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Dosimetric Benefits From Deep Inspiration Proton and Photon Therapy for Hodgkin Lymphoma
Response of the FAst TIMing Array (FATIMA) for DESPEC at FAIR Phase-0
The Monte-Carlo simulated response for γ-ray detection of the FAst TIMing Array (FATIMA) for exploitation within the DEcay SPECtroscopy (DESPEC) experimental system at the FAIR Phase-0 facility at Darmstadt, Germany is presented. In this configuration, FATIMA consisted of 36 LaBr3(Ce) detectors surrounding the AIDA, position-sensitive charged-particle active stopper. The decay of the Iπ=8+ isomer-
Poly(arylene alkylene)s with Tetrazole Pendants for Alkaline Ion-Solvating Polymer Electrolyte
Alkaline ion-solvating membranes derived from a tetrazole functionalized poly(arylene alkylene) are prepared, characterized and evaluated as electrode separators in alkaline water electrolysis. The base polymer, poly[[1,1′-biphenyl]-4,4′-diyl(1,1,1-trifluoropropan-2-yl)], is synthesized by superacid catalyzed polyhydroxyalkylation and subsequently functionalized with tetrazole pendants. After equi
"Are my deserts no better?" : Aliens, Underdogs and Outsiders in The Merchant of Venice
Abstract in ArmenianԳրականագէտ Հարոլդ Պլում յայտնած է, թէ մարդ պէտք է ըլլայ «կոյր, խուլ եւ համր չհասկնալու համար, որ Շէյքսփիրի հոյակապ, երկդիմի Վենետիկի Վաճառականը… խորապէս հակասեմական գործ մըն է»։ Նման կարծիքներ ընդհանրացած են նաեւ ակադեմական աշխարհէն դուրս։ Օթելլոյի եւ Անսանձ Կնոջ Սանձահարումին հետ, Վենետիկի Վաճառականը անհանգստութեան մատնո
Geijer's Macbeth : Page, stage and the seeds of time
(There Is) Nothing Like a Dane : Gertrudes at Elsinore and Elsewhere
This article gives a brief account of the two-hundred-year-old performance history of Hamlet at Elsinore Castle; this is followed by a discussion of Gertrude as portrayed in nine English or English-speaking Hamlets at Elsinore, beginning with Olivier and the Old Vic in 1937 and concluding with Cape Town Theatre Company eighty-five years later, in 2022. The article discusses different aspects of ho
Preserving the past to serve the future : Lilli Zickerman’s inventory of textile handicrafts 1914–1931
Lilli Zickerman (1858–1949) was an entrepreneur who took part in organising the Swedish handicraft associations in the late 19th century. She was also a pioneer in the archives and active in the feminine sphere of textile handicraft. From 1914–1931 she conducted a huge inventory called Swedish Folk Textile Art that consists of more than 24,000 photographs and descriptions of vernacular textiles an
Immigrants and comics : graphic spaces of remembrance, transaction, and mimesis
Injury severity prediction of cyclist crashes using random forests and random parameters logit models
Cycling provides numerous benefits to individuals and to society but the burden of road traffic injuries and fatalities is disproportionately sustained by cyclists. Without awareness of the contributory factors of cyclist death and injury, the capability to implement context-specific and appropriate measures is severely limited. In this paper, we investigated the effects of the characteristics rel
Online dynamic flat-field correction for MHz microscopy data at European XFEL
The high pulse intensity and repetition rate of the European X-ray Free-Electron Laser (EuXFEL) provide superior temporal resolution compared with other X-ray sources. In combination with MHz X-ray microscopy techniques, it offers a unique opportunity to achieve superior contrast and spatial resolution in applications demanding high temporal resolution. In both live visualization and offline data
Resistance to anti-PD-1/anti-PD-L1 : galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1
BACKGROUND: Galectin-3 (Gal-3) is a β-galactoside-binding lectin that is highly expressed within the tumor microenvironment of aggressive cancers and has been suggested to predict a poor response to immune checkpoint therapy with the anti-PD-1 monoclonal antibody pembrolizumab. We aimed to assess if the effect of Gal-3 was a result of direct interaction with the immune checkpoint receptor.METHODS:
Strong Binding of C-Glycosylic1,2-Thiodisaccharides to Galectin-3─Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds
Galectin-3 is involved in multiple pathways of many diseases, including cancer, fibrosis, and diabetes, and it is a validated pharmaceutical target for the development of novel therapeutic agents to address unmet medical needs. Novel 1,2-thiodisaccharides with a C-glycosylic functionality were synthesized by the photoinitiated thiol-ene click reaction of O-peracylated 1-C-substituted glycals and 1
Generating GABAergic interneurons through reprogramming and differentiation strategies : English
In recent years reprogramming techniques, differentiation protocols, and sequencing analysis have opened a field for generating and studying human-derived neurons with greater potential than ever before. This has generated a large number of studies with the goal of deriving bona fide neurons. Both direct reprogramming and differentiation have benefits and drawbacks, while direct reprogramming can
Scandinavian Exceptionalisms : Culture, Society, Discourse
The Court’s Ruling in Volkswagen Italia: Revisiting the Principle of Ne Bis in Idem with a Pinch of Res Judicata
SCIT-treatment With a Chemically Modified, Aluminum Hydroxide Adsorbed Peanut Extract (HAL-MPE1) Was Generally Safe And Well Tolerated And Showed Immunological Changes In Peanut Allergic Patients
RationaleThere is no effective disease modifying treatment for peanut allergy available. A Phase I safety and tolerability study was performed with a chemically modified, Al(OH)3 adsorbed peanut extract (HAL-MPE1) for subcutaneous immunotherapy (SCIT).MethodsIn a randomized, double-blind, placebo controlled, single-centre, Phase I study, 17 Caucasian subjects with peanut allergy were randomized to
Effect of a single nanosecond pulsed discharge on a flat methane–air flame
Successful implementation of plasma-assisted combustion in applied thermal processes heavily relies on how the plasma can be formed as it interacts with the reactive flow and what the effects are of such a plasma on the combustion process. The current study is an experimental investigation of a plasma-assisted lifted flat methane–air flame by a nanosecond pulsed discharge at atmospheric pressure.
3D-tomographic reconstruction of gliding arc plasma
his study presents three-dimensional (3D) emission tomography on gliding arc discharge for volumetric measurements of plasma luminosity fields. The 3D tomography of the plasma luminosity field enables quantification and characterization of 3D plasma features, which are not easily accessible in two-dimensional measurements. Simultaneous projections of the plasma discharge were imaged using multiple
Combined solar and membrane drying technologies for sustainable fruit preservation in low-income countries – prototype development, modelling, and testing
This investigation consisted of developing and evaluating solar dryers together with semi-permeable membrane pouches for drying juicy fruits in low-income tropical countries. Two design iterations were carried out including prototype modelling and testing. The latest developed solar dryers were a passive and an active solar dryer. Modelling was initially carried out mathematically using an equatio