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In neuroblastoma (NB) patients, minimal residual disease (MRD) can be detected by real-time quantitative PCR (qPCR) using NB-specific target genes, such as PHOX2B and TH. However, it is unknown whether the mRNA levels of these targets vary either during treatment or at relapse. If marker genes are not stably expressed, estimation of MRD levels in bone marrow (BM) or peripheral blood will be hamper
Här kommer en ny artikel från utredningen över kritiska grupper av nordiska Caloplaca-arter, orangelavar. Denna gång handlar det om de isidiösa arterna inom C. herbidella-gruppen, där två svårskilda arter visade sig istället vara tre arter. Dessutom efterlyser författarna material av ett eventuellt fjärde taxon, vilket observerats i de norra delarna av Norden.
Background: The relationship between smoking and an increased incidence of cardiovascular diseases is well known. Whether smokeless tobacco (snuff) is related to myocardial infarction (MI) or stroke is still controversial. Aim of this study was to explore whether snuff users have an increased incidence of MI or stroke. Methods: A total of 16 754 women and 10 473 men (aged 45-73 years), without his
The interest in organizational play is growing, both in popular business discourse and organization studies. As the presumption that play is dysfunctional for organizations is increasingly discarded, the existing positions may be divided into two camps; one proposes 'serious play' as an engine for business and the other insists that work and play are largely indistinguishable in the postindustrial
Background: Subjects with non-O ABO blood group alleles have increased risk of pancreatic cancer. Glycosyltransferase activity is greater for the A(1) versus A(2) variant, whereas O01 and O02 variants are nonfunctioning. We hypothesized: 1) A(1) allele would confer greater risk than A(2) allele, 2) protective effect of the O allele would be equivalent for O01 and O02 variants, 3) secretor phenotyp
Recent debate and associated initiatives dealing with public sector innovation have mainly aimed at improving the effectiveness and efficiency of the delivery of public services and improved transparency and user friendliness. Beyond typical administrative reforms, innovation is expected to help address societal challenges such as the aging population, inclusion, health care, education, public saf
Collaboration between industry and academia supports improvement and innovation in industry and helps to ensure industrial relevance in academic research. This article presents an exploratory study of the factors for successful collaboration between industry and academia in software research.
Recent experiments on nanoscale conductors coupled to microwave cavities showed the prospect of transport investigations of electron-photon interplay in the deep quantum regime. Here we propose a pump-probe scheme to investigate the transient dynamics of individual electron-photon excitations in a double-quantum-dot-cavity system. Excitations pumped into the system decay via charge tunneling at th
In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin's lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combine
ALICE is an LHC experiment devoted to the study of strongly interacting matter in proton-proton, proton-nucleus and nucleus-nucleus collisions at ultra-relativistic energies. The ALICE VZERO system, made of two scintillator arrays at asymmetric positions, one on each side of the interaction point, plays a central role in ALICE. In addition to its core function as a trigger source, the VZERO system
Advancing the understanding of the aerosol-capture efficiencies of forest components such as leaves and needles, and of the mechanisms that underpin these efficiencies, is essential to the many related issues of forest turnover of nutrients and pollutants. For idealized collectors (such as artificial plates or cylinders) aerosol-mechanics offers a means for calculating capture efficiencies. For li
In traditional product development, several iterations are usually necessary to obtain a successful compromise between constraints emanating from engineering, manufacturing, and aesthetics. Moreover, this approach to product development is not well suited for true mass-customization, as the manufacturing company remains in control of all aspects of the shape of the product-to-be. In this article,
Neutron radiation produces high-energy gamma radiation through (n,gamma) reactions in matter. This can be used to detect neutron sources indirectly using gamma spectrometers. The sensitivity of a gamma spectrometer to neutrons can be amplified by surrounding it with polyvinyl chloride (PVC). The hydrogen in the PVC acts as a moderator and the chlorine emits prompt gammas when a neutron is captured
A striking feature of the discourses surrounding the negotiations of Economic Partnership Agreements between the EU and developing states is the starkly contrasting pictures given of the role and nature of the EU. The Union is either portrayed as an angel, an actor with altruistic objectives, concerned primarily with the economic and social development of the ACP countries, or as a demon, an actor
Our aim was to examine the effect of water stress on plant growth and development of two native plant species (Tetraclinis articulata and Crithmum maritimum) and on microbial community composition and activity in the rhizosphere soil, following the addition of an organic amendment, namely sugar beet residue (SBR), and/or the inoculation with an arbuscular mycorrhizal (AM) fungus, namely Glomus mos
A VCO is implemented in an RF 90 nm CMOS process and covers the frequency range 2.55-4.08 GHz. Drawing 19 mA from 1.2 V, the phase noise at 20 MHz frequency offset from a 3.7 GHz carrier is -156 dBc/Hz, meeting the phase noise requirement for GSM/EDGE and SAW-less WCDMA transmitter after frequency division by 2 or by 4. A second version of the VCO covers an additional 4.90-5.75 GHz range, at the e
Objective. To assess the clinical utility of repeat sacroiliac joint computed tomography (CT) in sacroiliitis by assessing the proportion of patients changing from normal to pathologic at CT and to which degree there is progression of established sacroiliitis at repeat CT. Methods. In a retrospective analysis of 334 patients (median age 34 years) with symptoms suggestive of inflammatory back pain,
