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Objectives To identify the genetic determinants of fracture risk and assess the role of 15 clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide association studies (GWAS) and a two-sample mendelian randomisation approach. Setting 25 cohorts from Europe, United States, east Asia, and Australia with genome wide genotyping and fracture data. Participants A discover

The presence of unobserved heterogeneity and its likely detrimental effect on inference has recently motivated the use of factor-augmented panel regression models. The workhorse of this literature is based on first estimating the unknown factors using the cross-section averages of the observables, and then applying ordinary least squares conditional on the first-step factor estimates. This is the

In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers are urgently needed. The diagnosis of Parkinson's disease mostly relies on clinical symptoms, which hampers the detection of the earliest phases of the disease—the time at which treatment with forthcoming disease-modifying drugs could have the greatest therapeutic effect. Reliable prognostic markers could help

Health-related quality of life (HRQL) is a multidimensional concept which captures the individual’s perception of treatment burden. Evaluating HRQL during treatment for childhood cancer provides insight into the burden of the treatment from the child’s and/or parent’s perspective.In this review, we aimed to describe Patient-Reported Outcome Measures (PROMs) used to measure HRQL during treatment, d

The end-of-life recycling of crystalline silicon photovoltaic (PV) modules and the utilisation of waste is of fundamental importance to future circular-economy societies. In the present work, the wet-chemistry synthesis route - a low-temperature dissolution-precipitation process - was explored to produce aluminosilicate minerals from waste c-Si solar cells. Nanostructured crystals were produced in

Heterogeneous patterns of genomic differentiation are commonly documented between closely related populations and there is considerable interest in identifying factors that contribute to their formation. These factors could include genomic features (e.g., areas of low recombination) that promote processes like linked selection (positive or purifying selection that affects linked neutral sites) at

Despite the initial promise of immunotherapy for CNS disease, multiple recent clinical trials have failed. This may be due in part to characteristically low penetration of antibodies to cerebrospinal fluid (CSF) and brain parenchyma, resulting in poor target engagement. We here utilized transcranial macroscopic imaging to noninvasively evaluate in vivo delivery pathways of CSF fluorescent tracers.

This paper is a summary of the discussion within the Diffractive and Low-x Physics Working Group at the 1999 Durham Collider Workshop of the interpretation of the Tevatron and HERA measurements of inclusive hard diffraction.

In-cylinder crank-angle resolved imaging of fuel and OH was obtained using planar laser induced fluorescence (PLIF) in a Homogenous Charge Compression Ignition (HCCI) engine. Investigations were carried out to ascertain the extent to which the combustion process in an HCCI engine is affected by the charge homogeneity. In the experiments, the heterogeneity of the charge was varied and the effect on

Brain lactate concentration is higher during wakefulness than in sleep. However, it is unknown why arousal is linked to an increase in brain lactate and why lactate declines within minutes of sleep. Here, we show that the glymphatic system is responsible for state-dependent changes in brain lactate concentration. Suppression of glymphatic function via acetazolamide treatment, cisterna magna punctu

The development of cognitive robots in ROS still lacks the support of some key components: a knowledge integration framework and a framework for autonomous mission execution. In this research chapter, we will discuss our skill-based platform SkiROS, that was developed on top of ROS in order to organize robot knowledge and its behavior. We will show how SkiROS offers the possibility to integrate diThe development of cognitive robots in ROS still lacks the support of some key components: a knowledge integration framework and a framework for autonomous mission execution. In this research chapter, we will discuss our skill-based platform SkiROS, that was developed on top of ROS in order to organize robot knowledge and its behavior. We will show how SkiROS offers the possibility to integrate di

Due to a general shift in manufacturing paradigm from mass production towards mass customization, reconfigurable automation technologies, such as robots, are required. However, current industrial robot solutions are notoriously difficult to program, leading to high changeover times when new products are introduced by manufacturers. In order to compete on global markets, the factories of tomorrow nDue to a general shift in manufacturing paradigm from mass production towards mass customization, reconfigurable automation technologies, such as robots, are required. However, current industrial robot solutions are notoriously difficult to program, leading to high changeover times when new products are introduced by manufacturers. In order to compete on global markets, the factories of tomorrow n

Background: The Abdominal Compartment Society (WSACS) established consensus definitions and recommendations for the management of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) in 2006, and they were last updated in 2013. The WSACS conducted an international survey between 2022 and 2023 to seek the agreement of healthcare practitioners (HCPs) worldwide on current and n

This article probes the writings of the Jewish Trotskyist thinker Daniel Bensaïd (1946–2010) in light of recent debates on political theology. In contrast to what is sometimes explicitly referred to as ‘apocalyptic political theology’, it makes a case for what may be described as a ‘prophetic political theology’. Yet it is not obvious to claim Bensaïd as a proponent for such a project, since he ex

The paper provides an overview and preliminary results from ongoing research with the aim to evolve cross-laminated timber (CLT) into the next generation of Tailored Laminated Timber (TLT). This is done by exploring innovative concepts that optimize the mechanical performance, while simultaneously ensuring adherence to circular economy principles. The current study aims at investigating the potent

The paper considers the results of experiments on the reactions 12C(γ, p)11B and d(γ, p)n in the energy range of tagged photons 35...80 MeV. Demonstrated the possibility identification of protons by ΔE - E using CsI/SSD telescope. Using the spectra of the missing energy defined the values of differential cross sections of these reactions in the range of photon energies. The good agreement of the e

For the last ten years, the notion of a green economy has become increasingly attractive to policy makers. However, green economy covers a lot of diverse concepts and its links with sustainability are not always clear. In this article, we focus on definitions of green economy and related concepts and an evaluation of these concepts against the criterion of strong and weak sustainability. The artic

While recent experimental frameworks for national ecosystem service accounting have shown substantial progress, in our view some crucial methodological issues remain that deserve further consideration before setting final standards. In response to the landmark work of Obst et al. (Environ Resour Econ 64:1–23, 2016. doi: 10.1007/s10640-015-9921-1), we provide arguments with regard to the suitabilit

The Green Economy is a strategic development concept of the United Nations incorporating a broad array of potential meanings and implications. It is subject to academic conceptualisation, operationalisation, reflection and criticism. The aim of our paper is to conceptualise a subset of the multi-faceted and at times polarised debate around the implications and applications of the Green Economy con

Study Design: Qualitative study. Introduction: An amputation injury to the hand may lead to not only impaired hand function but also psychosocial consequences. Purpose of the Study: The purpose of the study was to explore personal experiences of social participation for persons provided with an esthetic prosthesis after acquired upper limb amputation. Methods: Thirteen persons with acquired upper