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Targeted proteomics for the indirect detection of dexamethasone treatment in bovines

The illegal use of pharmacologically active compounds for growth promotion in food-producing species poses risks for consumer health and animal welfare. Surveillance relies on the quantification of drug residues in animal fluids or tissues, but the efficacy can be negatively affected due to undetectable residual concentrations in biological matrices. Consequently, techniques focusing on the indire

Femoral Strength Prediction using Finite Element Models : Validation of models based on CT and reconstructed DXA images against full-field strain measurements

Osteoporosis is defined as low bone density, and results in a markedly increased risk of skeletal fractures. It has been estimated that about 40% of all women above 50 years old will suffer from an osteoporotic fracture leading to hospitalization. Current osteoporosis diagnostics is largely based on statistical tools, using epidemiological parameters and bone mineral density (BMD) measured with du

Deciphering the structure of the West Greenland marine food web using stable isotopes (δ13C, δ15N)

The Arctic is facing major environmental changes impacting marine biodiversity and ecosystem functioning. One way of assessing the responses of an ecosystem to these changes is to quantitatively study food web dynamics. Here, we used stable isotope (δ15N and δ13C) analyses of 39 Arctic marine species to investigate trophic relationships and isotopic niches of the West Greenland food web in 2000–20

Trimethylboron as single-source precursor for boron-carbon thin film synthesis by plasma chemical vapor deposition

Boron-carbon (BxC) thin films are potential neutron converting layers for 10B-based neutron detectors. However, as common material choices for such detectors do not tolerate temperatures above 500 °C, a low temperature deposition route is required. Here, we study trimethylboron B(CH3)3 (TMB) as a single-source precursor for the deposition of BxC thin films by plasma CVD using Ar plasma. The effect

Incidence of oral thrush in patients with COPD prescribed inhaled corticosteroids : Effect of drug, dose, and device

Background and aims Little information is available on real-life occurrence of oral thrush in COPD patients treated with ICS. We investigated oral thrush incidence in COPD patients prescribed FDC ICS/LABA therapies and assessed whether it is modulated by the ICS type, dose, and delivery device. Methods We conducted a historical, observational, matched cohort study (one baseline year before and one

Governance of higher education – implementation of project governance

This article focuses on coordination between governance actors in higher education. The object of the study is a department at a public university, seen as a multi-project environment. The purpose of this article is to illustrate and analyze project governance as a tool that allows departmental management to coordinate with the authorities, the board and the management at different levels at the u

Utformning av murverkskonstruktioner enligt Eurokod 6

Handboken har utarbetats som hjälp för intressenter i byggbranschen att tillämpa Eurokodsystemet på murade konstruktioner. Handboken avses bli ett stöd för projektörer och byggare som varit vana vid att använda nationella svenska byggregler, som BKR, i samband med projekt som uppförs i Sverige. Men handboken kan också vara till nytta för bedömning från beställar- och myndighetssidan av projekt som

Early ontogeny of the Furongian (Cambrian) olenid trilobites Sphaerophthalmus alatus (Boeck, 1838) and Ctenopyge (Mesoctenopyge) tumida Westergård, 1922 from Bornholm, Denmark

The early stages in ontogenetic development are described in the co-occurring Sphaerophthalmus alatus (Boeck, 1838) and Ctenopyge (Mesoctenopyge) tumida Westergård, 1922, using fragmentary but otherwise well-preserved material from Bornholm, Denmark. The former species is a senior synonym of Ctenopyge (Eoctenopyge) angusta Westergård, 1922, as has been recently proposed, but the early stages of S.

Quantitative mass spectrometry to study inflammatory cartilage degradation and resulting interactions with the complement system

Joint diseases are often characterized by inflammatory processes that result in pathological changes in joint tissues, including cartilage degradation and release of components into the synovial fluid. The complement system plays a central role in promoting the inflammation. Because several cartilage proteins are known to interact with complement, causing either activation or inhibition of the sys

FACIN, a double-edged sword of the emerging periodontal pathogen filifactor alocis : A metabolic enzyme moonlighting as a complement inhibitor

Periodontal disease is one of the most common inflammatory infectious diseases worldwide and it is associated with other syndromes, such as cardiovascular disease or rheumatoid arthritis. Recent advances in sequencing allowed for identification of novel periodontopathogens such as Gram-positive Filifactor alocis, but its virulence mechanisms remain largely unknown.We confirmed that F. alocis is a

Subliminal influence on generosity

We experimentally subliminally prime subjects prior to charity donation decisions by showing words that have connotations of pro-social values for a very brief time (17 ms). Our main finding is that, compared to a baseline condition, the pro-social prime increases donations by approximately 10–17 % among subjects with strong pro-social preferences (universalism values). We find a similar effect wh

Structure, Dynamics and Phase Behaviour of Charged Soft Colloidal Dispersions

Inom fysiken används ofta hårda sfärer som modellsystem för att beskriva beteenden och strukturer hos grundläggande byggstenar såsom atomer och molekyler. Dessa sfärer kan ses som en samling biljardbollar och kan därav bara organiseras på ett begränsat antal sätt. Med den ökade förståelsen för många komplexa fysikaliska fenomen och den snabbt växande utvecklingen av nya material behövs modellsysteSoft and deformable ionic microgels such as poly(N-isopropylacrylamide-co-acrylic acid), PNIPAM-co-AA, microgels have shown to be a versatile alternative to the already well-established hard sphere model systems. Their tuneable interaction potential makes them well suited as model systems to study the phase behaviour found for particles interacting via a soft isotropic potential. This stems from t

Brick makers, builders and commissioners as agents in the diffusion of Hellenistic fired bricks : choosing social models to fit archaeological data

The aim of this study is to understand the mechanisms behind the diffusion of fired bricks in Hellenistic Europe, initiated in the north Aegean in the 4th century BC. To this end, a social diffusion model is used to simulate the available archaeological data pertaining to this process. The starting point in the construction of the model is the assumption that different categories of people contrib

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This work is the result of an interest in realizing a study about the difficulties that Swedish students encounter when learning Spanish as a foreign language, levels A2, B1 and B2, when choosing between the tenses the imperfect and the preterit in state verbs and achievement verbs. To obtain material for this study, three different tasks were used. In the first one, the students received a story

Post-Islamism and fields of contention after the Arab Spring : feminism, Salafism and the revolutionary youth

In the aftermath of the Arab Spring, conflicts in Egypt and Tunisia over the authority to rule and the role of religion in society raised questions about these societies’ capacity for reconciling differences. In retrospect, the conflicts also raise questions about the theoretical tools used to analyse regional developments. In particular, the ‘post-Islamism’ thesis has significantly changed the de

Orphan drug policies and use in pediatric nephrology

Orphan drugs designed to treat rare diseases are often overpriced per patient. Novel treatments are sometimes even more expensive for patients with ultra-rare diseases, in part due to the limited number of patients. Pharmaceutical companies that develop a patented life-saving drug are in a position to charge a very high price, which, at best, may enable these companies to further develop drugs for

Changes in prevalence of obesity and high waist circumference over four years across European regions : the European male ageing study (EMAS)

Diversity in lifestyles and socioeconomic status among European populations, and recent socio-political and economic changes in transitional countries, may affect changes in adiposity. We aimed to determine whether change in the prevalence of obesity varies between the socio-politically transitional North-East European (Łódź, Poland; Szeged, Hungary; Tartu, Estonia), and the non-transitional Medit

Protein-dependent membrane interaction of a partially disordered protein complex with oleic acid : Implications for cancer lipidomics

Bovine α-lactalbumin (BLA) forms cytotoxic complexes with oleic acid (OA) that perturbs tumor cell membranes, but molecular determinants of these membrane-interactions remain poorly understood. Here, we aim to obtain molecular insights into the interaction of BLA/BLA-OA complex with model membranes. We characterized the folding state of BLA-OA complex using tryptophan fluorescence and resolved res

Development of a moisture safe connection for stud walls

Moisture penetration around windows and doors is a problem with serious consequences for stud walls and is a common problem regardless of facade systems. The problem has received considerable focus in recent times, as buildings using ETICS (External thermal insulation composite systems) on stud walls have been damaged by penetrating water. In the present paper a robust moisture safe prefabricated