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Propagation of Tau Pathology : Integrating Insights From Postmortem and In Vivo Studies

Cellular accumulation of aggregated forms of the protein tau is a defining feature of so-called tauopathies such as Alzheimer's disease, progressive supranuclear palsy, and chronic traumatic encephalopathy. A growing body of literature suggests that conformational characteristics of tau filaments, along with regional vulnerability to tau pathology, account for the distinct histopathological morpho

Inter-laboratory study on standardized MPS libraries : evaluation of performance, concordance, and sensitivity using mixtures and degraded DNA

We present results from an inter-laboratory massively parallel sequencing (MPS) study in the framework of the SeqForSTRs project to evaluate forensically relevant parameters, such as performance, concordance, and sensitivity, using a standardized sequencing library including reference material, mixtures, and ancient DNA samples. The standardized library was prepared using the ForenSeq DNA Signatur

Cardiovascular changes in patients with mild-to-moderate chronic kidney disease compared with healthy subjects : a 5-year follow-up study

Background: There is limited knowledge about how cardiovascular parameters change over time in patients with mild-to-moderate chronic kidney disease (CKD). We studied several cardiovascular biomarkers over a 5-year period in patients with mild-to-moderate CKD and in healthy controls. Methods: Fifty-four patients with CKD stages 2–3 and 54 controls were included. The CKD patients were closely monit

Plasma ascorbic acid and the risk of islet autoimmunity and type 1 diabetes : the TEDDY study

Aims/hypothesis: We studied the association of plasma ascorbic acid with the risk of developing islet autoimmunity and type 1 diabetes and examined whether SNPs in vitamin C transport genes modify these associations. Furthermore, we aimed to determine whether the SNPs themselves are associated with the risk of islet autoimmunity or type 1 diabetes. Methods: We used a risk set sampled nested case–c

Outcomes After Surgery for Unilateral Dominant Primary Aldosteronism in Sweden

Background: Primary aldosteronism (PA) is the most common cause of secondary hypertension. Surgery is the mainstay of treatment for unilateral dominant PA, but reported cure rates varies. The aim of the present study was to investigate contemporary follow-up practices and cure rates after surgery for PA in Sweden. Methods: Patients operated for PA and registered in the Scandinavian Quality Registe

Synaptotagmin binding to botulinum neurotoxins

Botulinum neurotoxins (BoNTs) are exceptionally toxic proteins that cause paralysis, but are also extensively used as treatment for various medical conditions. Most BoNTs bind two receptors on neuronal cells, namely a ganglioside and a protein receptor. Differences in the sequence between the protein receptors from different species can impact the binding affinity and toxicity of the BoNTs. Here w

Maternal age and risk of cesarean section in women with induced labor at term—A Nordic register-based study

Introduction: Over the last decades, induction of labor has increased in many countries along with increasing maternal age. We assessed the effects of maternal age and labor induction on cesarean section at term among nulliparous and multiparous women without previous cesarean section. Material and methods: We performed a retrospective national registry-based study from Denmark, Finland, Iceland,

Ingemar Ståhl 1938-2014. A Portrait of a Political Economist in the Swedish Welfare State

For many decades, Ingemar Ståhl was a well-known economist in Sweden. He introduced new perspectives into research, teaching and public debate. He made his presence felt in areas as diverse as housing policy, defense economics, energy policy, financial economics, industrial policy, higher education, union controlled wage earner funds, law and economics, health-care economics and taxation. He advoc

In Pursuit of a Stable Stabilization Policy in Sweden. From the Gold Standard to Inflation Targeting and Beyond

In a historical perspective, the stabilization policy regime in Sweden is in a state of constant change, affected by economic crises, international impulses, domestic politics, and developments in macroeconomic theory. Economists have been deeply involved in this process. The current framework for monetary and fiscal policy, with an independent central bank focusing on inflation targeting, and a r