Frequent activation of CArG binding factor-A expression and binding in N-methyl-N-nitrosourea-induced rat mammary carcinomas
We previously identified a positive transcriptional element identical to human Ha-ras response element ( HRE) within the promoter of the rat Ha-ras gene. We further identified CArG binding factor A ( CBF-A), a member of heterogeneous nuclear ribonuclear protein ( hnRNP) gene family, as a trans-acting factor that binds the HRE sequence with high affinity in rat mammary carcinoma cells. To determine