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Protein signatures of remodeled airways in transplanted lungs with Bronchiolitis Obliterans Syndrome obtained using laser capture microdissection

Bronchiolitis obliterans syndrome (BOS), a common form of chronic lung allograft dysfunction, is the major limitation to long-term survival after lung transplantation. The histological correlate is progressive, fibrotic occlusion of small airways, obliterative bronchiolitis lesions, ultimately leading to organ failure. The molecular composition of these lesions is unknown. By laser-capture microdi

Parental responsibility : a moving target

Beliefs about the moral status of children have changed significantly in recent decades in the Western world. At the same time, knowledge about likely consequences for children of individual, parental, and societal choices has grown, as has the array of choices that (prospective) parents may have at their disposal. The intersection between these beliefs, this new knowledge, and these new choices h

Weak association between socioeconomic Care Need Index and primary care visits per registered patient in three Swedish regions

OBJECTIVE: The objective was to examine the association between primary care consultations and a Care Need Index (CNI) used to compensate Swedish primary care practices for the extra workload associated with patients with low socioeconomic status.DESIGN: Observational study combining graphical analysis with linear regressions of cross-sectional administrative practice-level data.SETTING: Three Swe

An App Call a Day Keeps the Patient Away? Substitution of Online and In-Person Doctor Consultations Among Young Adults

The emergence of markets for online physician consultations -- direct-to-consumers telemedicine (DCT) -- is transforming healthcare services in many nations. The convenience of DCT lowers the cost of seeking care, thus potentially increasing demand. Yet, it is not known whether patients consuming online care turn to traditional providers as well. This is one of the first studies to causally assess

Method comparison of indirect assessments of understory leaf area index (LAIu) : A case study across the extended network of ICOS forest ecosystem sites in Europe

Leaf area index (LAI) is a key ecological indicator for describing the structure of canopies and for modelling energy exchange between atmosphere and biosphere. While LAI of the forest overstory can be accurately assessed over large spatial scales via remote sensing, LAI of the forest understory (LAIu) is still largely ignored in ecological studies and ecosystem modelling due to the fact that it i

Vem bygger vi för? : Om tillgänglighet och universell utformning i stadens rum

Vem bygger vi för? är den övergripande frågan i denna licentiatuppsats. Uppsatsensyftar till att belysa och problematisera hur människor inkluderas eller exkluderas iden byggda miljön, till följd av om, och hur mänsklig mångfald ges uttryck ochplats i plan och byggprocessen. Den bygger på två delstudier som behandlar hur detänkta användarna av den byggda miljön kategoriseras i planhandlingar ochstWho are we building for? This is the overarching question in this licentiate thesis.The thesis aims to shed light on and problematise how people are included orexcluded in the built environment due to if, and how human diversity is expressedand visible in the plan and construction process. It is based on two studies that dealwith how the intended users of the built environment are categorised in p

pH-Responsive Capsules with a Fibril Scaffold Shell Assembled from an Amyloidogenic Peptide

Peptides and proteins have evolved to self-assemble into supramolecular entities through a set of non-covalent interactions. Such structures and materials provide the functional basis of life. Crucially, biomolecular assembly processes can be highly sensitive to and modulated by environmental conditions, including temperature, light, ionic strength and pH, providing the inspiration for the develop

Dynamic alterations in the central glutamatergic status following food and glucose intake : in vivo multimodal assessments in humans and animal models

Fluctuations of neuronal activities in the brain may underlie relatively slow components of neurofunctional alterations, which can be modulated by food intake and related systemic metabolic statuses. Glutamatergic neurotransmission plays a major role in the regulation of excitatory tones in the central nervous system, although just how dietary elements contribute to the tuning of this system remai

Exopolysaccharides production by cultivating a bacterial isolate from the hypersaline environment of salar de uyuni (Bolivia) in pretreatment liquids of steam-exploded quinoa stalks and enzymatic hydrolysates of Curupaú sawdust

The halotolerant bacterial strain BU-4, isolated from a hypersaline environment, was identified as an exopolysaccharide (EPS) producer. Pretreatment liquids of steam-exploded quinoa stalks and enzymatic hydrolysates of Curupaú sawdust were evaluated as carbon sources for EPS production with the BU-4 strain, and the produced EPS was characterized using FTIR, TGA, and SEM. Cultivation was performed

Evaluating annoyance mitigation in the screening of train-induced noise and ground vibrations using a single-leaf traffic barrier

External sources such as traffic and construction work cause noise and vibration in nearby buildings, potentially annoying human residents. Today, almost every fifth European is harmfully affected by traffic noise and vibration. Wave barriers placed on or embedded within the soil between the source and the receiver can mitigate the transmission of ground vibration, and the airborne noise transmiss

Promise and performance of agricultural nutrient management policy : Lessons from the Baltic Sea

Following decades of international collaboration to restore the Baltic Sea, we provide an assessment of the domestic implementation of measures agreed to limit diffuse agricultural pollution and the patterns of policy instruments applied. Despite the Helsinki Convention being unusually specific in detailing what measures countries should introduce, we find many shortcomings. These are most pronoun

User acceptance of a personalised home lighting system based on wearable technology

Light/dark cycles play an essential role in people's performance, mood and daily rhythm. This study aimed to evaluate an early prototype of a personalised home lighting system including body-worn loggers. A convenience sample (N = 28) wore the devices for 23 h in the field and were given a demonstration of the lighting system components. Participants reported on questionnaires their acceptance of Light/dark cycles play an essential role in people's performance, mood and daily rhythm. This study aimed to evaluate an early prototype of a personalised home lighting system including body-worn loggers. A convenience sample (N = 28) wore the devices for 23 h in the field and were given a demonstration of the lighting system components. Participants reported on questionnaires their acceptance of

Dietary methyl-group donor intake and breast cancer risk in the european prospective investigation into cancer and nutrition (EPIC)

(1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and methionine, may influence breast cancer (BC) risk through their role in one-carbon metabolism; (2) Methods: We studied the relationship between dietary intakes of MGDs and BC risk, adopting data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort; (3) Results: 318,686 pre-and postmen