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Immune Cell-Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation

Infiltration of human melanomas with cytotoxic immune cells correlates with spontaneous type I IFN activation and a favorable prognosis. Therapeutic blockade of immune-inhibitory receptors in patients with preexisting lymphocytic infiltrates prolongs survival, but new complementary strategies are needed to activate cellular antitumor immunity in immune cell-poor melanomas. Here, we show that prima

PIM1 kinase is destabilized by ribosomal stress causing inhibition of cell cycle progression

PIM1 is a constitutively active serine/threonine kinase regulated by cytokines, growth factors and hormones. It has been implicated in the control of cell cycle progression and apoptosis and its overexpression has been associated with various kinds of lymphoid and hematopoietic malignancies. The activity of PIM1 is dependent on the phosphorylation of several targets involved in transcription, cell

Search for high-mass diboson resonances with boson-tagged jets in proton-proton collisions at root s = TeV with the ATLAS detector

A search is performed for narrow resonances decaying into WW, WZ, or ZZ boson pairs using 20.3 fb(-1) of proton-proton collision data at a centre-of-mass energy of root s = TeV recorded with the ATLAS detector at the Large Hadron Collider. Diboson resonances with masses in the range from 1.3 to 3.0 TeV are sought after using the invariant mass distribution of dijets where both jets are tagged as a

Valence photoelectron spectroscopy of N-2 and CO: Recoil-induced rotational excitation, relative intensities, and atomic orbital composition of molecular orbitals

Recoil-induced rotational excitation accompanying photoionization has been measured for the X, A, and B states of N-2(+) and CO+ over a range of photon energies from 60 to 900 eV. The mean recoil excitation increases linearly with the kinetic energy of the photoelectron, with slopes ranging from 0.73 x 10(-5) to 1.40 x 10(-5). These slopes are generally (but not completely) in accord with a simple

q-space trajectory imaging for multidimensional diffusion MRI of the human brain.

This work describes a new diffusion MR framework for imaging and modeling of microstructure that we call q-space trajectory imaging (QTI). The QTI framework consists of two parts: encoding and modeling. First we propose q-space trajectory encoding, which uses time-varying gradients to probe a trajectory in q-space, in contrast to traditional pulsed field gradient sequences that attempt to probe a

Impact of Atomic Oxygen on the Structure of Graphene Formed on Ir(111) and Pt(111)

The effect of atomic oxygen adsorption on the structure and electronic properties of monolayer graphite (MG or graphene) grown on Pt(111) and Ir(111) has been studied using X-ray photoelectron spectroscopy, near-edge X-ray absorption fine structure spectroscopy, and scanning tunneling microscopy. For comparison, the adsorption of atomic oxygen on highly oriented pyrolytic graphite has been studied

A single inlet two-stage acoustophoresis chip enabling tumor cell enrichment from white blood cells

Metastatic disease is responsible for most cancer deaths, and hematogenous spread through circulating tumor cells (CTC) is a prerequisite for tumor dissemination. CTCs may undergo epithelial–mesenchymal transition where many epithelial cell characteristics are lost. Therefore, CTC isolation systems relying on epithelial cell markers are at risk of losing important subpopulations of cells. Here, a

The Jurassic-Cretaceous transition of the Fararp-1 core, southern Sweden: Sedimentological and phytological indications of climate change

The 116m deep Fararp-1 core drilled in the Vomb Trough in southernmost Sweden is dated by integrated terrestrial and marine palynostratigraphy. The lower part of the succession (ca 84 m) encompasses uppermost Jurassic to lowermost Cretaceous (uppermost Tithonian to Valanginian) strata. An unconformity separates the Valanginian strata from an overlying ca 1 m thick interval of upper Albian to Cenom

Development of Curative Therapies for Ewing Sarcomas by Interdisciplinary Cooperative Groups in Europe.

Curative therapies for Ewing sarcoma have been developed within cooperative groups. Consecutive clinical trials have systematically assessed the impact and timing of local therapy and the activity of cytotoxic drugs and their combinations. They have led to an increase of long-term disease-free survival to around 70% in patients with localized disease. Translational research in ES remains an area i

A numerical and experimental study of Polycyclic Aromatic Hydrocarbons in a laminar diffusion flame

During the process of biomass gasification tars are formed which exit the gasifier in vapor phase. Tar condensation creates problems like fouling and plugging of after-treatment, conversion and end-use equipment. Gasification tars consist mainly of Polycyclic Aromatic Hydrocarbons (PAHs). Former research has shown the possibilities and difficulties of tar conversion by partial combustion. Basic st

Distinct gene expression profiles in ovarian cancer linked to Lynch syndrome.

Ovarian cancer linked to Lynch syndrome represents a rare subset that typically presents at young age as early-stage tumors with an overrepresentation of endometrioid and clear cell histologies. We investigated the molecular profiles of Lynch syndrome-associated and sporadic ovarian cancer with the aim to identify key discriminators and central tumorigenic mechanisms in hereditary ovarian cancer.

Morphology and composition controlled GaxIn1-xSb nanowires: understanding ternary antimonide growth.

Antimonide-based nanowires represent an important new class of material with great promise for both fundamental physics studies and various device applications. We report a comprehensive study on understanding the growth behaviour of GaxIn1-xSb nanowires on GaAs substrates using Au nanoparticles. First, the effect of growth parameters on the morphology and composition of GaxIn1-xSb nanowires is ex

Arguments for a narrow species concept in Rubus sect. Corylifolii

A detailed inventory of Rubus sect. Corylifolii from the province of Halland in southwestern Sweden has been performed and the chromosome number of all distinct taxa and deviating morphotypes has been determined using flow cytometry. Once putative hybrids between Corylifolii and R. caesius or R. idaeus are recognized, essentially all stands of Corylifolii in Halland can be satisfactorily identifie

Ecosystem services: a useful concept for soil policy making!

This paper is based on the session ‘Ecosystem services: a useful concept for soil policy making?’ at the Wageningen Applied Soil Conference in September 2011. In that session it was shown from different angles that policy awareness of the dependence of humankind on ecosystem services has resulted in the development of tools for optimal allocation and quantification of ecosystem services and raisin

The C*-algebra of an affine map on the 3-torus

We study the C*-algebra of an affine map on a compact abelian group and give necessary and sufficient conditions for strong transitivity when the group is a torus. The structure of the C*-algebra is completely determined for all strongly transitive affine maps on a torus of dimension one, two or three.