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Glacial and climate history of the Antarctic Peninsula since the Last Glacial Maximum

During the Last Glacial Maximum (LGM), ice thickened considerably and expanded toward the outer continental shelf around the Antarctic Peninsula. Deglaciation occurred between >14 ka BP and ca. 6 ka BP, when interglacial climate was established in the region. Deglaciation of some local sites was as recent as 4-3 ka BP. After a climate optimum, peaking ca. 4-3 ka BP, a distinct climate cooling occu

Connectivity and performance of science-based firms

This paper addresses whether or not there is a relationship between a young science-based firm's patterns of connections and the associated resource flows, and its performance. Hypotheses derived from the literature are tested in relation to three performance indicators: inventiveness, innovativeness and employment. Analyzing a set of firms in Sweden, Ohio and Massachusetts, working with biocompat

A longitudinal study of material planning applications in manufacturing companies

Purpose-The paper seeks to describe the state-of-the-art, reasons for selecting various material planning methods, and modes of applying methods for initiating inventory replenishment of purchased items. It also identifies trends from 1993 to 2005. Design/methodology/approach-Empirical survey data are collected from Swedish manufacturing companies in 1993, 1999 and 2005. The MRP, re-order point, f

Leukotriene D-4 induces stress-fibre formation in intestinal epithelial cells via activation of RhoA and PKC delta

The intestinal epithelial barrier, which is regulated by the actin cytoskeleton, exhibits permeability changes during inflammation. Here we show that activation of the CysLT(1) receptor by the inflammatory mediator leukotriene D-4 (LTD4) causes a rapid increase in stress-fibre formation in intestinal epithelial cells. This effect was mimicked by cytotoxic necrotising factor-1 (CNF-1)-induced activ

Maternal smoking and congenital malformations

Since the first report by Simpson (1957) of the association between premature birth and maternal smoking, the research on the consequences of maternal smoking during pregnancy on perinatal outcome has been intense. Even if some of the findings have been contradictory, it is now evident that maternal smoking is associated with pre-term birth and low birth weight, low birth weight for gestational ag

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation

Inflammation is a key pathology in asthma. In the central airways local inflammation leads to irreversible remodeling and airway dysfunction. Complex inflammatory changes also occur in the nose, sinuses, and small airways. In particular, rhinitis and asthma are linked by a common pathogenic process with common inflammatory cells, mediators, and cytokines. Cross-communication between the airways an

Seasonal variation in home-range size, and habitat area requirement of the lesser spotted woodpecker (Dendrocopos minor) in southern Sweden

Seasonal variation in home-range size and habitat area requirement of lesser spotted woodpeckers (Dendrocopos minor) were studied by radio-tracking in southern Sweden for 6 years. Home-range size did not vary between age-groups or sexes, but varied with season and decreased successively from 742 ha in winter (n = 10), 355 ha in early spring (n = 15), 103 ha in late spring (n = 22) to 43 ha during

Cytogenetic features of multiple myeloma: impact of gender, age, disease phase, culture time, and cytokine stimulation

Relatively little is known about the cytogenetic features of multiple myeloma (MM) when compared to other hematologic malignancies. The reasons for this are most likely manifold, and include a low mitotic index of the malignant cells and the presence of cytogenetically cryptic abnormalities as well as of complex karyotypes with poor chromosome morphology. In the present study, we have investigated

Functional and biochemical characterization of epithelial bactericidal/permeability-increasing protein

Epithelial cells of many mucosal organs have adapted to coexist with microbes and microbial products. In general, most studies suggest that epithelial cells benefit from interactions with commensal microorganisms present at the lumenal surface. However, potentially injurious molecules found in this microenvironment also have the capacity to elicit local inflammatory responses and even systemic dis

Measurements of the frequency-dependent impedance of a thin wire with ground return

Measurements of the frequency-dependent impedance of a thin wire with ground return is performed. We argue that the results from a downscaled experimental setup are useful and relevant for power-line applications. The experimental result is compared with two categories of line models. The first category is a model that uses fixed line parameters and the second category consists of models where the

von Willebrand disease update: diagnostic and treatment dilemmas

Although von Willebrand disease (VWD) is now well-described, many facets of diagnosis and management continue to be debated. The diagnosis of type 1 disease can be difficult but recent genetic analyses help to distinguish many factors which can influence von Willebrand factor (VWF) levels and bleeding phenotype. Type 2 disease (functional abnormalities) includes a particularly interesting group of

Characterization of water-soluble hemicelluloses from spruce and aspen employing SEC/MALDI mass spectroscopy

Partly depolymerized hemicelluloses isolated from wood chips of spruce and aspen employing microwave treatment were resolved using size-exclusion chromatography (SEC) into oligo- and polysaccharide fractions containing components with a narrow range of sizes, as determined by MALDI mass spectroscopy. The degree of substitution with acetyl moieties (DS) was also calculated on the basis of the MALDI