Leukotriene A(4) hydrolase (LTA4H) is a key enzyme in the inflammatory process of mammals. It is an epoxide hydrolase and an aminopeptidase of the M1 family of the MA clan of Zn-metallopeptidases. We have solved the crystal structure of LTA4H in complex with N-[3(R)-[(hydroxyamino)carbonyl]-2-benzyl-1-oxopropyl]-L-alanine, a potent inhibitor of several Zn-metalloenzymes, both endopeptidases and am

Popular Abstract in Swedish Diabetes är en snabbt växande folksjukdom som redan har drabbat 200 miljoner världen runt. Det finns två typer av sjukdomen: typ I samt typ II diabetes. Den förstnämnda drabbar vanligtvis de unga och beror på en s.k. autoimmun reaktion där kroppens egna immunförsvar av okänd anledning plötsligt inte känner igen insulincellerna och börjar attackera dem. Typ II diabetes uDiabetes affects around 200 million people worldwide. Curing diabetes would require the prevention of autoimmune destruction of beta cells and restoration of the beta cell mass restored either through regeneration or transplantation of the insulin producing cells. Islet transplantation according to the Edmonton protocol have been the most promising therapeutic option for Diabetes type I patients,

Most distributed optimization methods used for distributed model predictive control (DMPC) are gradient based. Gradient based optimization algorithms are known to have iterations of low complexity. However, the number of iterations needed to achieve satisfactory accuracy might be significant. This is not a desirable characteristic for distributed optimization in distributed model predictive contro

Objective. Postoperative fatigue syndrome (POFS) is a general and main complication after surgery. However, there is no stable and standardized animal model for POFS. The aim of the present study was to establish a rodent model of POFS by small intestinal resection, with POFS evaluated by acknowledged physical and behavioral methods. Material and Methods. Forty-two Sprague-Dawley rats were randoml

Objective To assess the use of lipid-lowering therapy in patients with known coronary heart disease (CHD), cerebrovascular disease or diabetes in a community-based population in Sweden considering expert recommendations. Methods A random sample of individuals aged >= 40 years who were surveyed in 1993-1994 were revisited 10 years later during 2003-2004 (n=724). A clinical investigation focused on

Identical neutral kaon pair correlations are measured in root s = 7 TeV pp collisions in the ALICE experiment. One-dimensional (KsKs0)-K-0 correlation functions in terms of the invariant momentum difference of kaon pairs are formed in two multiplicity and two transverse momentum ranges. The femtoscopic parameters for the radius and correlation strength of the kaon source are extracted. The fit inc

The Wnt signaling pathway is highly conserved and crucial during embryonic development. Aberrant Wnt signaling is important in several different disease processes. One such disease process is the development and progression of cancer. Malignant melanoma is a highly aggressive tumor type, in which Wnt signaling is essential. Once a melanoma tumor has spread and formed metastasis, there are few trea

Swedish Health and Medical Services act states that good care should be given to the entire population on equal terms. Still studies show that access to care in Sweden differ related to for example gender and socioeconomic variables. One of the areas in Swedish health care that has attracted attention for potential inequity in access is Cataract Extraction (CE). Previous studies of access to CE in

BACKGROUND: Cancer stem cells (CSCs) have been invoked in resistance, recurrence and metastasis of cancer. Consequently, curative cancer treatments may be contingent on CSC selective approaches. Of particular interest in this respect is the ionophore salinomycin, a natural product shown to be 100-fold more active against CSCs than clinically used paclitaxel. We have previously reported that synth

Background. Age-specific incidence rates for breast cancer in low-risk and high-risk ethnic populations differ by age at which the incidence maximum is reached: around 50 years in low-risk populations and over 60 years in high-risk populations. The interpretation of these differences remains unsettled, one line primarily referring to biological differences, the second one to cohort effects of rapi

Cerebral injury is a critical aspect of the management of patients in intensive care. Pathological conditions induced by cerebral ischemia, hypoxia, head trauma, and seizure activity can result in marked residual impairment of cerebral function. We have investigated the potential mechanisms leading to neuronal cell death in pathological conditions, with the aim of discovering therapeutic targets a

This paper explores the effects of anti-terrorism policy and legislation on the Muslim immigrant communities, in general, and British-born Muslims, in particular. R v Malik, in which the Court of Appeal quashed Samina Malik's conviction on terrorism charges, provides our point of entry into the legal discourse on counter-terrorism. Malik's conviction at the Old Bailey and the subsequent decision o

Nanowire plasmons can be launched by illumination at one terminus of the nanowire and emission can be detected at the other end of the wire. Using polarization dependent dark-held scattering spectroscopy, we measure how the polarization of the emitted light depends on the polarization of the incident light. We observe that the shape of the nanowire termination plays an important role in determinin

Precise regulation of β-cell function is crucial for maintaining blood glucose homeostasis. Pax6 is an essential regulator of β-cell-specific factors like insulin and Glut2. Studies in the developing eye suggest that Pax6 interacts with Mitf to regulate pigment cell differentiation. Here, we show that Mitf, like Pax6, is expressed in all pancreatic endocrine cells during mouse postnatal developmen