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Unilateral intrastriatal and intra-medial forebrain bundle injections of 6-OHDA impair the performance in a lateralised choice reaction time task. However, the extent and pattern of deficits after nigral 6-OHDA injections is less well studied, as well as the impact of training regime or the modification of various task parameters. The nigral 6-OHDA lesion resulted in impaired response accuracy and
We present a study that suggests greening in the circumpolar high-latitude regions amplifies surface warming in the growing season (May-September) under enhanced greenhouse conditions. The investigation used a series of climate simulations with the Community Atmospheric Model version 3-which incorporates a coupled, dynamic global vegetation model-with and without vegetation feedback, under both pr
The results from bending tests on 107 laminated, green-glued, beams manufactured from Norway spruce side boards are presented. The beams were made by face gluing 21-25 mm thick boards using a commercial one-component moisture curing polyurethane adhesive. In addition to the bending test results, results from shape stability measurements after climatic cycling and bond line strength and durabili
General-purpose Monte Carlo event generators have become important tools in particle physics, allowing the simulation of exclusive hadronic final states. In this article we examine the PYTHIA 8 generator, in particular focusing on its parton-shower algorithms. Some relevant new additions to the code are introduced, that should allow for a better description of data. We also implement and compare w
In order to fully understand pathogen induced natural variation in fitness in wild animal populations it is important to identify and study the degree of non-synonymous alleles in genes that code for components of the immune system. This study investigates the degree of natural genetic variation at 6 innate immune genes belonging to the -defensin family within a single population of birds, the gre
Using long-term (1954-2004) observations of four selected species in South Korea: goldenbell (Forsythia koreana), azalea (Rhododendron mucronulatum), cherry (Prunus yedoensis), and peach (Prunus persica), the impact of urban warming on spring flowering was investigated. Trends of early spring temperatures and first-flowering dates (FFDs) of the four plants were cross-compared among nine differentl
Human synovial joints display a characteristic anatomic distribution of arthritis e.g. rheumatoid arthritis primarily affects the metacarpophalangeal and proximal finger joints, but rarely the distal finger joints, while osteoarthritis occur in the distal and proximal finger joints. Pelvospondylitis has a selective localization to the spine and sacroiliac joints. Is this tropism due to differences
Nuclides that are considered to be isotopes of element Z = 115 were produced in the reaction 48Ca + 243Am at the GSI Helmholtzzentrum für Schwerionenforschung Darmstadt. The detector setup TASISpec was used. It was mounted behind the gas-filled separator TASCA. Thirty correlated α-decay chains were found, and the energies of the particles were determined with high precision. Two important spectros
China is currently promoting indigenous technology development thought support of Chinese firms and, arguably, by restricting operations of foreign multinational firms. This policy seems to overlook the impact of foreign firms on technology development in local firms. For instance, technology might leak out to local firms though spillovers. Moreover, competition from foreign firms might force loca
The role of cabergoline in Cushing's disease (CD) remains controversial. The experience is limited to case reports and few open studies that report the effects determined after ≥1 month of treatment. In prolactinomas and dopamine-responsive GH-secreting tumours, effects of cabergoline are seen within days or weeks. Here, we searched for short-term effects of cabergoline in CD.
The delta C-13 record from an early Sheinwoodian limestone unit in the Prague Basin suggests its deposition during the time of the early Sheinwoodian carbon isotope excursion (ESCIE). The geochemical data set represents the first evidence for the ESCIE in the Prague Basin which was located in high latitudes on the northwestern peri-Gondwana shelf during early Silurian times.
Many elderly men with high-risk nonmetastatic prostate cancer (HRnMPCa) do not receive radical treatment, despite the high mortality associated with conservative management.
The transfer of α-synuclein (α-syn) between cells has been proposed to be the primary mechanism of disease spreading in Parkinson's disease. Several cellular models exist that monitor the uptake of recombinant α-syn from the culture medium. Here we established a more physiologically relevant model system in which α-syn is produced and transferred between mammalian neurons. We generated cell lines
Esters of the pentacyclic sesquiterpene velutinal have been isolated from Lactarius species, and converted to the free alcohol by base-catalyzed transesterfication in EtOH/EtO-.
The Short Pulse Facility (SPF) of the MAX IV Laboratory in Lund, Sweden features the production of ultrashort, incoherent x-ray pulses. It is driven by a 3-GeV linac and comprises two 5-metre undulator modules. While the SPF is designed for spontaneous radiation, we explore alternative operation modes in which the SPF functions as a simple free-electron laser (FEL). In this article, we characteriz
We further the studies of the model-based optimization of tapered free-electron lasers presented in a recent publication [Phys. Rev. ST Accel. Beams 18, 040702 (2015)]. Departing from the ideal case, wherein the taper profile is a smooth and continuous function, we consider the more realistic case, with individual undulator segments separated by break sections. Using the simulation code GENESIS, w
In this article, we propose an arbitrage-free modelling framework for the joint dynamics of forward variance along with the underlying index, which can be seen as a combination of the two approaches proposed by Bergomi. The difference between our modelling framework and the Bergomi (2008. Smile dynamics III. Risk, October, 90–96) models is mainly the ability to compute the prices of VIX futures an
Haemophilia is a congenital disorder with bleeding episodes as its primary symptom. These episodes can result in negative outcomes including joint damage, loss of active days due to hospitalization and reduced quality of life. Effective treatment, however, can improve the outcome. Registries have been used as a valuable source of information regarding the monitoring of treatment and outcome. The t
In this article, we propose an analytical approximation for the pricing of European options for some log-normal stochastic volatility models. This approximation is a second-order Taylor series expansion of the Fourier transform with respect to the “volatility of volatility.” We give, using these formulas, a new method of variance reduction for the Monte Carlo simulation of the trajectories of the
In this article, we study the price monotonicity in the parameters of the Heston model for a contract with a convex pay-off function; in particular we consider European put options. We show that the price is increasing in the constant term in the drift of the variance process and decreasing in the coefficient of the linear term in the drift of variance process. We also show that the price is incre
