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Deficiencies of the early complement components of the classical pathway (CP) are well-documented in association with systemic lupus erythematosus (SLE) or SLE-like syndromes and severe pyogenic infections. Among these, complete C1s deficiency has been reported in nine cases so far. Here, we describe a 34-year-old male patient who presented with severe, recurrent infections since childhood, includ

Snapshot spectral imaging enables the acquisition of hyperspectral images (HSI) employing specialized optical systems, such as the coded aperture snapshot spectral imager (CASSI). Specifically, the CASSI system performs spatiospectral codification of light obtaining two-dimensional projected measurements, and these measurements are then processed by computational algorithms to obtain the desired s

Smallholder farmer-based rural social movements have been heralded as a promising source of political power with the potential to effectively promote sustainable trajectories of agricultural development in Sub-Saharan Africa and beyond. However, the very early stages of rural social movement building remain understudied, including under what conditions such nascent efforts are likely to lead to ef

Most children grow up in urbanised settings with a low possibility to experience biodiversity and nature. However, experiencing nature and other species increases children’s wellbeing, health, learning abilities and their understanding of nature values. Play biotopes is one solution for supporting a co-existence between children and different species in nature-based play settings. Play biotopes ar

Intensivvårdsavdelningen (IVA) tar hand om de mest kritiskt sjuka patienterna, ofta med multiorgansvikt. Denna patientgrupp kräver kontinuerlig övervakning av vitala funktioner som blodtryck, EKG och syremättnad. Varje patient på IVA kräver dessutom upprepad provtagning, ibland så ofta som var 15:e min. Denna ständiga övervakning leder till insamling av mycket patientdata som varje läkare/sjukvård

Increasing imperviousness in urban areas, and changes in rainfall intensity and return periods because of climate change increase urban flood risk. This study utilizes the hydraulic model Mike+ to assess the multifunctional use of existing roads and parking lots, which could serve to either retain or detain stormwater and accommodate trees, plants, and vegetation as part of a low-impact developmen

Riparian buffer zones (RBZs) are an important instrument for environmental policies for water and biodiversity protection in managed forests. We investigate the variation of the cost of implementing RBZs within different property size classes across the size range of non-industrial forest owner properties in Southern Sweden. Using the Heureka PlanWise decision support system, we quantified the cos

PurposeA large number of studies indicate that coercive forms of organizational control and performance management in health care services often backfire and initiate dysfunctional consequences. The purpose of this article is to discuss new approaches to performance management in health care services when the purpose is to support innovative changes in the delivery of services.Design/methodology/a

Many studies have suggested that the neocortex operates as a global network of functionally interconnected neurons, indicating that any sensory input could shift activity distributions across the whole brain. A tool assessing the activity distribution across cortical regions with high temporal resolution could then potentially detect subtle changes that may pass unnoticed in regionalized analyses.

We present a tool for modeling conflict situations that enables simulation and testing of situation awareness in shared autonomy, in this case in an autonomous driving scenario. The flexibility of the tool allows definition of new conflict situations, integration with various control and conflict detection systems, as well as customization of Takeover Request (TOR) signals and different means of c

Aims: To identify individuals with incidental fatty liver disease (FLD), and to evaluate its prevalence, metabolic co-morbidities and impact on follow-up. Methods: We leveraged the data-lake of Helsinki Uusimaa Hospital district (Finland) with a population of 1.7 million (specialist and primary care). A phrase recognition script on abdominal imaging reports (2008–2020) identified/excluded FLD or c

Several authors have described how the formalization of recent decades has steered doctoral education towards structured curricula, more managerial control and new models for supervision. Largely absent from these accounts, however, is if and how doctoral education has been affected by the concurrent changes in research governance, in particular by the ‘projectification’ of research. For this studSeveral authors have described how the formalization of recent decades has steered doctoral education towards structured curricula, more managerial control and new models for supervision. Largely absent from these accounts, however, is if and how doctoral education has been affected by the concurrent changes in research governance, in particular by the ‘projectification’ of research. For this stud

Background: Obsessive-compulsive disorder (OCD) and co-occurring posttraumatic stress disorder (PTSD) is associated with more severe and chronic OCD. However, findings regarding treatment effectiveness of cognitive behavioral treatment (CBT) with exposure and response prevention (ERP) with this comorbidity are mixed. Research aimed at understanding the precise barriers to OCD treatment effectivene

β-mannanases are pivotal enzymes that cleave the mannan backbone to release short chain mannooligosaccharides, which have tremendous biotechnological applications including food/feed, prebiotics and biofuel production. Due to the high temperature conditions in many industrial applications, thermophilic mannanases seem to have great potential to overcome the thermal impediments. Thus, structural an

Background: The number of pregnant women with congenital heart disease (CHD) is rising, and the disease poses increased risks of cardiovascular and obstetric complications during pregnancy, potentially impacting breastfeeding success. This study aimed to investigate breastfeeding in primiparous women with CHD compared to primiparous women without CHD, and to examine potential hindering factors for

This report will discuss how principles from the advanced physics of cryogenics influenced my composition Der Rufer for percussion quartet. In this paper I explain how I translated information and concepts from superfluid helium (He II) to music composition. Achieved using different methods ranging from purely intuitive to quasi-quantitative, I transferred the following eight principles from ultra

Objective To investigate the time to first childbirth and to compare the prevalence of assisted reproductive treatment (ART) in women with congenital heart disease (CHD) compared with women without CHD. Methods All women in the national register for CHD who had a registered first childbirth in the Swedish Pregnancy Register between 2014 and 2019 were identified. These individuals (cases) were matc

Adaptation is central to address climate impacts. At present, we have a limited understanding of the effectiveness of adaptation to reduce risks in a warming world, because adaptation remains insufficiently addressed in climate impact projections. Where projections exist, these are assessed mostly in case study settings. The importance of water is apparent within the field of climate adaptation, w