Gene transfer is a promising drug delivery method of advanced therapeutic entities for Parkinson's disease. One advantage over conventional therapies, such as peripheral delivery of the dopamine pre-cursor L-DOPA, is site-specific expression of proteins with regenerative, disease-modifying and potentially neuroprotective capacity. Several clinical trials have been performed to test the capacity of

Photosystem I (PSI) is combined with Desulfovibrio gigas hydrogenase for the bioelectrocatalytic photosynthesis of hydrogen at an electrode surface. The activity of these two biocatalysts is linked by two redox polymers; a redox polymer with a relatively positive potential (loaded with an Os complex) is able to reduce PSI and thus facilitates the production of photoexcited electrons, whereas redox

Aeolian–coastal sediments and landforms are excellent palaeoenvironmental archives, but chronological studies of coastal records are scarce in Sweden. In this study, we provide luminescence and radiocarbon ages of aeolian activity and coastal landscape evolution on the Kristianstad plain, SE Sweden, based on the investigations of two foredunes and two inland dunes at Åhus and Vittskövle. Additiona

We consider the problem of designing distinguishers and nonrandomness detectors for stream ciphers using the maximum degree monomial test. We construct an improved algorithm to determine the subset of key and IV-bits used in the test. The algorithm is generic, and can be applied to any stream cipher. In addition to this, the algorithm is highly tweakable, and can be adapted depending on the desire

Artikeln diskuterar hur den nordiska språkgemenskapen påverkas av nutidasamhällsutveckling och framför allt av ny teknik. Denna påverkar våra språkmöten både på modersmålet och i det nordiska sammanhanget. Artikeln fokuserar på hur förändringarna påverkar våra språkmöten (i tal), och jag driver tesen att den nya tekniken på många punkter innebär tätare språkmöten med personer som vi redan känner o

Following an adverse event in a Swedish university hospital in 2010, three separate investigations seeking causal factors were conducted. We here review each of the analyses to see whether they together generate the kind of epistemological pluralism that could contribute to a systemic understanding of, and learning from, the event. Our content analysis shows that, while using vastly different amou

This study deals with the diffusion of a new medical technology — vaccination against smallpox — in nineteenth-century Scania in Sweden. Using an aggregated sample of parishes as well as a micro-level dataset for four parishes, we investigate the socioeconomic as well as the geographical patterns of diffusion of vaccination in the province. We also relate the adoption of vaccination across geograp

Obesity and its associated comorbidities (for example, diabetes mellitus and hepatic steatosis) contribute to approximately 2.5 million deaths annually and are among the most prevalent and challenging conditions confronting the medical profession. Neurotensin (NT; also known as NTS), a 13-amino-acid peptide predominantly localized in specialized enteroendocrine cells of the small intestine and rel

Background. To inform their health decisions, patients may seek narratives describing other patients' evaluations of their treatment experiences. Narratives can provide anti-treatment or pro-treatment evaluative meaning that low-numerate patients may especially struggle to derive from statistical information. Here, we examined whether anti-vaccine (v. pro-vaccine) narratives had relatively stronge

Identifying the molecular basis of environmentally induced phenotypic variation presents exciting opportunities for furthering our understanding of how ecological processes and the environment can shape the phenotype. Urban and rural environments present free-living organisms with different challenges and opportunities, which have marked consequences for the phenotype, yet little is known about re