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Importance: The use of prostate-specific antigen (PSA) screening for prostate cancer is controversial because of the risk of overdiagnosis and overtreatment of indolent cancers. Optimal screening strategies are highly sought. Objective: To estimate the long-term risk of any prostate cancer and clinically significant prostate cancer based on baseline PSA levels among men aged 55 to 60 years. Design
Objectives: The current survival of patients with distal cholangiocarcinoma (dCCA) is poor. There is a need to develop new prognostic and predictive biomarkers to improve the survival of patients. Fibroblast activation protein (FAP) expression has been associated with survival in several solid malignancies. The goal of this study was to evaluate the expression pattern and prognostic significance o
The disease COVID-19 has developed into a worldwide pandemic. Hyperinflammation and high levels of several cytokines, for example, IL-6, are observed in severe COVID-19 cases. However, little is known about the cellular origin of these cytokines. Here, we investigated whether circulating leukocytes from patients with COVID-19 had spontaneous cytokine production. Patients with hyperinflammatory COV
Purpose: To investigate case mix in relation to capsule complication, possible associations between case mix and operation volume, and change in case mix over time. Design: Register-based study. Participants: Swedish patients who underwent cataract surgery between 2007 and 2016. Methods: Demographics and data on ocular comorbidity, intraoperative difficulties, and capsule complications were regist
Phlorotannins are bioactive polyphenols in brown macroalgae that make these algae interesting as healthy food. Specific phlorotannins are, however, seldom identified, and extracts from different species are often only analysed for total phenolic content (TPC). In this study, our focus was to identify phlorotannin molecules from Saccharina latissima and Ascophyllum nodosum (a species rich in these
Non-technical summary Agriculture provides many benefits to people, such as producing food and creating jobs in rural areas, but it can also have negative impacts on the environment. We analysed existing monitoring indicators for the European Union’s Common Agricultural Policy (CAP) to evaluate whether the CAP is effectively achieving multiple social and environmental goals. We found that the curr
Happiness or subjective well-being is often measured by assessing individuals’ judgments of life satisfaction and experience of positive and negative affect (Diener, Psychological Bulletin, 95, 542-575, 1984). In addition, recent research suggests that individuals’ sense of harmony in life is also an important component of subjective well-being (Kjell et al., Social Indicators Research, 126, 893-9
Camouflage may promote fitness of given phenotypes in different environments. The tawny owl (Strix aluco) is a color polymorphic species with a gray and brown morph resident in the Western Palearctic. A strong selection pressure against the brown morph during snowy and cold winters has been documented earlier, but the selection mechanisms remain unresolved. Here, we hypothesize that selection favo
Peoples’ tendencies to be manipulative, opportunistic, selfish, callous, amoral, and self-centered (i.e., an outlook of separateness; Cloninger, Feeling good: The science of well-being, Oxford University Press, 2004; Southern Medical Journal, 100, 740-743, 2007; Mens Sana Monographs, 11, 16-24, 2013) are reflected in individual differences in three dark traits: Machiavellianism, narcissism, and ps
Pressurised meltwater has a major impact on ice dynamics, as well as on sedimentary and deformational processes occurring below/in front of glaciers and ice sheets, but its role in glaciotectonic processes is yet to be fully understood. This study explores micro- and macroscale structures developed within décollements in two thrust-block moraines of Late Weichselian age in Melasveit, western Icela
Objectives: To compare the performance of ultrasound measurements and subjective ultrasound assessment (SA) in detecting deep myometrial invasion (MI) and cervical stromal invasion (CSI) in women with endometrial cancer, overall and according to whether they had low- or high-grade disease separately, and to validate published measurement cut-offs and prediction models to identify MI, CSI and high-
Marginal zone lymphoma of the central nervous system (CNS MZL) is rare. The clinical features, treatment, and prognosis are not well characterized. We performed a multicenter retrospective study of CNS MZL. Twenty-six patients were identified: half with primary and half with secondary CNS involvement. The median age was 59 years (range 26-78), 62% female and 79% with ECOG performance status ≤ 1. T
This article aims to explore if social exclusion can constitute a pathway to radicalization, and if individual level of sensitivity of rejection moderates the effect of social exclusion. Humans innately seek belonging and meaning, and strive for re-establishing a sense of value and belongingness if faced with social exclusion. One way to achieve this is by adherence to a new and inviting group. In
In this communication, a novel planar structure-shared diverse two-port ultrawideband (UWB) antenna with high isolation and common ground is proposed based on a new slot-loaded method. A tapered slot with an end-fire radiation pattern is etched in the top middle section of a coplanar waveguide (CPW)-fed printed monopole antenna to reduce its effects on the monopole mode. The two-port UWB antenna f
The HUSH complex represses retroviruses, transposons and genes to maintain the integrity of vertebrate genomes. HUSH regulates deposition of the epigenetic mark H3K9me3, but how its three core subunits — TASOR, MPP8 and Periphilin — contribute to assembly and targeting of the complex remains unknown. Here, we define the biochemical basis of HUSH assembly and find that its modular architecture rese
The aggregation of α-synuclein is a central event in Parkinsons’s disease and related synucleinopathies. Since pharmacologically targeting this process, however, has not yet resulted in approved disease-modifying treatments, there is an unmet need of developing novel methods of drug discovery. In this context, the use of chemical kinetics has recently enabled accurate quantifications of the micros
Given the tremendous phenomenological success of the Standard Model (SM) framework, it becomes increasingly important to understand to what extent its specific structure dynamically emerges from unification principles. In this study, we present a novel anomaly-free supersymmetric (SUSY) Grand Unification model based upon gauge trinification [SU(3)]3 symmetry and a local SU (2) F× U (1) F family sy
Mechanical loading affects tendon healing and recovery. However, our understanding about how physical loading affects recovery of viscoelastic functions, collagen production and tissue organisation is limited. The objective of this study was to investigate how different magnitudes of loading affects biomechanical and collagen properties of healing Achilles tendons over time. Achilles tendon from f
This paper employs Swedish data on households' stock holdings to investigate how consumption responds to changes in stock market returns. We instrument the actual capital gains and dividend payments with past portfolio weights. Unrealized capital gains lead to a marginal propensity to consume of 23% for the bottom 50% of the wealth distribution and about 3% for the top 30% of the wealth distributi
Background: Conduct disorder (CD), a serious behavioral and emotional disorder in childhood and adolescence, characterized by disruptive behavior and breaking societal rules. Studies have explored the overlap of CD with neurodevelopmental problems (NDP). The somatic health of children with NDP has been investigated; however, the prevalence of these problems in children with CD has not been suffici
