We report a new design of an acoustophoretic trapping device with greatly increased capacity and throughput, compared to current commercial systems. Acoustic trapping enables nanoparticle and exosome enrichment without the need for ultracentrifugation. The commercial acoustic trapping technology, AcouTrap (AcouSort AB), typically operates at flow rates < 50 μl/min which limits processing of larger

This article presents a political and legal analysis of the emergency brake in criminal law in Articles 82(3) and 83(3) TFEU. It suggests that the emergency brake offers a powerful discretionary prerogative for Member States seeking to protect the integrity of their criminal justice systems. This strong legal shield for Member States in the form of a ‘quasi-veto’ is contrasted with a tendency to d

We demonstrate proof of principle of an efficient and simple method combining sample preparation and stretching of DNA in a single device that can be used as basis for an integrated portable system for optical DNA mapping. An important bottleneck for DNA mapping, as well as for other methods, is the isolation of long DNA molecules from a background of contaminants such as shorter DNA fragments, dy

To evaluate the effect of antibiotic drugs, it is important that the cells that are killed can be sorted from the cells that are resistant to the antibiotics. Here we report a simple label-free method for the continuous separation of viable/non-viable cells using Electrokinetic Deterministic Lateral Displacement. In general, this opens up for continuous sorting of a population of cells that is hom

The precise separation of nanoscale particles has proven challenging due to diffusion and the need to use nanoscale devices. We show the separation of particles in the 100 nm size range in Deterministic Lateral Displacement (DLD) devices with feature sizes in the 10 µm size range. We achieve this using Dielectrophoretic (DEP) forces, generated between the metal coated posts that act as active elec

Freely grazing horses are at risk of infection by parasites such as Parascaris equorum (roundworm), Strongylus spp. (large bloodworms), Cyathostomes (small bloodworms), and Anoplochephala perfoliata (tapeworms). Mixed infections are common and diagnosis is based on demonstrations of eggs in feces followed by identification of larvae after fecal culture. Drug resistance is a growing problem, not le

A variety of pathogenic bacteria can infect humans and the increase in bacteria resistant to common antibiotics is a large threat to human health worldwide. This work presents a method, based on optical DNA mapping (ODM) in nanofluidic channels, that can detect the type of bacterial present in a sample by matching the obtained maps of large DNA molecules to a database of fully assembled bacterial

We present a method to rapidly fabricate a large number of thermoplastic microfluidic systems where horizontal microchannels are separated by a porous membrane for modelling biological barriers. We optimize and combine solvent bonding, milling and laser cutting to fabricate in excess of 100 devices in two days. The optimized protocol relies on a commercial solvent blend, retention grooves for solv

The bioeconomy is currently being globally promoted as a sustainability avenue involving several societal actors. While the bioeconomy is broadly about the substitution of fossil resources with bio-based ones, three main (competing or complementary) bioeconomy visions are emerging in scientific literature: resource, biotechnology, and agroecology. The implementation of one or more of these visions

Research SummaryGrowth often requires start‐ups to recruit new skills not present in the founding team. We analyze if the relationship between integrating new skills and growth depends on timing. Should new skills be recruited as early as possible, or can start‐ups add them as needed along the way? Using a unique panel dataset covering Sweden's population of start‐ups from 1997 to 2012, our analys

The extensive peat bogs of Southern Scandinavia have yielded rich Mesolithic archaeological assemblages, with one of the most iconic artefacts being the bone point. Although great in number they remain understudied. Here we present a combined investigation of the typology, protein-based species composition, and absolute chronology of Maglemosian bone points. The majority of the bone points are mad

Intestinal ischaemia is usually classified into acute mesenteric ischaemia (AMI), chronic mesenteric ischaemia and colonic ischaemia. Coeliac, inferior and superior mesenteric arterial/venous emboli/thrombi and non-occlusive mesenteric ischaemia (NOMI) can cause AMI. NOMI pathophysiology involves hypoperfusion, aggravated by bacterial translocation, reperfusion injury, apoptosis and decreased prol

OBJECTIVES: To evaluate the systemic phenotype associated with the presence of isolated anti-La/SSB antibodies in a large international registry of patients with primary Sjögren's syndrome (pSS) fulfilling the 2002 classification criteria.METHODS: The Big Data Sjögren Project Consortium is an international, multicentre registry created in 2014. Baseline clinical information from leading centres on

During World War II, middle-distance runner Gunder Hägg set 15 world records and became a media sport star of unprecedented magnitude in Sweden. This article turns attention to the role of radio broadcasts in the formation of Swedish “Hägg mania” 1941–45. When analyzed in terms of blindness, liveness and co-presence, radio broadcasts from this era reveal that radio announcers actively engaged with

Det har länge varit en kliché att vetenskapen utgör det nutida samhällets andliga stånd. Men vad betyder det, och hur väl håller denna metafor?Även om det kan ligga något i bilden av ett vetenskapligt prästerskap, är det också viktigt att notera på vilka sätt den är vilseledande. Forskare finner det ofta fåfängt att försöka nå Sanningen. I stället försöker de förkasta det som är falskt. På så sätt

Background: Specific medical guidelines for health surveillance exist for people with Down syndrome (DS) since 25 years but knowledge of adherence to the guidelines is lacking. The guidelines were developed to avoid unnecessary suffering from preventable conditions. The aims of the study were to investigate 1) planned health care visits in relation to the co-morbidities described in specific medic