PurposeGermline genetic testing for BRCA1 and BRCA2 variants has been a part of clinical practice for >2 decades. However, no studies have compared the cancer risks associated with missense pathogenic variants (PVs) with those associated with protein truncating (PTC) variants.MethodsWe collected 582 informative pedigrees segregating 1 of 28 missense PVs in BRCA1 and 153 pedigrees segregating 1 of

Background: Adolescence is associated with different feelings and experiences that can negatively affect adolescents’ health and well-being. In the transition between childhood and adulthood, experiences of loneliness are common. A deep form of loneliness is described as existential loneliness. Studies among adults have shown that existential loneliness often arises in connection with transitions

Field-resolved two-dimensional spectroscopy reveals the sub-cycle gain dynamics of a free-running terahertz quantum cascade laser and disentangles resonantly enhanced nonlinearities up to eight-wave mixing in a regime where gain replaces absorption.

Professionaliseringen av diplomatin skedde genom en lång process vars start ofta placeras vid slutet av den Westfaliska freden och 1700-talets slut. Denna professionaliseringsprocess var komplex eftersom den formades av de aktiva diplomaterna, deras livserfarenheter, och av tidsspecifika normer förankrade i ritualer och dokumentation, samt därtill av förändringar kopplade till allt tydligare socia

As the number of antennas scales up, research efforts have been directed towards finding decentralized receiver solutions for multi-antenna architectures. In a recent paper, a novel matrix decomposition - the WAX decomposition - was proposed, which has direct bearing on characterizing the level of decentralization that is possible if the complexity of the decentralized processing is limited. Howev

Solar access describes the amount and distribution of sunlight in living environments. Access to sunlight is crucial for the health and sustainability of cities. It is vital for people and vegetation, and for energy production and conservation. The amount of sunlight entering the city space is restricted by the urban layout, as buildings obstruct solar access by shading each other and the surround

The European Solar Telescope (EST) is a project aimed at studying the magnetic connectivity of the solar atmosphere, from the deep photosphere to the upper chromosphere. Its design combines the knowledge and expertise gathered by the European solar physics community during the construction and operation of state-of-the-art solar telescopes operating in visible and near-infrared wavelengths: the Sw

Infrared drying characteristics and quality variations (color change, hardness, contents of polyphenol and flavonoid) of lily bulbs under blanching pretreatment are investigated. Influences of parameters such as pretreatment temperature and time and infrared drying temperature are discussed. Effective moisture diffusivity coefficient, activation energy, and energy consumption were calculated. Resu

Background: Subregions in the medial temporal lobe (MTL) are affected early by Alzheimer’s disease (AD) pathology and subject to grey matter atrophy. Measuring the earliest AD-related atrophy in the hippocampus is challenging as region-of-interest (ROI) analyses of hippocampal subregional volumes collapse across voxels within anatomical subregions. PET imaging studies, however, report accumulation

How do Chinese queer artists respond to the hegemony of Han-centric, patriarchal, and heterosexual norms, and how do they imagine home through a queer and activist lens? This study explores the visual representation of the queer community by veteran artist/activist couple Shitou and Mingming through an analysis of the photographs and documentaries shot by the artists and their friends since the 19