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Transposable elements make up over 50% of the human genome and serve beneficial transcriptional regulatory roles but can also exert deleterious effects when aberrantly expressed. Four de novo missense mutations in the master regulator of transposable elements – corepressor TRIM28 – were identified in four patients with intellectual disability suggesting that dysfunctional transposable element regu
Ocean acidification, warmer temperatures, and the expansion of hypoxic zones in coastal areas are direct consequences of the increase in anthropogenic activities. However, so far, the combined effects of these stressors on calcium carbonate-secreting marine microorganisms - foraminifera are complex and poorly understood. This study reports the foraminiferal survival behavior, and geochemical tr
Spectroscopy serves as a vital tool in both scientific research and industrial applications. In spectral analysis, baseline correction is important in order to be able to efficiently extract essential features. Several algorithms for baseline correction have been developed, including Asls (Asymmetric Least Squares algorithm), arPLS (Asymmetrically Reweighted Penalized Least Squares algorithm), air
Background The estrogen receptor alpha (ERa), encoded by ESR1, is overexpressed in 75 – 80 % of breast cancers. Treatments targeting ERa are challenged by development of resistance due to loss of ERa expression. It is crucial to increase understanding of regulatory mechanisms of ERa expression and identify alterations in these mechanisms. Modifications of miRNA target sites in ESR1 3’ UTR or meth
Bakgrund: Behandling av huvud-halscancer kan medföra komplikationer, däribland laryngofaryngela ödem. Laryngofaryngeala ödem kan leda till påtagliga konsekvenser för patienter. Laryngofaryngeala ödem kan resultera i försämrad funktion tal, röst och sväljning samt försämrad livskvalitet. Ödem är även associerat med kronisk inflammation vilket kan leda till fibros. Det är därför viktigt att i tidigt
Glioblastoma (GBM) is the most aggressive type of primary brain tumours in adults and accounts for 49.1% of the cases. Most of the cases are recorded in elderly patients, but GBM affects people of all age groups. Till date no cure has been found. Previous data has suggested that pericytes might influence tumour invasion by interacting with tumour cells by the secretion of or interaction with extra
Technological advancements have significantly transformed the healthcare landscape, particularly with the emergence of technological augmentation in healthcare settings. This research aims to investigate the impact of technological augmentation on nurse skills. The study seeks to analyze how integrating the Electronic Health Records affects the skill sets of nurses. The research methodology involv
Understanding how organisms respond to their environment is essential in an increasingly fast changing world. For many organisms, phenotypic plasticity is the first response to environmental change. I investigated 1) if there are consistent differences in plastic response in three environmental gradients (Nitrogen/Phosphorus ratio, salinity and temperature) and 2) quantified the variation in react
This study investigates the potential for energetic self-reliance in an integrated biore- finery, the Earth Power Lodge (EPL), which aims to convert waste into valuable by- products through bio- and thermochemical conversion processes. The primary questions addressed include assessing the necessity of external propane to sustain the pyrolysis process and the net energy output of the ThermoChemical
This thesis examines the strategies adopted and the challenges professionals face while providing cognitively disabled youths with sexual education. The study was conducted via qualitative interviews of professionals working with cognitively disabled youth, ranging between teachers, youth club workers, and sexual health educators. The thesis’ chief findings showed that professionals adopted the st
Coming from a predominantly Catholic country, Lithuanian immigrants in Scandinavia find themselves in a contrasting Protestant context of the host societies. This ethnographic study of diasporic Lithuanian communities and their transnational Catholic practices aims to understand what motivates immigrant Lithuanians to join the church in Sweden or Norway and whether this foreign environment influen
The aim of this study was to investigate how hospital counselors in specialized palliative care reason about their discretion and their professional role in the multi-professional team, in order to deepen the understanding of their professional role as well as the psychosocial work that is carried out within the medical context. The methodology was based on a qualitative approach using seven semi-
An ERP implementation is an intricate process that requires comprehensive planning, designing and execution. The implementation encompasses virtually all aspects of an organization’s business processes, as well as the organizational culture. A successful ERP implementation are affected by numerous modules that needs to be thoroughly considered for an optimal solution. User involvement is one of th
This thesis investigates the characteristics of the current water management system of Hojancha, a small canton in the Guanacaste region of Costa Rica. The canton of Hojancha in Costa Rica is the subject of this research because there, an effective community-led water management initiative has been put in place. Still, future water stress and conflicts are likely to further develop. Understanding
The aim of this study is to investigate how newspaper articles from the Swedish newspaper Expressen have presented cannabis in the years 1992 and 2022. The objective was to compare the coverage between these years. After applying selection criteria and random selection, 70 articles were chosen for analysis. The method on which this work is based is qualitative text analysis. The content from the a
The objective of this study was to investigate what are the most common types of digital violence that social workers come across and how they assess their seriousness. Our research questions were: 1/ What types of digital violence exist and how common are they? 2/ How do social workers assess the severity of the types of violence? 3/ Does the ranking and seriousness assessment differ between
This paper seeks to provide insights into the effects of carbon border tariffs and to offer guidance for policymakers. The focus is directed towards the steel sector - a major contributor to carbon dioxide emissions, where production practices vary significantly among countries, leading to differences in pollution levels. Our primary focus is on the proposed carbon border tariff by the United Stat
