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The genomes of lungfish, together with those of some urodele amphibians, are the largest of all vertebrate genomes. It has been assumed that the bulk of the DNA making up these large genomes has been derived from repeat elements, like the noncoding DNA of those genomes that have been sequenced (e.g., human). In an attempt to characterize repeat sequences in the lungfish genome, we have isolated, b

Energy expenditure, energy intake, body composition and selected biochemical analyses were studied in 14 males and 16 females with a mean age of 83 years (range 68-92) in geriatric long-stay wards. Energy expenditure was predicted from heart rate monitoring, and energy intake was assessed with a 4-day dietary record. Lean body mass (LBM), body fat (BF), and total body water (TBW) were estimated wi

The hemoprotein indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme in mammalian tryptophan metabolism. It has received considerable attention in recent years, particularly due to its role in the pathogenesis of many diseases. Here, we report attempts to improve soluble expression and purification of hexahistidyl-tagged recombinant human IDO from Escherichia coli (EC538, pREP4,

GeoBIM, the integration of 3D geoinformation (Geo) with building information models (BIM), is a subject of increasing attention in both domains. A well-known practical challenge for this integration is the mixed state of software support for open standards in each domain that would ease the integration. This is often known by practitioners but poorly documented. In order to solve this problem, we

Transforming growth factor-α (TGF-α) exerts several effects on target cells, such as neovascularization promotion and mitogenic signalling. Using immunoelectron microscopy, we show that monocytes and neutrophils, store TGF- α in cytoplasmic granules. In monocytes, TGF-α did not colocalize with components of peroxidase-positive granules or with albumin of secretory vesicles. Furthermore, no colocal

This chapter examines the evolution of public support for the euro and public trust in the European Central Bank (ECB) during the new currency’s first two decades. Using a unique set of opinion poll data that is not available for any other currency, we find that a majority of citizens in every member country of the euro area (EA) support the euro. The economic crisis in the EA following the Great

BACKGROUND: Accurate classification of breast cancer using gene expression profiles has contributed to a better understanding of the biological mechanisms behind the disease and has paved the way for better prognostication and treatment prediction.RESULTS: We found that miRNA profiles largely recapitulate intrinsic subtypes. In the case of HER2-enriched tumors a small set of miRNAs including the H

If we ever decide to start geoengineering another world, and maybe even terraform a world that is not presently habitable for humans, it is also highly probable that it will become less habitable for any indigenous life. Making sure, or at least trying to determine the probability that a potentially habitable world is in fact uninhabited will thus be an important step before we start any geo-engin