Clonal heterogeneity and evolution has major implications for disease progression and relapse in acute myeloid leukemia (AML). To model clonal dynamics in vivo, we serially transplanted 23 AML cases to immunodeficient mice and followed clonal composition for up to 15 months by whole-exome sequencing of 84 xenografts across two generations. We demonstrate vast changes in clonality that both progres

In comparison with other animal venoms, fish venoms remain relatively understudied. This is especially true for that of the lesser Echiichthys vipera and greater weever fish Trachinus draco which, apart from the isolation of their unique venom cytolysins, trachinine and dracotoxin, respectively, remain relatively uncharacterised. Envenomation reports mainly include mild symptoms consisting of noci

Next to the redesign of industrial products and processes, sustainable business model innovation is a strategic approach to integrate environmental and social concerns into the objectives and operations of organizations. One of the major challenges of this approach is that many promising business model ideas fail to reach the market, which is needed to achieve impact. In the literature, the issue

A semi-empirical power law-based theory has been developed to model the crystallization kinetics in precipitating systems for CO2 capture. A more reliable activity-based theory and simplified concentration-based crystallization kinetics have also been derived for a gas-liquid-solid system in which CO2 evolution might be unavoidable during the experiments performed to determine crystallization kine

The importance of indigenous knowledge in reducing risk from disasters andnatural calamities has been widely discussed in the social sciences by scholarsarguing for integrative frameworks and participatory processes. This type ofknowledge is vital for archipelagic developing countries, such as the Philippines, situated in a geographical area exposed to natural hazards. However, despite itspotentia

Under illumination, the photoluminescence of a mixed-halide perovskite such as MAPb(I1-xBrx)3 is known to undergo a significant intensity enhancement while spectrally shifting to lower energies. The evolution of low energy photoluminescence is attributed to the formation of iodide rich domains due to phase segregation. This process is detrimental for optoelectronic devices however the mechanism is

Myriad debates in electoral politics have drawn attention to the importance of and risks to genuine democracy brought about by factors such as campaign spending, incumbency, political party affiliation and political dynasties. However, only a few studies utilize integrative and multivariate approaches to understanding the contribution of these factors, and this is even rarer for studies on the Phi

The twisted elliptical tube heat exchangers with the novel coupling-vortex chessboard tube layout (TETHXs-CV) were simulated with the RNG k-ε model in software Fluent 15.0. The shell-side flow pattern at the tangential points between adjacent tubes in traditional TETHX is countercurrent while that in TETHX-CV is concurrent, which helps enhance heat transfer capability without any extra manufacturi

Dense time series of Landsat 8 and Sentinel-2 imagery are creating exciting new opportunities to monitor, map, and characterize temporal dynamics in land surface properties with unprecedented spatial detail and quality. By combining imagery from the Landsat 8 Operational Land Imager and the MultiSpectral Instrument on-board Sentinel-2A and -2B, the remote sensing community now has access to modera

Luminescence excitation spectra of BaBrI single crystals doped by divalent lanthanide ions are studied using synchrotron radiation excitations from the MAX IV 1.5 GeV storage ring. The energy of the edge and the formation of core cation exciton as well as the energy threshold of the multiplications of electronic excitations is found. It was clearly established the energy transfer from intrinsic lu

Design optimization of distributed energy systems has become an interest of a wider group of researchers due the capability of these systems to integrate non-dispatchable renewable energy technologies such as solar PV and wind. White box models, using linear and mixed integer linear programing techniques, are often used in their design. However, the increased complexity of energy flow (especially

The ALICE collaboration at the CERN LHC reports novel measurements of jet substructure in pp collisions at s=7 TeV and central Pb–Pb collisions at sNN=2.76 TeV. Jet substructure of track-based jets is explored via iterative declustering and grooming techniques. We present the measurement of the momentum sharing of two-prong substructure exposed via grooming, the zg, and its dependence on the openi

This article presents a gendered analysis exploring publication productivity in the Philippines using bibliometric data from the Web of Science. It investigates the temporal pattern of journal article publications for six disciplines, its gendered distribution, differences between disciplines, patterns of authorship and collaboration, and how much women authors contribute and participate in resear

One of the most significant roles of the EU in the world is that of being a norms exporter. The EU has concluded numerous agreements with countries in its neighbourhood with the aim of encouraging third countries to adopt EU acquis in exchange for access to the internal market. The most ambitious of these agreements are the three multilateral agreements establishing the European Economic Area, the

This article considers the possible effects of ‘Brexit’ on British nationals who would no longer be EU citizens. Any Member State withdrawing from the Union is unlikely to cut all ties to the Internal Market. It is almost inevitable that a departing State would need to set up a bilateral or multilateral arrangement for the purpose of continuing to participate in the Internal Market. The analysis c

The EU’s practice of exporting its acquis to third countries is increasingly coupled with the integration of third countries in the work of the Union’s agencies. The reasons for including third countries vary, as do the forms and intensity of the cooperation. The aim of this study is to assess the possibilities for non-EU member states, in particular those that adopt and implement EU acquis in the