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Despite rapid advances in mapping genetic drivers and gene expression changes in hematopoietic stem cells (HSCs), few studies exist at the protein level. We perform a deep, multi-omics characterization (epigenome, transcriptome, and proteome) of HSCs in a mouse model carrying a loss-of-function mutation in Tet2, a driver of increased self-renewal in blood cancers. Using state-of-the-art, multiplex

Cells grow by acquiring external resources and transforming them internally, forming new cells as they divide. Metabolic networks focus on the flow of such resources within the cell as they undergo series of biochemical reactions. How population growth emerges from these complex dynamical networks remains unclear. Modeling the emergence of population growth, a central ecological concept, is thus e

Global warming accelerates the breakdown of carbon stored in permafrost regions, releasing it into the atmosphere and amplifying climate change, particularly during winter when photosynthesis ceases. The Northern Hemisphere's permafrost is primarily concentrated in two key regions — the Arctic and the Tibetan Plateau — each with distinct environmental characteristics. However, previous studies oft

Particle induced oxidative stress is a probable pathway for many of the detrimental health-effects caused by particulate matter (PM). Recent studies on the exposure to oxidative potential (OP) in ambient fine and coarse PM suggest that anthropogenic particle pollutants, especially vehicular wear, anthropogenic primary and secondary organic aerosols (SOA) are more toxic on mass basis and more relev

Birds can show patterns of sexual size dimorphism as early as the nestling stage. This raises the question of how the faster growing sex might reconcile the energetic and nutritional needs of a faster growth rate with resource allocation to other important life functions, such as the development of innate immune function. Innate immunity represents the main line of defence against diseases, and wh

Proton exchange membrane fuel cell (PEMFC) electrodes comprise multiple functional components whose interplay critically influences both performance and long-term stability. In this article, the interaction between ionomer and catalyst materials was investigated using electrochemical quartz crystal microbalance with dissipation monitoring, enabling detection of potential-dependent changes in mass

Direct reprogramming of immune cells holds promise for immunotherapy but is constrained by limited knowledge of transcription factor (TF) networks. Here, we developed REPROcode, a combinatorial single-cell screening platform to identify TF combinations for immune cell reprogramming. We first validated REPROcode by inducing type-1 conventional dendritic cells (cDC1s) with multiplexed sets of 9, 22,

PURPOSE: The local immune infiltrate's influence on tumor progression may be closely linked to tumor-intrinsic factors. The study aimed to investigate whether integrating immunologic and tumor-intrinsic factors can identify patients from a low-risk cohort who may be candidates for radiotherapy (RT) de-escalation.EXPERIMENTAL DESIGN: The SweBCG91RT trial included 1,178 patients with stage I to IIA

Traffic-related air pollution has severe implications for our health and stringent emission legislation is being enforced to traffic emissions, for example in the EU, USA, and China. With stricter emission legislation (next is EURO 7) and a rapid growth of battery electrical vehicles (BEVs) the combustion-derived pollutants emitted from the tailpipe are decreasing. However, heavier vehicles have r

Skeletal muscle capillary density is correlated with physical performance and whole-body metabolic properties. Thus, we performed a genome-wide association study of skeletal muscle capillary-to-fiber ratio (C:F) (n = 603 males) and found that the rs115660502 G allele was associated (p < 5 × 10 -8) with increased C:F and reduced skeletal muscle expression of RAB3 GTPase-activating non-catalytic pr

I dagens samhälle blir det allt viktigare med säker kommunikation. Varje dag förlitar länder, företag och vanliga människor sig på säker kommunikation. Det kan vara personer som handlar på nätet, företag som förmedlar affärshemligheter eller länder som vill se till att valresultat inte läcker ut i förtid. Det är därför lätt att förstå behovet av kommunikation som är säker mot tjuvlyssnare. Det är The main aim of this thesis is to study the suitability of Semi Definite Programs (SDPs) as a method to solve problems in multipartite Quantum Key Distribution (QKD). Using SDPs to solve quantum information problems numerically is interesting because the solutions give strict upper (or lower) bounds which can be used to prove the security of protocols. In this thesis the security of QKD protocols

Unseen Sights: Magic, Modernity, and Childhood in Children’s Urban Fantasy explores and analyses the genre of children’s urban fantasy. Drawing upon a combination of fantasy, urban fantasy, and children’s literature scholarship, the thesis considers how children’s urban fantasy works – investigating both its forms and functions, and how it performs work in the world.The genre is analysed both sync