Filtyp
We present a trinification-based grand unified theory incorporating a global SU(3)F family symmetry, that after spontaneous symmetry breaking leads to a left-right symmetric model. In addition to unification of gauge couplings, the model unifies Yukawa interactions and contains equivalent representations in the scalar and fermion sectors at high energy scales. Considering the minimal low-energy sc
Aims/hypothesis: P-element induced Wimpy testis (PIWI)-interacting RNAs (piRNAs) are small non-coding RNAs that interact with PIWI proteins and guide them to silence transposable elements. They are abundantly expressed in germline cells and play key roles in spermatogenesis. There is mounting evidence that piRNAs are also present in somatic cells, where they may accomplish additional regulatory ta
We study the initial-state interactions (non-coherence) and nuclear shadowing (coherence) effects in the Drell-Yan pair production process in p+Pb collisions at the LHC energies. The analysis of the nuclear suppression, RpA < 1, has been performed in the color dipole approach in the large coherence length approximation. The Z0 boson contribution relevant at large dilepton invariant masses has been
Triple-negative breast cancer (TNBC) patients commonly exhibit poor prognosis and high relapse after treatment, but there remains a lack of biomarkers and effective targeted therapies for this disease. Here, we report evidence highlighting the cell-cycle–related kinase CDK7 as a driver and candidate therapeutic target in TNBC. Using publicly available transcriptomic data from a collated set of TNB
BACKGROUND: Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating condition resulting from a sustained lack of oxygen during birth. The interest in identifying a relevant biomarker of HIE has thrown into limelight the role of protein S100B as a clinical diagnostic marker of hypoxic brain damage in neonates.AIMS: To evaluate the diagnostic value of protein S100B, measured in umbilical cor
The problem of finding the controller that optimizes the expected H2-norm of an uncertain system is solved in closed form for a class of problems including such signal processing applications as feedforward design, channel equalization, noise cancellation etc. The method uses covariance information on model uncertainty and does therefore match information obtainable from standard system identifica
Background: The aim of this study was to explore trends in treatment with antipsychotic medication in Swedish dementia care in nursing homes as reported in the most recent empirical studies on the topic, and to relate these trends to directives from the national authorities. Methods: The study included two scoping review studies based on searches of electronic databases as well as the Swedish dire
BACKGROUND—: Myeloid cells are central to atherosclerotic lesion development and vulnerable plaque formation. Impaired ability of arterial phagocytes to uptake apoptotic cells (efferocytosis), promotes lesion growth and establishment of a necrotic core. The transcription factor Interferon Regulatory Factor (IRF)-5 is an important modulator of myeloid function and programming. We sought to investig
Background: At birth, infants' lungs are fluid-filled. For newborns to have a successful transition, this fluid must be replaced by air to enable effective breathing. Some infants are judged to have inadequate breathing at birth and are resuscitated with positive pressure ventilation (PPV). Giving prolonged (sustained) inflations at the start of PPV may help clear lung fluid and establish gas volu
Mass transfer in infinite parallel-plate dialyzers with co-flow between sample and detector streams is discussed for three different theoretical models. Analytical solutions with coupled diffusion and membrane transfer equations were obtained for plug flow in both channels. The finite-difference approximation method was used to obtain numerical solutions for a laminar-flow regime. Results obtained
Simultaneous optimisation of several criteria is an important and interesting subject. Even the standard H2-case is non-trivial. The problem is here treated for the general MIMO case for two conflicting objectives (the results directly generalise to several performance measures). A seminorm D2 is introduced to describe the situation. The state-space solution technique in [Khargonekar and Rotea, 19
Economic divisions have deepened in Sweden in recent years, and lone mothers are one group where the poverty rate has increased most (Salonen 2014). At the same time, di erences between the situations of lone mothers have also increased (Lundqvist 2014). As a consequence, intergenerational support from grandparents in terms of care and nancial transfers are important (see also Halleröd 2008). Thi
BACKGROUND Clonal hematopoiesis of indeterminate potential (CHIP), which is defined as the presence of an expanded somatic blood-cell clone in persons without other hematologic abnormalities, is common among older persons and is associated with an increased risk of hematologic cancer. We previously found preliminary evidence for an association between CHIP and atherosclerotic cardiovascular diseas
Background: Arterial hypertension is common in adults with repaired coarctation of the aorta, and is associated with several severe complications. Aims: This study aimed to investigate the prevalence of poorly controlled (⩾140/90 mmHg) blood pressure among patients with diagnosed hypertension and to identify associated factors. Methods: In the national register for CHD, adults with repaired coarct
OBJECTIVE:: Carotid–femoral pulse wave velocity (CFPWV), a marker of aortic stiffness, has been associated with cognitive test results and markers of cerebral small vessel disease, but its association with dementia has not been studied in detail. Our aim was to assess the association of CFPWV with prevalent and incident dementia in a large population-based study. METHODS:: In total, CFPWV was meas
Six exposures to 95 % CO2 for one minute were made in four pigs. Following onset of CO2-inhalation muscle jerks were observed after a latency of about 15 s. At this time the EEG showed a slow wave pattern typical of general anaesthesia. The short latency muscle jerks were by all probability no emotional stress reactions, but instead the motoric manifestation of a release phenomenon. Therefore, it
Background: Very little is known about the dermal uptake of isocyanates, and dermal exposure to isocyanates has been discussed as a factor involved in the induction of respiratory diseases. Objectives: To investigate the dermal uptake of diphenylmethane-4,4’-diisocyanate (4,4’-MDI). Materials & Methods: Four volunteers were dermally exposed to 10, 25, 49 and 50 mg 4,4’-MDI, respectively, for e
To study the association between country of birth and incident atrial fibrillation (AF) in several immigrant groups in Sweden. The study population included all adults (n = 3,226,752) aged 45 years and older in Sweden. AF was defined as having at least one registered diagnosis of AF in the National Patient Register. The incidence of AF in different immigrant groups, using Swedish-born as referents
Purpose: The FANCM c.5101C>T nonsense mutation was previously found to associate with breast cancer in the Finnish population, especially among triple-negative cases. Here, we studied the prevalence of three other FANCM variants: c.5791C>T, which has been reported to predispose to familial breast cancer, and the c.4025_4026delCT and c.5293dupA variants recently identified in Finnish cancer patient
