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Computational fluid dynamics (CFD) modeling may aid in planning of invasive interventions in Fontan patients. Clinical application of current CFD techniques is however limited by complexity and long computation times. Therefore, we validated a "lean" CFD method to magnetic resonance imaging (MRI) and an "established" CFD method, ultimately aiming to reduce complexity to enable predictive CFD durin

ObjectiveTo report trends and characteristics of post-biopsy infections, with regard to etiology and resistance patterns, in a large unique cohort from a single-centre using the same antibiotic prophylactic regimens during a 15-year period.MethodsThis is an observational cross sectional cohort study, including all patients who underwent transrectal prostate biopsy (TR PBx) guided by ultrasound for

An energy transition is unfolding in Canada and across the world. During this transition, countries are facing increasing demands for their energy systems to address economic, social, and environmental considerations, including providing affordable and reliable energy, reducing inequality, and producing fewer environmental impacts. First, we identify key themes from the academic literature related

We measured 135 cross sections of residual nuclei produced in fragmentation reactions of 12C, 14N, and 13−16,20,22O projectiles impinging on a carbon target at kinetic energies of near 400A MeV, most of them for the first time, with the R 3 B/LAND setup at the GSI facility in Darmstadt (Germany). The use of this state-of-the-art experimental setup in combination with the inverse kinematics techniq

This article analyses the role that ‘ordre public’ and morality exceptions can play in the granting of patents on inventions in the field of human germline editing and the consequences of this policy option. In order to provide the context for such an analysis, the article will, first, provide an overview of the current patent landscape for relevant genome editing technologies, drawing attention t

Crystallography is an invaluable tool in materials science, solid state physics and protein science. Understanding crystallography requires grasping the powerful but abstract concept of reciprocal space. Here a simple but insightful experiment using a laser pointer and Au microdisc arrays to explore and illustrate Bragg diffraction and reciprocal space is demonstrated. The Au microdisc arrays were

The Cenozoic Himalaya-Tibet orogen is generally regarded as the archetypal continental collision zone and is often used as an analogue for interpreting ancient orogenic events. However, given the wide diversity observed in present-day collisional mountain belts, the extent to which such inferences can be made remains debated. In this Review, we compare the metamorphic and magmatic record of the Hi

Selenium has been suggested to be protective regarding breast cancer risk but no overall effect has been established. Genetics may modify the effect. This study compares the effect of selenium exposure on breast cancer risk between women with different alleles in single-nucleotide polymorphisms (SNPs). The Malmö Cancer and Diet Study, a cohort including 17,035 women and >25 years of follow-up on b

En analys av alla större imperiers undergång från forntiden till idag, med målet att urskilja gemensamma mönster i utvecklingen.

Policymakers and scientists are paying increasing attention to how social norms can promote pro-environmental behaviour and sustainable energy use. We contribute to this field by experimenting with and assessing the impacts of social norms on low-carbon mobility options. Taking Sweden as a case study, we develop two complementary randomised controlled experiments to: 1) analyse the role of social

We report the development of a platform of dual targeting Fab (DutaFab) molecules, which comprise two spatially separated and independent binding sites within the human antibody CDR loops: the so-called H-side paratope encompassing HCDR1, HCDR3 and LCDR2, and the L-side paratope encompassing LCDR1, LCDR3 and HCDR2. Both paratopes can be independently selected and combined into the desired bispecifWe report the development of a platform of dual targeting Fab (DutaFab) molecules, which comprise two spatially separated and independent binding sites within the human antibody CDR loops: the so-called H-side paratope encompassing HCDR1, HCDR3 and LCDR2, and the L-side paratope encompassing LCDR1, LCDR3 and HCDR2. Both paratopes can be independently selected and combined into the desired bispecif

När skottskogsbruket/stubbskottsängsbruket upphörde i början av 1800-talet försvann även landskapet som humlesugan, Betonica officinalis L., var anpassad till. Från att ha varit allmän på sydvästra Lolland och i västra Mellanskåne blev den mycket sällsynt inom dessa kärnområden i humlesugans tidigare utbred- ning i Skandinavien. Ändå lyckades den överleva på sju lokaler. För att bevara dessa krävsWhen coppice forestry and the use of wooded meadows ceased in the early 19th century, the landscape to which Betony, Betonica officinalis L., was adapted also disappeared. From being common in southwestern Lolland and in western Mid­Skåne, it became very rare in these core areas of Betony’s earlier distribution in Scandi­ navia. However, the species has managed to survive at seven localities and t

OBJECTIVE: FLASH irradiation reportedly produces less normal tissue toxicity, while maintaining tumour response. To investigate oxygen's role in the 'FLASH effect', we assessed DNA damage levels following irradiation at different oxygen tensions, doses and dose rates.METHODS: Samples of whole blood were irradiated (20 Gy) at various oxygen tensions (0.25-21%) with 6 MeV electrons at dose rates of