In recent times, the philosophy of science has been reinvigorated by insights from different biological and cognitive sciences. These disciplines have provided not only new approaches to traditional philosophical problems but have also opened the door to new conceptual puzzles. The fundamental aim of this volume is to bring together some of the main debates that have structured the fields of philo

Background: The water supply in the Gaza Strip, Palestine, has been unstable and under strain for decades, resulting in major issues with drinking water quality, reliability, and acceptability. In 2018, between 25% and 30% of Gazans did not have regular access to running water. The progressive deterioration of water infrastructure and concerns over the quality of piped water have resulted in a com

In recent years, stochastic partial differential equations (SPDEs) have become a well-studied field in mathematics. With their increase in popularity, it becomes important to efficiently approximate their solutions. Thus, our goal is a contribution towards the development of efficient and practical time-stepping methods for SPDEs. Operator splitting schemes provide powerful, efficient, and flexibl

Reactive oxygen species (ROS) are considered to be an indicator of particle-induced toxicity. We used a novel instrument, called Particle Into Nitroxide Quencher (PINQ), for real-time quantification of ROS for assessment of indoor particle sources. Of the sources tested, cigarette smoke was found to contain the highest ROS concentration, several times higher than incense smoke and secondary organi

Rodent models are important research tools for studying the pathophysiology of traumatic brain injury (TBI) and developing new therapeutic interventions for this devastating neurological disorder. However, the failure rate for the translation of drugs from animal testing to human treatments for TBI is 100%. While there are several potential explanations for this, previous clinical trials have reli

The building and construction sector is responsible for a significant portion of embodied and energy related carbon emissions. Efforts to reduce this are reflected in the need for improved sustainability in the design, construction, and operation of structures such as buildings and bridges. This issue has become more prominent in recent decades due to the ongoing climate crisis. A historical revie

Objective: This study examined the prevalence and long-term survival of atrial fibrillation (AF) in the older population. Methods: Data was recruited from the longitudinal SNAC study from baseline (2001–2004) for up to 10 years. Results: The population comprised 6,904 persons (59% women) (mean age 73.9 years). The prevalence of AF was 4.9% and increased with age. The hazard ratio (HR) for death in

This paper presents a method for evaluating the potential for injury in any traffic scenario involving road user interactions based on trajectory data from a few hours of data of typical traffic conditions. The basic idea was to evaluate to what extent interactions at a location are limited in speed, direction, and whether the interactions happen at a safe speed. Specifically, the method works by

Recently approved anti-amyloid immunotherapies for Alzheimer's disease (AD) require evidence of amyloid-β pathology from positron emission tomography (PET) or cerebrospinal fluid (CSF) before initiating treatment. Blood-based biomarkers promise to reduce the need for PET or CSF testing; however, their interpretation at the individual level and the circumstances requiring confirmatory testing are p

This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state-of-the-art protocols for the preparation, phenotype analysis by flow cytometry, generation, fluorescence microscopy, and functional characterization of mouse and human dendritic cells (DC) from lymphoid organs, and various nonlymphoid tissues. Within this article, detailed protocols are prese

Background: A unique form of hemophilia B (HB) is HB Leyden. We evaluated the international Pediatric Network on Hemophilia Management Registry (PedNet) database to explore the natural history of HB Leyden, investigate genotype-phenotype associations, and guide clinical decision-making. Objectives: To assess the association between genetic variants, endogenous factor (F)IX levels over time, treatm

The results of the investigation of radiation hazard of forest fires in the radioactive contaminated areas in the article are presented. The activity concentration of long-lived radionuclides in forest fuel materials is shown. Airborne concentration of 137Cs produced by the combustion of forest fuel materials with different contamination density can exceed the permissible activity levels of 137Cs

Atrial fibrillation (AF) is a complex condition caused by various underlying pathophysiological disorders and is the most common heart arrhythmia worldwide, affecting 2 % of the European population. This prevalence increases with age, imposing significant financial, economic, and human burdens. In Europe, stroke is the second leading cause of death and the primary cause of disability, with numbers

Purpose: To evaluate inter- and intrarater reliability, of the Eating and Drinking Ability Classification System (EDACS) for children and adults with cerebral palsy (CP) in Sweden. Methods: Four speech and language pathologists rated EDACS from videos of 30 individuals with CP, 3 to 62 years, (mean 21 y, 10 m, SD 18 y, 6 m), six at each level of the Gross Motor Function Classification System (GMFC

Context: In a cross-sectional study, we found an association between type 2 diabetes mellitus (T2DM) and smaller bone area together with greater bone mineral density (BMD) at the total hip.Objective: This work aims to investigate these associations longitudinally, by studying T2DM status (no T2DM n = 1521, incident T2DM n = 119, or prevalent T2DM n = 106) in relation to changes in total hip bone a

Background: Outcome measurement is essential to progress clinical practice and improve patient care. Aim: To develop a Core Outcome Set for best care for the dying person. Design: We followed the Core Outcome Measures in Effectiveness Trials (COMET) Initiative guidelines, which involved identifying potential outcomes via a systematic literature review (n = 619 papers) and from participants in the