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The p53 gene product is a tumour suppressor protein, and alterations of the protein are common in human cancer. Previous studies have focused on nuclear accumulation of p53. To investigate if cytoplasmic accumulation of p53 strengthens the relationships to different pathobiological variables and distant recurrence-free survival in breast cancer, tumours from 164 stage II patients were examined wit
Objective. To compare the reproducibility of the standing extended view (SEV) (also known as the standing anteroposterior view) with the semiflexed, postero-anterior view [the 'metatarsophalangeal' (MTP)] view for assessing joint space width (JSW) and osteophytes in osteoarthritis of the knee when used in a busy routine X-ray department. Methods. Forty-seven patients (24 men) had both SEV and MTP
Adaptive data-dependent allocation designs are used in phase III clinical trials having two or more competing treatments with sequential entrance of patients, in order to allocate a larger number of patients to the better treatment. The odds ratio is a popular concept for biomedical practitioners; hence, odds-ratio-based adaptive designs could be very useful in practice. Rosenberger et al. (2001)
Telomerase reverse transcriptase (TERT) activity is up-regulated in several types of tumors including glioblastoma (GBM). In the present study, 128 primary glioblastoma patients were examined for single nucleotide polymorphisms of TERT in blood and in 92 cases for TERT promoter mutations in tumors. TERT promoter mutations were observed in 86% of the tumors and of these, C228T (-124 bp upstream sta
Clinical tools to guide treatment decisions in relapsed/refractory mantle cell lymphoma (R/R MCL) are limited. Moreover, the translational potential of circulating tumor DNA (ctDNA) remains largely unproven. We designed and applied panel-based duplex sequencing of ctDNA to study molecular determinants of response and outcome in 58 patients with R/R MCL treated with venetoclax, lenalidomide, and ri
Denna avhandling undersöker hur svenska män som betalar för sex ger mening åt sina handlingar och förhåller sig till ett moraliskt sammanhang präglat av kriminalisering, stigma och offentlig fördömelse. Med utgångspunkt i antropologiska perspektiv på moral, stigma och hemlighållande förstås männens berättelser som uttryck för moraliskt arbete: det pågående, situationsbundna arbete genom vilket indThis dissertation examines how Swedish men who pay for sex make sense of their actions and orient themselves within a moral landscape marked by criminalization, stigma, and public condemnation. Drawing on anthropological approaches to morality, stigma, and secrecy, the study conceptualizes the men’s accounts as forms of “moral work”: the ongoing, situated labor through which individuals seek to su
Hur kan svenska handelsföretag bli mer konkurrenskraftiga? Ja, inte är det genom att leka följa John i priskriget med de kinesiska plattformsföretagen. Det skriver Handelns ekonomiska råd – Cecilia Hermansson, Håkan Frisén, Ulf Johansson, Elin Nilsson – i en debattartikel.
Kinesiska marknadsplattformar som Temu och Shein kan utan ansvar saluföra såväl klimatmässigt ohållbara som oetiska och osäkra produkter
BACKGROUND: Digital technologies are increasingly central to supporting autonomy, health, and social participation in later life. However, disparities persist in the ability to keep up with technological developments, affecting individuals' opportunities to benefit from digital health and social innovations.OBJECTIVE: This study aimed to investigate factors associated with individuals' self-report
The ESS linac is under construction by the ESS partner institutes (socalled In-Kind Contributors - IKC) and will operate the most powerful proton beam ever for neutron spallation source. The linac delivers 5 MW via 2 GeV protons at a repetition rate of 14 Hz at the He-cooled solid tungsten target. The pulsed neutrons, result of the spallation, will reach the science instruments after having been m
BACKGROUND: Dupuytren disease (DD) is a benign fibroproliferative disorder affecting the hand. Although diabetes mellitus is a known risk factor, the underlying mechanisms behind this association remain unclear. This study aimed to examine the relationship between glycemic control and DD in type 1 (T1D) and type 2 diabetes (T2D), and to identify other metabolic risk factors influencing DD risk.MET
Network reconfiguration can significantly increase the hosting capacity (HC) for distributed generation (DG) in radially operated systems, thereby reducing the need for costly infrastructure upgrades. However, when the objective is DG maximization, jointly optimizing topology and power dispatch remains computationally challenging. Existing approaches often rely on relaxations or approximations, ye
Robotic surgery was developed to expand the patient population being offered a minimal invasive approach while retaining the associated advantages of minimal invasive surgery. Robotic surgery has been suggested to be particularly beneficial in surgery for malignant disease or in the presence of extensive intraabdominal adhesion, severe endometriosis, large uteri, high burden of comorbidity, or obe
Methods for percutaneous sampling such as core needle biopsy (CNB) and drill biopsy have, in recent years, emerged as important diagnostic substitutes for open biopsy of bone neoplasms. In addition, fine needle aspiration cytology (FNAC) has been used for the diagnosis of bone lesions under certain circumstances. As early as 1931, Coley and Ellis applied this sampling method to bone neoplasms. To
BackgroundResearch involving current and future generations of older adults in the design of smart home technology (SHT) is scarce. In this study, current and future generations of older adults, professionals, and researchers together sought to identify user needs and aspirations for and related to SHT. The aim was to co-produce prioritized ideas for SHT solutions to support engagement in everyday
New alternatives for treatment of overactive bladder (OAB) syndrome are continuously being explored. Despite ongoing nonclinical and clinical research, few new principles have evolved. We can expect future new additions to existing drug classes and different combinations of existing options. New antimuscarinics are in development, but we do not know if they offer any advantages to currently availa
