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BackgroundRight ventricular–pulmonary arterial (RV–PA) uncoupling is central to prognosis in precapillary pulmonary hypertension (PH). While the tricuspid annular plane systolic excursion tosystolic pulmonary artery pressure (TAPSE/sPAP) ratio is an established bedside surrogate of RV–PA coupling, novel energetic markers such as three-dimensional (3D)–derived right ventricular (RV) global wasted w
Context. The majority of Galactic globular star clusters (GCs) have been reported to contain at least two populations of stars (hereafter, we use P1 for the primordial and P2 for the chemically enriched population). Recent observational studies found that dynamically old GCs have P1 and P2 spatially mixed due to relaxation processes. However, in dynamically young GCs, where P2 is expected to be mo
Insulin resistance (IR) contributes to atherogenic dyslipidemia and elevated ASCVD risk. Apolipoprotein A1 (ApoA1)-associated lipoproteins have diverse anti-atherogenic functions, but it is unclear whether IR drives adverse changes in their proteomic composition. We hypothesized that IR is associated with an atherogenic ApoA1 proteome and that insulin-sensitizing interventions would improve its co
Acoustic forces occurring in resonant microfluidic chambers allow the handling of micrometer-sized particles. Trapping of nanoparticles has been shown for high particle concentrations and after preseeding the chamber with larger particles. We show that the trapping mechanism is due to synergy between hydrodynamic shielding and acoustic forces. Acoustic interactions are significant only when seed p
Atmospheric inverse modelling and ecosystem data assimilation are two complementary approaches to estimate CH4 emissions. The inverse approach infers emission estimates from observed atmospheric CH4 mixing ratio, which provide robust large scale constraints on total methane emissions, but with poor spatial and process resolution. On the other hand, in the ecosystem data assimilation approach, the
The striped p × √3 reconstruction of Au(111) is a textbook example of how electrode surfaces reorganise in response to an applied potential. Using in situ high-energy surface X-ray diffraction, we track the surface reconstruction in 0.1 M HClO4electrolyte while the potential is cycled at both 5 mV s−1and 2 mV s−1between 0.06 V and 0.86 V versus RHE. Reciprocal-space maps, collected every ∼10 s, sh
An approach to reducing greenhouse gas emissions that shows promise is the electrochemical conversion of CO2 to products with added value. Here, we present [Co(8HQ-Tpy)(H2O)]2 (PF6)2 ([Co1]), a cobalt-based molecular electrocatalyst that can convert CO2 to CO in a DMF/H2 O mixture (4.8 : 0.2 v/v) in a selective manner (8HQ-Tpy = 2-([2,2′:6′,2′′-terpyridin]-4′-yl)quinolin-8-ol). At an overpotential
This is the Replicated Computational Results (RCR) Report for the article ‘Stress Testing Control Loops in Cyber-Physical Systems’. The article proposes a novel approach for testing Cyber-Physical Systems (CPS) based on the integration of the guarantees that can be provided with the control theoretical models into the software testing practices. This RCR report describes how to reproduce the empir
AIM: We aimed to investigate if the incidence of type 1 diabetes increased in children during the SARS-CoV-2 pandemic and whether SARS-CoV-2 antibodies were more frequently present at diagnosis compared with healthy individuals. We also examined whether clinical characteristics and coexisting autoimmunity differed between SARS-CoV-2 antibody positive and negative individuals.METHODS: This retrospe
Photonic topological insulators and self-induced nonreciprocity based on nonlinear effects in asymmetric structures have garnered increased attention due to their potential applications in quantum information technologies and advanced photonic integrated circuits. In this study, we combine these two fields and present asymmetric photonic crystal designs based on all-dielectric checkerboard structu
BACKGROUND AND OBJECTIVE: The treatment landscape for metastatic hormone-sensitive prostate cancer (mHSPC) is evolving rapidly. Real-world data (RWD) are essential to understand actual treatment use and outcomes. This study aimed to describe treatment trajectories and clinical outcomes in a large, multicenter RWD cohort under the PIONEER project. METHODS: Eight European and US databases (2016-2020
Background: Low-cost particulate matter sensors have enabled new opportunities for exposure monitoring but require evaluation before application in epidemiological studies. This study assessed the performance of the SPS30 sensor integrated into the ARMIE portable monitoring sensor-node under controlled laboratory conditions. Methods: Sensors were co-located with two comparison instruments—the opti
BACKGROUND AND OBJECTIVE: A post hoc analysis of TITAN evaluated the clinical benefit of apalutamide plus androgen-deprivation therapy (ADT) versus ADT alone in metastatic hormone-sensitive prostate cancer (mHSPC) with high disease burden. METHODS: Patients were assessed in subgroups of those with four to fewer than ten, ten to <20, or ≥20 bone metastases; with lung but not liver metastases; and w
Non-round cell sarcomas may occur in children or young adolescents. We present some examples of the most common entities: epithelioid sarcoma, osteosarcoma; malignant peripheral nerve sheath tumor (MPNST), congenital infantile fibrosarcoma, and synovial sarcoma.
Diffraction gratings are among the most fundamental optical elements. They are essential in ultrafast optics for manipulating the spectral phase of coherent ultrashort light pulses in grating stretchers, compressors, and pulse shapers. In this work, we have exploited an effect associated with diffraction from a single grating, which can produce large amounts of spatially dependent GDD. Leveraging
Tropical forests are essential for global biodiversity, carbon storage, and hydrological regulation, yet accelerating land-use and land-cover change are rapidly eroding these functions across Southeast Asia. In Cambodia, forest conversion surrounding protected landscapes has intensified over recent decades, but its long-term ecological and economic consequences remain poorly quantified because few
