The thesis is focused on an attempt to delay photoreceptor cell death in the rd1 mouse using Lens Epithelium Derived Growth Factor (LEDGF), Glutathione S-Transferase mu (GST-?? and Glutathione S-Transferase alpha (GST-?? in an organ culture paradigm as well as the role of metalloproteases (MMPs) and their tissue inhibitors in photoreceptor degeneration (TIMPs). The rd1 mouse model displays a reti

OBJECTIVES: To describe the drug use in epilepsy and Parkinson's patients living in nursing homes and to evaluate the impact of multi-speciality team intervention on health-related quality of life, activities of daily living (ADL) and confusion state. METHODS: Nursing home residents with epilepsy or Parkinson's disease in the county of Skåne in Sweden were identified. From 119 nursing homes, 262 p

During the late winter of 1983, 16 newborns with vague symptoms of failure to thrive, reluctance to feed and a slight rise in body temperature, were found to have meningitis caused by Coxsackievirus A-14. The cerebrospinal fluid showed pleocytosis with polymorphonuclear cells in excess but was otherwise normal. The clinical course was uneventful in all infants, but two of them demonstrated clinica

The aim of this study was to analyse the relationship between different biometric parameters and sapflow and growth, respectively, in order to assess their potential for use in scaling. The effect of thinning on these relationships was also investigated. The studied stand consisted of Scots pine (ca. 60%), Norway spruce (ca. 35%) and downy birch (ca. 5%). Sapflow was measured by the tissue heat-ba

"Krismedvetande" är ett nytt ord i svenska språket. Trots att den svenska ekonomin genomgått både hög- och lågkonjunkturer under de senaste tjugo åren, har behovet av krismedvetande varit i det närmaste permanent. Har Sverige blivit ett "krissamhälle", ett samhälle som bär stora likheter med vad som i tysk debatt benämns "risikogesellschaft", risksamhälle?

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To characterize the gene activity that may be required for neuronal survival and regeneration, we used the Affymetrix GeneChip Mu74A to screen 12000 genes and expressed sequence tag (EST) mRNA from L4 and L5 mouse dorsal root ganglia (DRG) 12 h and 24 h after sciatic nerve transection. At 12 h, we found 17 upregulated transcripts, and at 24 h, 49 that met our criteria of a significant 2-fold incre

Two assertions made by the Eastern meditation traditions were investigated: (a) breath regulation is a prerequisite for attaining altered states of consciousness, (b) meditation leads to changes in cognitive processes and in personality. A deconditioning process was conceptualized involving the temporal lobes and the amygdala. Analyses of (a) the effects of carbon dioxide (CO2) inhalation and (b)

Satellite data from the SeaWiFS sensor has been used to determine chlorophyll-a contents in the North Aegean Sea using SEADAS 3.3 software. The data is used to extract knowledge on water movements/flow phenomena using chlorophyll as a "tracer" but will also indicate water quality. More than 100 SeaWiFS scenes from 1998 up to 2001 have been analyzed in terms of hydrodynamic phenomena, mainly the tr

Exacerbations are the key drivers in the costs of chronic obstructive pulmonary disease (COPD). The objective was to examine the costs of COPD exacerbations in relation to differing degrees of severity of exacerbations and of COPD. We identified 202 subjects with COPD, defined according to the BTS and ERS criteria. Exacerbations were divided into mild (self-managed), mild/moderate (telephone conta

Förarbete till förarbete till kapitel två i biografin Alfred Hitchcock: A Life in Darkness and Light (London: Wiley 2003:24-46).

We have studied the kinetics of the solubilization of oil through a temperature jump into a droplet microemulsion phase in the system water-pentaethylene oxide dodecyl ether-decane at 25 C. The initial state is formed by subjecting the equilibrium system at 25 C to a temperature quench to 22, 20, and 14 C, respectively. At this lower temperature, which at equilibrium corresponds to a two-phase sys

This thesis summarizes work using hard X-ray radiation on nanosecond and picosecond timescales. The focus is on the experimental part including detailed descriptions of setups for laser pumped - X-ray probe experiments. X-ray diffraction is sensitive to structural properties on the length scale of chemical bonds. The greatest success of X-ray diffraction lies in the determination of crystal struct

Objectives: To investigate the effect of prolonged neutralisation of tumour necrosis factor alpha (TNFalpha) on the radiological course in rheumatoid arthritis (RA). To assess whether the radiological course can be predicted by clinical variables or biological markers of cartilage and synovium turnover and of endothelial activation. Patients and methods: Forty seven patients with active RA enrolle

The decays of the high angular momentum, high spin F-4(0) states of the electron configuration 3s3p3d in aluminium-like ions (with three electrons outside a closed shell) have been identified in delayed spectra of foil excited Ti, Fe and Ni ion beams. The line identifications were aided by HXR, MCHF, and MCDF calculations and are corroborated by lifetime measurements which demonstrate the differen

A state-dependent variable-gain control system is implemented to follow the characteristics of a laboratory-scale up-flow anaerobic fixed-bed reactor dynamically. The transition from one state to another is determined on an hourly basis, depending on difference between the setpoint of the reactor pH and its true value. Considerable improvement of the process stability - reduction of oscillation in

This thesis is about fixedness, or the process whereby orthographic words group together and congeal into fixed expressions that might subsequently reduce and become single words. The discussion focuses on three levels: realization, conceptualization, and discourse. At the level of realization, substitution tests have traditionally been employed to ascertain degrees of fixedness in expressions. T