A State of the Art lecture titled “The role of platelets in sepsis” was presented at the ISTH congress in 2020. Sepsis is a life-threatening organ dysfunction caused by a dysregulated and multifaceted host response to infection. Platelets play a significant role in the coordinated immune response to infection and therefore in the inflammation and coagulation dysfunction that contributes to organ d

Objectives: The National Institutes of Health Stroke Scale (NIHSS) has not been validated to diagnose aphasia in the stroke population. We therefore examined the diagnostic accuracy of NIHSS for detecting aphasia in acute ischemic stroke. Methods: Consecutive patients with acute first-ever ischemic stroke were included prospectively in Lund Stroke Register Study at Skåne University Hospital, Swede

In 1833-1874, Spain suffered 0.7 coups per year. By contrast, the Restoration (1874-1923) saw the eradication of successful coups. This can be partially attributed to the turno pacífico, which allowed the main political parties to alternate in office without dragging the military into politics. We suggest, however, that the reduction in coup risk was also associated with a conscious budget policy.

The traditional method for recycling brass chips is to send the scrap back to the material manufacturer for re-melting. Alternatively, brass chips can be reclaimed through hot forging operations at the production site. As an initial screening of the environmental impact of this novel reclamation method, the impacts of this new method was compared to conventional brass production (including recycli

Purpose: To explore associations between the characteristics of people with epilepsy (PWE) and their attitudes toward generic substitution of antiseizure drugs (ASDs) in epilepsy. Methods: This was a cross-sectional survey study directed at adults with epilepsy using selected brand drugs: Keppra®, Lamictal®, Lyrica® or Topimax®. Symptoms of anxiety and depression, sense of self-efficacy, and belie

Research Question/Issue: On the basis of a dynamic interrelation between the assumptions of agency theory and stewardship theory, this study seeks to make sense of disobedience at the highest corporate level. Departing from a processual view in order to better understand how loyalty plays a critical role in the relationships between a CEO and his/her principal, we propose a conceptualization of th

This article analyses the nature of policy debates on financial regulation during the onset of the Global Financial Crisis (GFC) by considering three elements that shape them: the salience of the debate, the actors that dominate the debate, and the degree of anti-status quo pressure. Theoretically, it contributes to Culpepper’s quiet/noisy politics framework by clarifying its multidimensionality a

Fulfilling the potential of colloidal semiconductor quantum dots (QDs) in electrically driven applications remains a challenge largely since operation of such devices involves charged QDs with drastically different photophysical properties compared to their well-studied neutral counterparts. In this work, the full picture of excited state dynamics in charged CdSe QDs at various time scales has bee

Introduction: Adults with spinal cord injuries are living longer than previously, and a majority are living in ordinary housing in the community. Housing accessibility is important for maintaining independent occupational performance for this population, but knowledge in this area is insufficient. We investigated housing adaptations and current accessibility problems among older adults with long-s

We report the use of multinodal acoustic trapping for high throughput and high capacity capturing of EV's (extracellular vesicles) for quantitative mass spectrometry analysis. The multinode trapping unit was shown to isolate sufficient amount of EV's from dilute biological samples (urine and cell culture supernatant) at flow rates of 500 ul/min within minutes, enabling EV proteome profiling. This

Medial temporal lobe (MTL) atrophy is an important morphological marker of many dementias and is closely related to cognitive decline. In this study we aimed to characterize longitudinal progression of MTL atrophy in 93 individuals with subjective cognitive decline and mild cognitive impairment followed up over six years, and to assess if clinical rating scales are able to detect these changes. Al

Objectives: The First-time Injurious Fall (FIF) screening tool was created to identify fall risk in community-living older adults who may benefit from primary preventive interventions. The aim of this study was to evaluate the predictive performance of the FIF tool in 2 cohorts of older adults. Design: Longitudinal cohort study. Setting and Participants: The Swedish National Study on Aging and Car

Ikaros is an open framework for system-level brain modeling and real-time robot control. Version 2 of the system includes a range of computational components that implements various algorithms and methods ranging from models of neural circuits to control systems and hardware interfaces for robot. Ikaros supports the design and implementation of large-scale computation models using a flow programmi

Purpose: We have summarized key studies regarding the assessment of subclinical macroangiopathic target organ damage (TOD) in type 1 diabetes mellitus (T1DM). Results: Although chronic complications resulting from hyperglycemia, in particular macroangiopathies, are still the first cause of death in T1DM, there has been growing recognition of the role of hypoglycemia in cardiovascular morbidity and

As researchers we are often faced with the difficult and demanding task of preparing models, and their computer implementations, for decision making, or, more recently, for integrated assessment. Such assessment often involves large scale problems, where the decisions to be made can deeply affect the environment, the social context and the economic background of regions and even nations. Yet, we f

As climate models can be used to reproduce historical climates, the outcomes can be used to put climate extremes in to a proper historical perspective. This also allows investigation of nonlinear properties of hydrologic processes (e.g. precipitation, runoff) to better understand regional hydrologic dynamics. To this end, the present study uses results from a so-called 'paleosimulation' (i.e. simu

Chronic airflow limitation (CAL) can be defined as fixed ratio of forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) < 0.70 after bronchodilation. It is unclear which is the most optimal ratio in relation to respiratory morbidity. The aim was to investigate to what extent different ratios of FEV1/FVC were associated with any respiratory symptom. In a cross-sectional general populat

Great social challenges of today, and the conflicts arising therefrom, no longer come one by one. What makes them great is their entanglement in one other and across multiple levels. Similarly, spatial conflicts seldom arise in isolation, but result from simmering tensions that may manifest in a more insidious fashion, namely by appealing to intangible values. This chapter looks into one such spat

Virtual Clinical Trials (VCT) are an effective tool to evaluate the performance of novel imaging systems using computer simulations. VCT results depend on the selection of virtual patient populations. In the case of breast imaging, virtual patients should be matched to a desired clinical population in terms of selected anatomical or demographic descriptors. We are developing a virtual population o