Ligand-induced activation of the beta-receptor for platelet-derived growth factor (PDGF) induces tyrosine phosphorylation of a number of downstream signaling proteins. In the present study, we used two-dimensional gel electrophoresis to characterize the spectrum of proteins phosphorylated in response to PDGF stimulation in porcine aortic endothelial cells expressing PDGF beta-receptors. Several pr

Denna rapport härstammar från en kollegiegranskning i äldreomsorgen. Tio biståndshandläggare har undersökt sin verksamhet såsom den ter sig i en annan kommun inte så långt därifrån. De skriver kunnigt och engagerat om biståndsbedömning och ställer frågor kring hur detta arbete bör bedrivas. Bengt Ingvad och Christer Neleryd har sammanställt granskningarna. I ett inledande och avslutande kapitel ko

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We describe a new method for analysis of change in glaucomatous visual fields with the object to differentiate between changes caused by glaucoma from those caused by cataract, New pattern deviation change probability maps were developed from a prospectively collected glaucoma material and designed to be sensitive to changes in localized field loss, but to be unaffected by media-induced perimetric

Background/Objectives:To examine associations between food patterns, constructed with cluster analysis, and colorectal cancer incidence within the National Institutes of Health-AARP Diet and Health Study.Subjects/Methods:A prospective cohort, aged 50-71 years at baseline in 1995-1996, followed until the end of 2000. Food patterns were constructed, separately in men (n=293 576) and women (n=198 730

Increased incidence of prostate cancer has been reported in men exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD acts through the aryl hydrocarbon receptor (AhR), which interacts with the androgen receptor (AR). The AR gene contains a polymorphic CAG repeat that influences its transcriptional activity. We investigated the influence of TCDD on prostate cancer cells (PC-3) and non-tumor p

Objective. To examine psychiatric patients' experience of mechanical restraints and to describe the care the patients received. Background. All around the world, threats and violence perpetrated by patients in psychiatric emergency inpatient units are quite common and are a prevalent factor concerning the application of mechanical restraints, although psychiatric patients' experiences of mechanica

Cyclic nucleotide phosphodiesterases (PDEs) are important regulators of signal transduction processes mediated by cAMP and cGMP. One PDE family member, PDE3B, plays an important role in the regulation of a variety of metabolic processes such as lipolysis and insulin secretion. In this study, the cellular localization and the role of PDE3B in the regulation of triglyceride, cholesterol and glucose

The paper deals with the Cauchy problem for the linear constant-coefficient strongly hyperbolic system $u_t+Au_x=({1}/{delta})B$. The critical case where $B$ has a nontrivial nullspace is investigated. Under suitable assumptions on the matrices $A$ and $B$ the convergence in $L_2$ as $delta o 0$ of the solution $u(·,t,delta)$ of the Cauchy problem is proved. Then the evolution of the limit funct

Air quality standards are set to protect public health. The values of the standards are often based on health effect studies, without any statistical considerations. In order to judge if a standard is met measurements of ambient air quality are taken at monitoring stations, and these measured values are used to decide whether or not the standard has been violated. In this paper we examine the stat

Popular Abstract in Swedish De flesta av Sveriges cirka 15000 större broar är byggda i betong. Ett problem som kan uppkomma i betongbroar är sprickor, vilka kan bidra till att minska broarnas beständighet och säkerhet. I en del broar har fler sprickor uppkommit på sydsidan än på nordsidan vilket antyder att solen har stor påverkan på dessa broar, eftersom det är den enda faktor som skiljer sig väsWhen the temperature changes in the environment the temperature will also change in a structure. Complex interactions of climate factors affect the temperature changes. When the temperature is varied in a material it will expand or contract, and movements will be produced. If the movements are prevented, stresses may be induced which can contribute to cracks in the structure. Severe cracks have be