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Drug dissolution rate measurements - evaluation of the rotating disc method.

Dissolution rate measurements are important to understand the behaviour of drugs or drug formulations. Many methods for measuring dissolution rates are available and a good choice should be based on method limitations as well as drug characteristics. In the present study the rotating disc method was critically evaluated for dissolution rate measurements, using aspirin and benzoic acid as model sub

Dyslexic Students: Success Factors for Support in a Learning Environment

This study examines possible success factors when developing technical solutions for dyslexic students. Findings in the literature, in a web survey answered by students and in the experiences from the development process at the Medical Faculty Library, Lund University, were used to find out potential success factors and difficulties. The literature found describes what dyslexia is, the situation f

The role of integrin glycosylation in galectin-8-mediated trabecular meshwork cell adhesion and spreading

Primary open angle glaucoma (POAG) is a major blindness-causing disease, characterized by elevated intraocular pressure due to an insufficient outflow of aqueous humor. The trabecular meshwork (TM) lining the aqueous outflow pathway modulates the aqueous outflow facility. TM cell adhesion, cell-matrix interactions, and factors that influence Rho signaling in TM cells are thought to play a pivotal

Determinants of stress fracture risk in United States Military Academy cadets

Background: Prior studies have identified some risk factors for stress fracture in athletes and military recruits. Objective: To determine whether historical factors, physical measures, biochemical variables of skeletal metabolism, genetic factors, bone density (BMD) and bone size could predict risk of stress fracture over 4 years in physically fit cadets at the US Military Academy (USMA). Methods

Multiple Andreev reflections in hybrid multiterminal junctions

We investigate theoretically charge transport in hybrid multiterminal junctions with superconducting leads kept at different voltages. It is found that multiple Andreev reflections involving several superconducting leads give rise to rich subharmonic gap structures in the current-voltage characteristics. The structures are evidenced numerically in junctions in the incoherent regime.

Evidence for Cardiomyocyte Renewal in Humans

It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turnin

Wind power or uranium mine: Appraisal of two energy-related environmental changes in a local context

This study explores factors associated with the individual's appraisal of anticipated environmental changes caused by energy production facilities. The study took place in a Swedish village where exploratory drilling, that could eventually lead to a uranium mine, was being conducted at the same time as a wind farm was approved. Results from the survey, which included the total population, were int

Bacterial and fungal growth in soil heated at different temperatures to simulate a range of fire intensities

The intensity of a fire is an important factor determining the recovery of soil microorganisms after a forest fire, since it can alter the quality and quantity of carbon sources. Recovery of the microbial community was studied in a Mediterranean pine forest soil subjected to different temperatures to simulate the short-term effects of fire intensity on bacterial and fungal growth, estimated using

Molecular subtypes in ductal carcinoma in situ of the breast and their relation to prognosis: a population-based cohort study

Background: Different molecular subtypes of breast cancer have been identified based on gene expression profiling. Treatment suggestions based on an approximation of these subtypes by immunohistochemical criteria have been published by the St Gallen international expert consensus panel. Ductal carcinoma in situ (DCIS) can be classified into the same molecular subtypes. Our aim was to study the rel

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

Genome-wide association studies have recently identified at least 15 susceptibility loci for systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from 2,466 regions that showed nominal evidence of association to SLE (P < 0.05) in a genome-wide study and genotyped them in an independent sample of 1,963 cases and 4,329 controls. This replication effort identified fiv

Utility Disturbance Management in the Process Industry

Use of utilities, such as steam and cooling water, is very common at industrial sites. Utilities are often shared between several production areas, and a disturbance in the supply of a utility is therefore likely to affect a large part of the production site, and cause great loss of revenue. In order to minimize the loss of revenue due to disturbances in utilities, the optimal supply of utilities

Lighting Control Systems for Energy Saving and User Acceptance: State-of-the-art and future directions

Popular Abstract in Swedish Belysning står för en femtedel av den globala elanvändningen. I Sverige motsvarar efterfrågan på energi för belysning i kontorsbyggnader 20% av den totala elanvändningen. Utbyte av gamla belysningsanläggningar anses vara bland de mest kostnadseffektiva sätten att minska energianvändningen i byggnader. I synnerhet utlovar användningen av avancerade ljusstyrningssystem enLighting accounts for one-fifth of global electricity use. In Sweden, energy demand for lighting corresponds to 20% of the total electricity use in office buildings. Lighting retrofit measures are considered to be among the most cost-efficient way to reduce energy use in buildings. In particular, the use of advanced lighting control systems promises energy savings of between 2 and 60%, but system

Analysis of multiple scattering suppression using structured laser illumination planar imaging in scattering and fluorescing media

The accuracy, precision and limitations of the imaging technique named Structured Laser Illumination Planar Imaging (SLIPI) have been investigated. SLIPI, which allows multiply scattered light to be diminished, has previously demonstrated improvements in image quality and contrast for spray imaging. In the current study the method is applied to a controlled confined environment consisting of a mix

Barbour's Typologies and the Contemporary Debate on Islam and Science

Despite various criticisms, Ian Barbour's fourfold classification of the possible relationships between religion and science remains influential. I compare Barbour's taxonomy with the theories of four authors who, in the last four decades, have addressed the relationship between science and religion from a Muslim perspective. The aim of my analysis is twofold. First, I offer a comparative perspect

The cynicism of consumer morality

Based on an empirical analysis of a yearlong netnography of a Swedish online fashion community, and the explication of the concept of modern cynicism, this paper develops a novel perspective on consumer morality. The analysis suggests that modern cynicism informs consumers of the reasonableness in consciously stating one type of morality while acting out another, in order to handle the morally con

Photoelectrocatalytic Oxidation of NADH at a Graphite Electrode Modified with a New Polymeric Phenothiazine

A new approach for photoelectrocatalytic oxidation of NADH is described, based on a graphite electrode (G) modified with a new phenothiazine derivative, polyphenothiazine formaldehyde (PPF). Electrochemical measurements reveal that G/PPF presents a quasireversible voltammetric response, corresponding to a 2e(-)/2H(+) transfer and that G/PPF modified electrodes show electrocatalytic activity for NA

Global Human Rights Awareness, Education and Democratization

The 1990s was the era of human rights awareness, democratic transitions, and growing involvement of international organizations and the nongovernmental sector in human rights education (HRE). The UN Decade for HRE from 1995-2004 was not only born out of the initiatives and pressures of nongovernmental organizations (NGOs) but it also actively triggered many new private initiatives and commitments