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PURPOSE: To explore modifications of the 2021 European Resuscitation Council/European Society of Intensive Care Medicine (ERC/ESICM) guideline algorithm for neuroprognostication after cardiac arrest to improve its prognostic accuracy.METHODS: Post-hoc analysis of four prospective multicentre studies (TTM, TTM2, KORHN and ProNeCA). We raised the Glasgow Coma Scale motor (GCS-M) inclusion threshold

This paper examines how, if artificial agents are capable of wellbeing, their wellbeing should be compared and aggregated alongside human wellbeing. Building on arguments from Goldstein and Kirk-Giannini, who suggest that some AI systems may possess wellbeing, I explore the moral implications of this possibility. Rather than reinventing debates in population ethics, this paper adapts and extends t

Multimedia environments consist of verbal and visual representations that, if appropriately processed, allow for the construction of an integrated mental model of the content. Whereas much is known on how students learn from verbal representations, there are fewer insights regarding the processing of visual information, alone or in conjunction with text. This chapter uses a semiotics approach to p

Perceiving and understanding human motion is a fundamental problem in computer vision, with diverse applications encompassing sports analytics, healthcare monitoring, entertainment, and intelligent interactive systems. Multi-camera systems, by capturing multiple viewpoints simultaneously, enable robust tracking and reconstruction of human poses in 3D, overcoming limitations of single-view approach

Studies investigating how the number of children in a family affects the parents or the children face problems because the variable of interestis endogenous in the model. The currently accepted solution to this problem is to use instrumental variables (IVs), for example, based on twin births. In this paper, I review and add to the critique of IVs based on twin births and show that that there are s

The local average treatment effect (LATE) estimator has enabled a wide range of empirical studies that usenatural experiments to estimate causal effects from observational data. However, this empirical literature has overlooked a crucial assumption regarding the definition of the treatment—thepart of the stable unit treatment value assumption referred to asthe consistency assumption in epidemiolog

Autonomous vehicles (AVs) have been the subject of extensive research in recent years and are expected to completely transform the operation of transport networks and revolutionize the automotive industry in the coming decades. Modeling detailed interactions among vehicles with varying levels of penetration rates is essential for evaluating the potential effects. One such investigation is being pe

The report presents an analysis of how sustainable business models can contribute to the transition to a more resource-efficient and circular economy. It highlights how economic, political, social and market factors influence the development and scaling of business models that reduce resource use, waste and climate impact. The results show that sustainable business models can be strengthened throu

INTRODUCTION: Epidemiological studies focusing on the association of exposure to perfluoroalkyl substances (PFAS) with cardiovascular disease (CVD) morbidity and mortality are limited, with inconsistent findings.OBJECTIVES: This register-based study aimed to investigate the associations between exposure to PFAS and the risk of CVD morbidity and mortality in a Swedish population exposed to PFAS, do

This study investigated the associations between solar and geomagnetic activity and circulating biomarkers of systemic inflammation and endothelial activation in the Normative Aging Study (NAS) cohort. Mixed effects models with moving day averages from day 0 to day 28 were used to study the associations between solar activity (sunspot number (SSN), interplanetary magnetic field (IMF)), geomagnetic

Estrogen influences T cell development and enhances infection resistance in females, but its immunological effects during gender-affirming hormone therapy (GAHT) remain poorly understood. Here, we characterize immune adaptations in male rhesus macaques (RMs) treated with 17β-estradiol (E2) or placebo over 7 months. E2 therapy suppressed endogenous testosterone production, induced female physical t

Immune function varies widely across humans. Biological sex is a key factor underlying human immune variability, with men presenting with more severe infections and increased cancer rates, while women exhibit higher vaccine responses and prevalence of autoimmunity. Intrinsic biological sex differences arise from varying contributions of chromosomal sex, and sex hormone sensing and downstream signa

OBJECTIVE: To externally validate the Paediatric Emergency Care Applied Research Network (PECARN) rule for identifying febrile infants aged <60 days at low risk of serious bacterial infections (SBIs) and assess the utility of the rule with C reactive protein (CRP) instead of procalcitonin (PCT).METHODS: Secondary analysis of data from the Management and Outcomes of Fever in Children in Europe (MOF

Although prior falls are a well-established predictor of future fracture, there is currently limited evidence regarding the specific value of falls history in fracture risk assessment relative to that of other clinical risk factors and bone mineral density (BMD) measurement. We therefore investigated, across the three Osteoporotic Fractures in Men (MrOS) Study cohorts, whether past falls predicted

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference a