegenerative disorders. Before clinical trials are initiated, we need to know much more about how to control stem c

The problem of constructing generalized point interactions of the second derivative operator in L-2( R) leading to the same scattering data as for reflectionless potentials is considered. It is proved that this problem has a solution only if extensions in Pontryagin spaces are involved. The solution of the inverse scattering problem is not unique, this is illustrated by considering the scattering

In this paper we demonstrate a fast correlation attack on the recently proposed stream cipher LILI-128. The attack has complexity around 2(71) bit operations assuming a received sequence of length around 2(30) bits and a precomputation phase of complexity 2(79) table lookups. This complexity is significantly lower than 2(112), which was conjectured by the inventors of LILI-128 to be a lower bound

Based on a literature review and the SSG experience, the most important prognostic factors in high-grade osteosarcoma appear to be the presence of detectable metastases at diagnosis, tumour volume, old age, sex, histologic response, and possibly tumoral P-glycoprotein expression. However, for an adolescent patient with non-metastatic extremity disease, there is no consensus regarding prognostic fa

Gel electrolytes were prepared by swelling a self-assembling ABA triblock copolymer with different amounts of a solution of I M lithium bis(trifluoromethylsulfonyl)imide salt in gamma-butyrolactone. The triblock copolymer had endblocks of polyethylene (PE) and midblocks of poly(ethylene oxide-co-propylene oxide) (PEOPO), where the former blocks constituted 10 wt% of the copolymer. Thus, the electr

It was recently proposed to use variational functionals based on many-body perturbation theory for the calculation of the total energies of many-electron systems. The accuracy of such functionals depends on the degree of sophistication of the underlying perturbation expansions. An older such functional and a recently constructed functional, both at the level of the GW approximation (GWA), were tes

The article discusses the usefulness of the concept of North Eastern Europe. It was developed as a cognitive instrument in order for historical analysis to focus on social structures and processes rather than on states. Swedish historical consciousness is linked to the history of the seventeenth century, not least thanks to the historical novels by Peter Englund, Sweden of those times was a multin

gamma -Carboxylated proteins were detected in normal human pancreas by immunohistochemistry with a monoclonal antibody (M3B) specific for gamma -carboxyglutamyl residues, Staining appeared to be localized to the glucagon-secreting alpha -cells in the islets of Langerhans, Consistent with this, sections from a glucagonoma were stained much more intensely with the M3B antibody than those from an ins

We introduce a new notion of independence based on the Borel-Cantelli lemma. We study this characteristic in the context of i.i.d. stochastic processes and processes driven by equilibrium dynamics.

Background: To evaluate and describe the cone function in the normal and lesioned rabbit retina using the multifocal electroretinogram (mfERG). Methods: Twelve animals underwent a two-port vitrectomy with subsequent retinectomy in one eye. The area of removed retina was located in the nasal part of the visual streak, and measured approximately 1-2 disc diameters. Both eyes were investigated with m