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Determining universal processes related to best outcome in emergency abdominal surgery: a multicentre, international, prospective cohort study.

Emergency abdominal surgery outcomes represent an internationally important marker of healthcare quality and capacity. In this study, a novel approach to investigating global surgical outcomes is proposed, involving collaborative methodology using 'snapshot' clinical data collection over a 2-week period. The primary aim is to identify internationally relevant, modifiable surgical practices (in ter

Measurement of pion, kaon and proton production in proton-proton collisions at [Formula: see text] TeV.

The measurement of primary [Formula: see text], [Formula: see text], [Formula: see text] and [Formula: see text] production at mid-rapidity ([Formula: see text] 0.5) in proton-proton collisions at [Formula: see text][Formula: see text] 7 TeV performed with a large ion collider experiment at the large hadron collider (LHC) is reported. Particle identification is performed using the specific ionisat

Endoplasmic reticulum function in dendrites and dendritic spines of hippocampal neurons

Popular Abstract in Swedish Till och med kroppens allra enklaste celler är så avancerade att vi inte förstår i detalj hur de fungerar eller hur de påverkar kroppen. Nervceller tillhör kroppens mer avancerade celler och vi får erkänna att all den kunskap vi har om dem är mindre än vad som finns att veta. Komplexiteten hos hjärnan är mångfalt större för nervcellerna kommunicerar blixtsnabbt med varaIn the hippocampus, dendritic spines are compartmentalized postsynaptic micro-domains in the excitatory synapse. Subsets of bigger and mushroom-shaped hippocampal dendritic spines contain tubules and cisterns of endoplasmic reticulum (ER) that are connected to the soma and dendrites of the neuron. These ER containing spines differ in their ability to retain ER. We hypothesized a functional couplin

Is There Really Something Which Might Be Called a 'Self-Demonstrating Picture' : Even Within Scientific Imagery? Some Observations on a Double Illusion of Communication

I will propose some ideas about such pictures claiming to be self-demonstrating or selfillustrating, mostly using some classical anatomy illustrations. Based on these you may say that the anatomy seems to create a remarkable, realistic pictorial code, which casts together in one single, selfdemonstrating shape, an object of knowledge with the properties of the natural object itself. This is the pa

From Speed Profile Data to Analysis of Behaviour

Classification of speed profiles is necessary to allow interpretation of automatic speed measurements in terms of road user behaviour. Aggregation without considering variation in individual profile shapes easily leads to aggregation bias, while classification based on exogenous criteria runs the risk of loosing important information on behavioural (co-) variation. In this paper we test how three

Soil moisture variations affect short-term plant-microbial competition for ammonium, glycine, and glutamate.

We tested whether the presence of plant roots would impair the uptake of ammonium ([Formula: see text]), glycine, and glutamate by microorganisms in a deciduous forest soil exposed to constant or variable moisture in a short-term (24-h) experiment. The uptake of (15)NH4 and dual labeled amino acids by the grass Festuca gigantea L. and soil microorganisms was determined in planted and unplanted soi

Human native lipoprotein-induced de novo DNA methylation is associated with repression of inflammatory genes in THP-1 macrophages

Background: We previously showed that a VLDL-and LDL-rich mix of human native lipoproteins induces a set of repressive epigenetic marks, i. e. de novo DNA methylation, histone 4 hypoacetylation and histone 4 lysine 20 (H4K20) hypermethylation in THP-1 macrophages. Here, we: 1) ask what gene expression changes accompany these epigenetic responses; 2) test the involvement of candidate factors mediat

Flood analysis using generalized logistic models in partial duration series

Abstract in Undetermined As a generalization of the commonly assumed Poisson distribution (PD) used to estimate the annual number of peaks over threshold in partial duration series (PDS) model, the negative binomial (NB) distribution is proposed in this study. Instead of generalized pareto distribution (GPD) and exponential distribution (ED) models popularly applied to predict the probability of t

Similarities and differences in the characteristics and primary treatment of breast cancer in men and women - a population based study (Sweden)

Purpose. Male breast cancer (MBC) is an uncommon disease. In the absence of randomized studies, current guidelines are mainly based on data on the management of female breast cancer (FBC). In light of concerns regarding the quality and extent of management in men, the aim of the present study was to investigate whether there are differences in tumor characteristics, treatment and outcome in male c

Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study

Background: Epidemiologic data and animal models suggest that, despite the predominant role of human papillomavirus infection, sex steroid hormones are also involved in the etiology of invasive cervical carcinoma (ICC). Methods: Ninety-nine ICC cases, 121 cervical intraepithelial neoplasia grade 3 (CIN3) cases and 2 control women matched with each case for center, age, menopausal status and blood

The impact of information on landowners' participation in voluntary conservation programs - Theoretical considerations and empirical evidence from an agri-environment program in Saxony, Germany

The voluntary nature of programs that pay landowners for conservation measures raises the question of what factors favor participation in such programs. This article focuses on the controversial issue of the impact of information on the participation decision. We develop a straightforward model to analyze how information affects this decision, and empirically estimate the impact of information, as

Obituary: Prof. Dr. Hemming Virgin

Hemming Ivar Virgin (1918-2005) was a pioneer in plant photobiology.The main topics of his research covered areas such as light effects on viscosity of protoplasm, determination of turgor and elasticity of plant organs, chlorophyll formation and accumulation, plastid development during greening, and phytochrome regulation of physiological processes.

Institutional Conditions and Innovation Systems: On the Impact of Regional Policy on Firms in Different Sectors.

Moodysson J. and Zukauskaite E. Institutional conditions and innovation systems: on the impact of regional policy on firms in different sectors, Regional Studies. This paper deals with institutional conditions in regional innovation systems: how institutions affect the organization of innovation activities among firms; and in what ways regional policy initiatives can be supportive. The analysis dr

Determinants of serum levels of vitamin D: a study of life-style, menopausal status, dietary intake, serum calcium, and PTH

Background: Low blood levels of vitamin D (25-hydroxy D3, 25OHD3) in women have been associated with an increased risk of several diseases. A large part of the population may have suboptimal 25OHD3 levels but high-risk groups are not well known. The aim of the present study was to identify determinants for serum levels of 25OHD3 in women, i.e. factors such as lifestyle, menopausal status, diet and

Dietary flavonoid and lignan intake and breast cancer risk according to menopause and hormone receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Evidence on the association between dietary flavonoids and lignans and breast cancer (BC) risk is inconclusive, with the possible exception of isoflavones in Asian countries. Therefore, we investigated prospectively dietary total and subclasses of flavonoid and lignan intake and BC risk according to menopause and hormonal receptor status in the European Prospective Investigation into Cancer and Nu

MIMO Applications for Interference Mitigation in Multiple High Altitude Platform WCDMA Systems

In this paper we investigate the possibility of multiple HAP coverage of a common cell area. In particular we study the uplink system performance since it is considered as a worst case scenario. In order to obtain further enhancement (interference mitigation) we also apply space-time diversity techniques, such as Single-Input Multiple-Output (SIMO) receive diversity or Multiple-Input Multiple-Outp

Product formation controlled by substrate dynamics in leukotriene A4 hydrolase.

Leukotriene A4 hydrolase/aminopeptidase (LTA4H) (EC 3.3.2.6) is a bifunctional zinc metalloenzyme with both an epoxide hydrolase and an aminopeptidase activity. LTA4H from the African claw toad, Xenopus laevis (xlLTA4H) has been shown to, unlike the human enzyme, convert LTA4 to two enzymatic metabolites, LTB4 and another biologically active product Δ(6)-trans-Δ(8)-cis-LTB4 (5(S),12R-dihydroxy-6,1

Nature of the bias-dependent symmetry reduction of iron phthalocyanine on Cu(111)

Subtle changes in the geometric and electronic properties of supported molecules, with a potential impact on the functioning of molecular devices, can typically be imaged by scanning probe microscopy, but their exact origin and nature often remain unclear. Here we show explicitly that the symmetry reduction of iron phthalocyanine upon adsorption on Cu(111) can be observed not only in scanning tunn