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Background: Tau pathology correlates with and predicts clinical decline in Alzheimer's disease. Approved tau-targeted therapies are not available. Methods: ADAMANT, a 24-month randomised, placebo-controlled, parallel-group, double-blinded, multicenter, Phase 2 clinical trial (EudraCT2015-000630-30, NCT02579252) enrolled 196 participants with Alzheimer's disease; 119 are included in this post-hoc s

The aim was to investigate associations between marital status and mortality with a prospective cohort study design. A public health survey including adults aged 18–80 was conducted with a postal questionnaire in southern Sweden in 2008 (54.1% participation). The survey formed a baseline that was linked to 8.3-year follow-up all-cause, cardiovascular (CVD), cancer and other cause mortality. The pr

The remote forcing from land surface changes in the Sahara is hypothesized to play a pivotal role in modulating the intensity of the East Asian summer monsoon (EASM) through ocean-atmospheric teleconnections. This modulation has far-reaching consequences, particularly in facilitating societal shifts documented in northern China. Here, we present a well-dated lake-level record from the Daihai Lake

In this article, we present the first demonstration of the FengYun-3E (FY3E) Global Navigation Satellite System Occultation Sounder II-Reflectometry (GNOS-R) payload's capacity to detect near-surface soil freeze/thaw (F/T) states. This study offers an initial analysis of the F/T retrieval algorithm applied to data collected from the Arctic Circle, underscoring the GNOS-R's potential to deliver lon

This workshop considered whether there was a need for a fourth way (or ways) to organise and regulate public transport to complement the three existing models of classic regulation, deregulation and limited competition (including competition for the market). This was particularly viewed from the perspective of what constitutes a good (public) transport authority. The evidence was based on five sou

Objective: To systematically evaluate the ability of the CINA® LVO software to detect large vessel occlusions eligible for mechanical thrombectomy on CTA using conventional neuroradiological assessment as gold standard. Methods: Retrospectively, two hundred consecutive patients referred for a brain CTA and two hundred patients that had been subject for endovascular thrombectomy, with an accessible

In fifth generation district heating and cooling (5GDHC), the temperature range of the heat source is wider then in current common heat pump systems. The results of this study show that the heat pumps and chillers that are available in the market are not well adapted to 5GDHC applications due to the wide working range of 5GHDC. In order to maintain a high efficiency, current design parameters shou

In the Western world of today, the swastika is practically exclusively associated with Nazism, but in reality it is an ancient religious symbol, used in a number of different cults, symbolizing different deities. The oldest finds so far have been made in Ukraine and are between twelve and fifteen thousand years old. About seven thousand years ago the symbol existed in present-day Iran and five tho

The key message is the importance of a systemic approach to handling water and energy together, both in design and in oper-ation. The paper demonstrates how renewable energy, solar photovoltaic (PV) and solar thermal, in combination with a small nutrient removal plant, provides a reliable solution for small-scale decentralized water recovery operations. The system is automated and can operate outs

Mostly known for his letters, written in an impressionistic style, Johan Ekeblad was a nobleman and diplomat during the period of the Swedish Empire (svenska stormakts-tiden) in the seventeenth century. This article seeks to treat Ekeblad and his writing as an example of a baroque mentality—here de+ned as marked by dialectical relation-ships of old and new, order and disorder, the religious and th

Background: P-wave indices reflect atrial abnormalities contributing to atrial fibrillation (AF). We aimed to assess a comprehensive set of P-wave characteristics for prediction of incident AF in a population-based setting. Methods: Malmö Preventative Project (MPP) participants were reexamined in 2002–2006 with electrocardiographic (ECG) and echocardiographic examinations and followed for 5 years.

Despite concerns over its sustainability, space tourism is an emerging luxury consumer service which is promoted to participants as providing a new connection to Earth and humanity. However, little research examines the potential connectivity between sustainability and space tourism, especially given the strong technological dimensions of space tourism. The purpose of this study is to explore an e