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In this issue of Cell Stem Cell, Márquez-Valadez, Gallardo-Caballero, and Llorens-Martín1 report that adult hippocampal neurogenesis (AHN) is differentially disrupted in neuropsychiatric disorders. Their findings highlight the role of the neurogenic niche and lifestyle, supporting the view of human AHN as a dynamic process sensitive to biology and behavior.
Transfecting clonal beta cells with large DNA plasmids holds significant promise for diabetes research. Existing transfection techniques like lipofection, viral transduction, and bulk electroporation often face limitations such as low efficiency and cytotoxicity. Nanoelectroporation, which utilizes nanopores or nanostraws and the application of mild electrical pulses, offers a gentle and safe alte
In the physical product development context, agile practices, particularly agile teams, are seldom applied as originally intended. They are often equated with traditional project teams, which conflicts with the fundamental principles of agile teams, undermining several associated benefits. Unlike traditional project teams, agile teams are ideally stable, focusing on continuously delivering value t
The thermal regime is a key indicator of permafrost evolution and thaw trajectories in response to climate change but remains poorly represented in global models. In this study, we applied the Moving-Grid Permafrost Model (MGPM), an efficient numerical model, to simulate the permafrost thermal regime in West Kunlun (WKL), a 55 669 km2 region on the remote northwestern Qinghai-Tibet Plateau charact
Rationally designing and fabricating high-performance core–shell nanostructures for catalytic organic synthesis is significant yet challenging. Here, we report a solvothermal/calcination strategy to prepare novel core–shell iron–aluminum oxide (FeAlOx) nanosphere-based nanoreactors incorporating active heterometals (AHM = Pd, Cu, or Mn). Leveraging the synergistic benefits of their unique core–she
The implementation of low-carbon futures requires both the assembling of new technologies, and practices, as well as the ‘unmaking’ of extant high-carbon infrastructures. Here, we bring together geographical, STS, anthropological, and sociological thinking on time to re-conceptualise such processes of unmaking. We argue that a focus on temporalities is especially pertinent to the unmaking of mater
Designkort för mobil utvecklingDesign cards supporting mobile development
Poster som illustrerar mobil användningPoster illustrating mobile user experiences
Background: People with hemophilia (PwH) or von Willebrand disease (VWD) are at risk of joint bleeding, which can lead to hemophilic arthropathy. Point-of-care musculoskeletal ultrasound (POC-MSKUS) is increasingly used to detect joint bleeds, but a comprehensive compilation of available independent scanning protocols and their respective measurement properties is missing. Objectives: This study a
Using structural properties of groups of small order, we establish the non-existence of varieties isogenous to a higher product of dimension n greater than 3 with fixed topological Euler number (-2)n and trivial first Betti number.
This paper examines the causal effect of public discourse in one or both sides of the market on overall market socially responsible behavior. In a laboratory setting, we vary whether firms and/or consumers participate in a public discussion before trading begins. When both sides take part, the share of socially responsible trades increases slightly; however, when only one side participates, market
Sexual conflict frequently gives rise to adaptations that increase male reproductive success at the expense of harming females (“male harm”) and decreasing population growth. Studying the ecology of male harm is paramount to understand how sexual conflict unfolds in nature, and its consequences for populations viability. Here, we used seed beetles (Callosobruchus maculatus), a species where males
Many studies that use an automated sorption balance to determine a water vapor sorption isotherm for wood collect data until the moisture content change is less than or equal to 0.002% min−1 (20 µg g−1 min−1). This stop criterion has been claimed to give errors in equilibrium moisture content (EMC) predictions of less than 0.001 g g−1 but over the past 10 years, studies have shown that the actual
We present a finite-volume QED action designed to improve the infinite-volume extrapolation of hadronic observables in precision lattice QCD+QED calculations. The action proposed in this work, which we call QEDr, can be seen as a particular case of the infrared-improved QED actions introduced by Davoudi et al. in 2019, and is specifically designed to remove kinematics-independent finite-volume cor
This project seeks to contribute to the ongoing shift in how we respond to climate change—approaching it with the urgency it demands. It is located in Vienna’s 15th district and builds on spatial analysis, mapping of underused areas, and a contextual reading of socio-climatic conditions to highlight both spatial restrictions and hidden potentials. The selected site serves as a test field for a vis
This thesis proposes a new architectural approach for elderly housing in Selfoss, a town located approximately 45-50 minutes from Reykjavík. It is experiencing increased housing demand due to its growth as a service and commuter hub. Rather than directly adopting common local apartment typologies, the project reconsiders their form, spatial qualities, and relationship to the site, aiming to meet t
Background Alzheimer's disease (AD) may cause significant psychosocial distress not only in the patient but also their partner. However, long-term risks of major depression in partners of AD patients are largely unknown. Methods A national cohort study was conducted of all 145 289 partners of people diagnosed with all-cause dementia, including 57 113 partners of people diagnosed with AD, in Sweden
