Stem cell therapies for Parkinson’s disease (PD) have entered first-in-human clinical trials using a set of technically related methods to produce mesencephalic dopamine (mDA) neurons from human pluripotent stem cells (hPSCs). Here, we outline an approach for high-yield derivation of mDA neurons that principally differs from alternative technologies by utilizing retinoic acid (RA) signaling, inste

BACKGROUND: Female sex workers (FSW) remain a highly exposed group for HIV/STIs due to different factors including condom failure. In Ethiopia, pre-exposure prophylaxis (PrEP) has recently been introduced as an intervention strategy to prevent new HIV infections, but knowledge about FSWs' experiences of condom failure and PrEP use remains scarce. Therefore, this study explores FSWs' experiences co

ALTHOUGH MO YAN’S claim to fame is undoubtedly as the Nobel laureate from China, the 23 public lectures gathered in Mo Yan Speaks present a truly “glocal” writer who has one literary foot firmly planted in the soil of his native Gaomi Township and the other tiptoeing into the arena of world literature. They show an author performing a balancing act between his international elite status and the lo

We examine selection by class origin and gender in the emigration from Sweden to the United States during the age of mass migration. We use full-count census data linked to emigration lists to create a panel of over one million men and women. Class selection was similar for men and women, with children from medium-skilled backgrounds being most likely to leave. Selection on class origin was most p

Nakhlite meteorites are igneous rocks from Mars that were aqueously altered ~630 million years ago. Hydrothermal systems on Earth are known to provide microhabitats; knowledge of the extent and duration of these systems is crucial to establish whether they could sustain life elsewhere in the Solar System. Here, we explore the three-dimensional distribution of hydrous phases within the Miller Range

Purpose of Review: This article reviews controversial questions within the field of lung transplantation, with a focus on data generated within the last 3 years. We aim to summarize differing opinions on a selection of topics, including bridge-to-transplantation, intraoperative machine circulatory support, bronchial anastomosis, size mismatch, delayed chest closure, and ex vivo lung perfusion.Rece

We present a relativistic and model-independent method to derive structure-dependent electromagnetic finite-size effects. This is a systematic procedure, particularly well-suited for automation, which works at arbitrarily high orders in the large-volume expansion. Structure-dependent coefficients appear as zero-momentum derivatives of physical form factors which can be obtained through experimenta

Alzheimer's disease (AD) not only takes an emotional toll on the individual with the disease, their families, relatives, and caretakers, it also has immense socioeconomic consequences on the health care system and society. Moreover, the socioeconomic consequences are expected to increase significantly, thus reducing the social and economic cost of AD is of high importance. Recently, exposure to 40

We explore how team gender composition affects willingness to lead by randomly assigning participants in an experiment to male- or female-majority teams. Irrespective of team gender composition, men are substantially more willing than women to lead their team. The pooled sample, and women separately, are more willing to lead female- than male-majority teams. An analysis of mechanisms reveals that

Rationale: The management of indeterminate pulmonary nodules (IPNs) remains challenging, resulting in invasive procedures and delays in diagnosis and treatment. Strategies to decrease the rate of unnecessary invasive procedures and optimize surveillance regimens are needed. Objectives: To develop and validate a deep learning method to improve the management of IPNs. Methods:ALung Cancer Prediction

The aim of this paper was to analyse how three different television adaptations of Jane Austen’s Emma(1815) avail themselves of the medium of television to narrate the story. The productions analysed are John Glenister’s BBC series from 1972, dramatised by Denis Constanduros; Diarmuid Lawrence’s ITV film from 1996, dramatised by Andrew Davies; and Jim O’Hanlon’s BBC series from 2009, dramatised by

Some major challenges in the development of L2L products is the lack of efficient converter electronics, modelling tools for dimensioning and furthermore, characterization facilities to support the successful development of the products. We report the development of 2 Three-Port-Converters respectively for 1-10Wp and 10-50 Wp with a peak efficiency of 97% at 1.8 W of PV power for the 10 Wp version

BACKGROUND: Intraabdominal and retroperitoneal sarcomas (IaRS) are malignant connective tissue tumors. Surgical resection is often the only curative treatment. The primary objective was to report the mid-term outcomes following contemporary treatment protocols and identify prognostic factors.METHODS: A retrospective review of consecutive patients (n = 107) with IaRS treated at single center from 2

Avhandlingen närmar sig frågan om hur journalistiska praktiker underlättar konstruktionen av kändisstatus. Teoretiskt uppfattas kändisskap som en särskilt flytande form av social status baserat på medierad uppmärksamhet och engagemang. Journalistik studeras som en invitation att dela upplevelser, organiserade utifrån narrativa strukturer. De empiriska fallen som studeras i avhandlingen är två mångThe thesis approaches the research question of how journalistic practices facilitate the construction of celebrity status. Theoretically, celebrity is conceptualised as a particularly fluid form of social status based on mediatized attention and engagement. Journalism is studied as an invitation to shareexperiences, organised through media logics and narrative structures. The empirical cases studi

In-situ quantification of particle concentration during the combustion of solid fuel powders is of importance for analyzing their combustion behaviors. Digital holography (DH) is applied here for studying iron powder combustion at high concentration. The performance of DH as a function of particle concentration is thoroughly studied with synthetic holograms. The detection efficiency is found to be

Residues 136-159 of VPI of foot and mouth disease virus (FMDV) comprise the G-H loop of the protein and form a prominent feature on the surface of virus particles. This sequence contains an immunodominant neutralizing epitope, which can be mimicked with synthetic peptides, and includes an Arg, Gly, Asp motif which has been implicated in the binding of the virus to cellular receptors. Crystallograp

Negative trends of climate change and biodiversity loss are closely linked with farming practices, and it is therefore essential to re-think how agricultural systems can sequester more carbon, and simultaneously create vital ecosystems. The overall aim of this research is to imagine Swedish farms as carbon sinks rather than sources, and how to re-design the current farm- and food system to also ad