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Apolipoprotein A-I (ApoA-I) of high density lipoproteins (HDLs) is essential for the transportation of cholesterol between peripheral tissues and the liver. However, specific mutations in ApoA-I of HDLs are responsible for a late-onset systemic amyloidosis, the pathological accumulation of protein fibrils in tissues and organs. Carriers of these mutations do not exhibit increased cardiovascular di
Background. Solid organ transplants (SOTs) are life-saving interventions, recently challenged by coronavirus disease 2019 (COVID-19). SOTs require a multistep process, which can be affected by COVID-19 at several phases.Methods. SOT-specialists, COVID-19-specialists, and medical ethicists designed an international survey according to CHERRIES guidelines. Personal opinions about continuing SOTs, sa
Methane and hydrogen-enriched (25 vol% and 50 vol% H2-enriched CH4) methane/air premixed flames were investigated in a gas turbine model combustor under atmospheric conditions. The flame operability ranges were mapped at different Reynold numbers (Re), showing the dependence on Re and H2 concentrations. The effects of equivalence ratio (Φ), Re, and H2 enrichment on flame structure were examined em
Aims: Accurate and reliable diagnosis is essential for lung cancer treatment. The study aim was to investigate interpathologist diagnostic concordance for pulmonary tumours according to WHO diagnostic criteria. Methods: Fifty-two unselected lung and bronchial biopsies were diagnosed by a thoracic pathologist based on a broad spectrum of immunohistochemical (IHC) stainings, molecular data and clini
Purpose: In 2017, the Geneva Alzheimer’s disease (AD) Biomarker Roadmap initiative adapted the framework of the systematic validation of oncological diagnostic biomarkers to AD biomarkers, with the aim to accelerate their development and implementation in clinical practice. With this work, we assess the maturity of [18F]flortaucipir PET and define its research priorities. Methods: The level of mat
The article focuses on the entanglement between the EU’s attempts to construct its external actions in global politics and research on the EU as a global actor. The article argues that both the development of EU external actions and the sociology of knowledge production surrounding the analysis of these actions suffer from unnecessary dichotomisation. Advocates and analysts of the EU’s normative p
In an era of European crises over political legitimacy, economic austerity, and collapse of confidence in the EU the topic of European integration has be-come a very emotional subject. The anger which protestors demonstrate against economic austerity, the hate which nationalist far-right parties express for the EU and fellow Europeans, and the passion with which supporters of the EU argue for grea
Denna avhandling utforskar den stratosfäriska aerosolen genom både in-situ mätningar och fjärranalys. Bakgrundsaerosolen är komplex och påverkas av injektioner av skogsbrandrökspartiklar och av partiklar skapade från vulkaniskt SO2. Klimatmodeller behöver träffsäkra beskrivningar av den stratosfäriska aerosolen för att ha rimliga strålningsbudgetar. Genom att använda fjärranalystekniken satellitbuThis thesis explores the stratospheric aerosol through both in-situ measurements and remote sensing. The background stratospheric aerosol is complex and is perturbed by injections of forest fire smoke particles and by particles formed from volcanic SO2. Climate models need accurate description of the stratospheric aerosol in order to have sound radiation budgets. Using the remote sensing technique
Background: Limited information is available regarding intraoperative ventilator settings and the incidence of postoperative pulmonary complications (PPCs) in patients undergoing neurosurgical procedures. The aim of this post-hoc analysis of the 'Multicentre Local ASsessment of VEntilatory management during General Anaesthesia for Surgery' (LAS VEGAS) study was to examine the ventilator settings o
Background: Although survivors of childhood cancer are at risk of chronic pain, the impact of pain on daily functioning is not well understood. Methods: A total of 2836 survivors (mean age, 32.2 years [SD, 8.5 years]; mean time since diagnosis, 23.7 years [SD, 8.2 years]) and 343 noncancer community controls (mean age, 35.5 years [SD, 10.2 years]) underwent comprehensive medical, neurocognitive, a
