Human epidermal growth factor receptor 2 (HER2) status in breast cancer is routinely determined through immunohistochemistry (IHC) and/or in situ hybridisation (ISH) performed on whole tissue sections (WS). The purpose was to evaluate whether a gene protein assay (GPA) combining IHC with ISH, performed on breast cancer tissue microarray (TMA), is suitable for large-scale retrospective HER2 status

Given underdetermined measurements of a positive semi-definite (PSD) matrix X of known low rank K, we present a new algorithm to estimate X based on recent advances in non-convex optimization schemes. We apply this in particular to the phase retrieval problem for Fourier data, which can be formulated as a rank 1 PSD matrix recovery problem. Moreover, we provide a theory for how oversampling affect

This book presents new socio-legal perspectives and insights on the social life of corruption and anti-corruption in authoritarian regimes.This book takes up the case of Uzbekistan—an authoritarian regime in Central Asia and one of the most corrupt countries in the world according to Transparency International’s Corruption Perceptions Index—and examines the corruption that developed in a tightly c

Algorithms for Massive MIMO uplink detection and downlink precoding typically rely on a centralized approach, by which baseband data from all antenna modules are routed to a central node in order to be processed. In the case of Massive MIMO, where hundreds or thousands of antennas are expected in the base-station, said routing becomes a bottleneck since interconnection throughput is limited. This

Until relatively recently, a diagnosis of probable Alzheimer's disease (AD) and other neurodegenerative disorders was principally based on clinical presentation, with post-mortem examination remaining a gold standard for disease confirmation. This is in sharp contrast to other areas of medicine, where fluid biomarkers, such as troponin levels in myocardial infarction, form an integral part of the

Objectives To assess the association between neonatal BCG vaccination and mortality between 28 days and 3 years of age among tuberculosis (TB)-exposed and TB-unexposed children. Design Prospective cohort study. Setting Bandim Health Project runs an urban Health and Demographic Surveillance site in Guinea-Bissau with registration of mortality, vaccination status and TB cases. Participants Children

The objective of this paper is to build a model of how tacit knowing is externalised and becomes reflected external knowledge. Knowledge Management (Nonaka, 1991, 1994; Nonaka, Toyama, & Konno, 2000) is an important field in Business Administration. Based on the model provided by Nonaka and his colleagues (Nonaka, 1994; Nonaka & Takeuchi, 1995; Nonaka et al., 2000) researchers and practiti

Background: We report the outcomes of a prospective consecutive series of 267 total ankle replacements (TARs) using a new mobile bearing Rebalance® prosthesis. Methods: Between April 2011 and December 2018, 267 consecutive Rebalance® prostheses were implanted in 255 patients at 3 different centers. Estimated survival curves with 95% confidence intervals were produced with the Kaplan–Meier method.

Studies have suggested that fluoxetine might improve neurological recovery after stroke, but the results remain inconclusive. The EFFECTS (Efficacy oF Fluoxetine - a randomisEd Controlled Trial in Stroke) reached its recruitment target of 1500 patients in June 2019. The purpose of this article is to present all amendments to the protocol and describe how we formed the EFFECTS trial collaboration i

The current study is aimed at highlighting the impact of enterally or parenterally applied immunoglobulins (Igs) on polyunsaturated fatty acid (PUFA) absorption in newborn pigs. Piglets were chosen as the appropriate model since they are born agammaglobulinemic and any effects of Ig addition can thus be easily monitored. Twenty-one, new born piglets were used in the study. Plasma levels of PUFAs,

A simple Pickering emulsion route has been developed for the assembly of temperature-responsive poly(N-isopropylacrylamide) (PNIPAM) microgel particles into colloidal molecules comprising a small number of discrete microgel interaction sites on a central oil emulsion droplet. Here, the surface activity of the microgels serves to drive their assembly through adsorption to growing polydimethylsiloxa

Organic lead halide perovskite (OLHP) nanocrystals (NCs) have paved the way to advanced optoelectronic devices through their extraordinary electrical and optical properties. However, understanding of the light-induced complex dynamic phenomena in OLHP NCs remains a subject of debate. Here we used wide field microscopy and time-resolved spectroscopy to correlate the local changes in photophysics an

This is a revised and extended version of my contribution to the Vega Symposium on Resurgent Nationalisms and Populist Politics in the Neoliberal Age, held at the Swedish Academy of Sciences, Stockholm, in April 2018. It is part of a Special Issue of Geografiska Annaler, Series B which also includes articles by Gillian Hart, Kanishka Goonewardena, and Manu Goswami. The article investigates how und

The current study examined the role of visually perceived material properties in motor planning, where we analyzed the temporal and spatial components of motor movements during a seated reaching task. We recorded hand movements of 14 participants in three dimensions while they lifted and transported paper cups that differed in weight and glossiness. Kinematic- and spatial analysis revealed speed-a

In this chapter we examine how we can deepen our understanding and expertise as higher education teachers through ongoing personal and professional development, building on the notion in Chapter Three that ‘Our teaching is always in the process of developing’. The chapter begins with an overview of what it means to develop our ‘expertise’ in higher education teaching and puts this in relation to t