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The growth and resorption of bone are governed by interaction between several cells such as bone-forming osteoblasts, osteocytes, lining cells and bone-resorbing osteoclasts. The cells considered in this study reside in the periosteum. Furthermore, they are believed to be activated by certain substances to initiate bone growth. This study focuses on the role that stress driven diffusion plays in t
Aim of the study: The primary purpose of this study is to investigate if pretreatment plasma levels of vascular endothelial growth factor (VEGF) are predictive of the effect of celecoxib on survival in advanced non-small cell lung cancer (NSCLC) treated with palliative chemotherapy. A secondary objective is to describe the course of plasma VEGF levels during and after treatment with cytotoxic chem
Background The well-being of patients with Parkinson's disease may be improved by pharmaceutical care in community pharmacies. Objective To investigate the effects of standardised pharmaceutical care on health outcomes and quality of drug treatment in patients with Parkinson's disease. Setting Community pharmacies in Germany. Method An open-label, multicentre, longitudinal, parallel-group study wa
The article engages in the critical debates over the utopian aspects of the Western heritage that took place in the wake of the Second World War. A striking feature of these debates is how thinkers from the entire political spectra – from Georg Lukács to Isaiah Berlin and Eric Voegelin – made very similar analyses, although they draw quite different conclusions. Hence all of them blamed German Rom
Ferrochelatase, the terminal enzyme of the heme biosynthetic pathway, catalyzes the insertion of ferrous iron into protoporphyrin IX to give heme. Resonance Raman spectroscopy has been instrumental in defining the distortion (mode and extent) of the porphyrin substrate, which is a critical step in the catalytic mechanism of ferrochelatase. Saddling is the predominant porphyrin out-of-plane deforma
The effect of temperature on the recovery of bacterial growth after rewetting dry soil was measured in a soil that responded with bacterial growth increasing immediately upon rewetting in a linear fashion (type (i) response sensu Meisner et al. (Soil Biol Biochem 66: 188-192, 2013)). The soil was air-dried for 4 days and then rewetted at different temperatures. Bacterial growth over time was then
An analytical model for estimating the link loss for the on-body wave propagation around the torso is presented. The model is based on the attenuation of the creeping waves over an elliptical approximation of the human torso and includes the influence of the arms. The importance of including the arms’ effect for a proper estimation of the link loss is discussed. The model is validated by the full-
This article is a follow-up of Alvesson and Karreman (2011a), which was in itself a follow-up of Alvesson and Karreman (2000), and a response to a critique of the former by Hardy and Grant (2012). The critique is addressed directly and the logic behind it investigated critically. The article also addresses wider concerns regarding the politics of research and publishing and the conditions of criti
We have investigated the effect of an external magnetic field on the angular distribution and the linear polarization of the 2p(2)2p(5)3s(3)P(2)(o) -> 2s(2)2p(6) S-1(0) emission line in Ne- like ions. Since an electric dipole decay channel is opened by the magnetic field and competes with the inherent magnetic quadrupole transition, these properties strongly depend on the magnetic field strength,
We aimed at assessing changes in AV nodal properties during administration of the beta blockers metoprolol and carvedilol, and the calcium channel blockers diltiazem and verapamil from electrocardiographic data.
We calculated the vector, axial-vector, scalar and pseudo-scalar two-point functions up to two-loop level in the low-energy effective field theory for three different QCD-like theories. In addition we also calculated the pseudo-scalar decay constant G M. The QCD-like theories we used are those with fermions in a complex, real or pseudoreal representation with in general n flavours. These case corr
The Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) clinical trial, including 1,873 patients found an increased risk for cancer with lipid-lowering therapy with ezetimibe/simvastatin 10/40 mg/day, relative to placebo. In a registry-based follow-up study over 21 months from the conclusion of the SEAS trial, new incident cancer and total mortality were investigated in the SEAS study cohort from
Patients with systemic lupus erythematosus (SLE) have a decreased ability to clear cell remnants and multiple deficiencies in the ability to degrade cellular chromatin have been linked to the disease. Since the discovery of neutrophil extracellular traps (NETs), a renewed interest has been sparked in this field of research with multiple studies reporting a decreased ability of patients with SLE to
This study aims to theorize more concretely the micro-foundations of reform strategies with attention to the role of would-be reform winners in motivating strategy choice. The theory incorporates insights about multidimensional preferences into Weaver’s framework and builds on a growing literature on the framing of welfare state change in order to hypothesize that governments may face a vote-seeki
Chlorides, nitrates and sulfates play an important role in the salt-decay of porous materials in buildings and monuments. Electrochemical desalination is a technology able to remove salts from such porous materials in order to stop or prevent the decay. In this paper, experimental and numerical results for ED treatments of red bricks contaminated with NaCl, NaNO3, and Na2SO4 are presented and comp
An increased understanding of cellular uptake mechanisms of macromolecules remains an important challenge in cell biology with implications for viral infection and macromolecular drug delivery. Here, we report a strategy based on antibody-conjugated magnetic nanoparticles for the isolation of endocytic vesicles induced by heparan sulfate proteoglycans (HSPGs), key cell-surface receptors of macromo
Abstract in UndeterminedThe present paper describes how the control of a radiator system connected to a district heating (DH) network via a heat exchanger can be optimized to provide the lowest possible DH return temperature. This can be achieved for each operating point by employing an optimal combination of radiator circuit supply temperature and circulation flow rate. The control algorithm grad
