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Formulating Research Problems addresses one of the most critical yet often overlooked aspects of research: how to define and frame the problem at the heart of a study. While most research methods texts devote only a few pages to this question, Johan Alvehus offers a dedicated, accessible, and practical guide that helps students move beyond vague topics toward the development of clear, rigorous, an
Challengers struggle against more powerful elites and authorities to resolve environmental problems driven by social forces, but can sustainability research contribute to such collective action while remaining scientific? After five years of movement-relevant sustainability research using Burawoy’s extended case method, I seek to make three contributions. Empirically, I present strategic alliances
Background: Win statistics offer an alternative approach to clinical trials that use survival analysis to analyze composite endpoints. Our objective was to re-analyze data from previously published registry-based randomized controlled trials that produced hazard ratios using win statistics to evaluate the correspondence between them. Good correspondence was defined as both results being positive,
Hummeln is a simple impact structure located in south-eastern Sweden. It is approximately 1.2 km in diameter and almost completely covered by a lake. Here, we present the first detailed investigation of impactites and mapping of the 164.25 m deep drill core Hummeln-1 with a focus on impact metamorphism and the impact process. We find that the drilling has penetrated a complex sedimentary successio
The dominant narrative on equity, diversity, and inclusion in U.S. medical research emphasises the underrepresentation of Black and Hispanic participants in clinical trials, largely based on therapeutic phase 2 and 3 trials. Far less attention has been paid to phase 1 trials—particularly those involving healthy volunteers who assume health risks without therapeutic benefit, often for money. Focusi
Glycobiology has undergone a profound conceptual transformation from a largely descriptive discipline to a central framework for understanding biological regulation in health and disease [...].
Polycyclic aromatic hydrocarbons (PAHs) of molecular mass (MM) 302 Da comprise numerous structural isomers that are of high concern for human health. Because of their multiplicity, low abundance in the environment, and limited availability of authentic standards, their occurrence, composition, and environmental health risk remain not well characterized. Here we extend the characterization of MM 30
Wetlands are often constructed to counteract eutrophication or brownification of downstream waters, although our understanding of their differences in efficiency and effects is still scarce. Therefore, we here used the upper and lower 95% confidence limits of the average retention capacity of 11 wetlands to represent efficient and inefficient wetlands, respectively. We then modelled future scenari
A random planar quadrangulation process is introduced as an approximation for certain cellular automata in terms of random growth of lines, called rays, from a given set of points. This model turns out to be a particular (rectangular) case of the well-known Gilbert tessellation, which originally models the growth of needle-shaped crystals from the initial random points with a Poisson distribution
Retrospective, propensity-score-adjusted (PSA) studies have indicated to practitioners in the field that contrast-induced acute kidney injury (AKI) after contrast-enhanced CT (CECT) is of minor importance or even non-existent. This has led to controversies between clinicians demanding CECT not to miss any diagnoses and radiologists reluctant or even refusing CECT in risky patients. A critical revi
Process-based biosphere models, which formulate biophysical ecosystem processes, provide a mechanistic framework for understanding terrestrial carbon dynamics. In contrast, data-driven approaches, e.g., upscaling eddy covariance (EC) fluxes using satellite observations and machine learning, offer empirical estimates. These complementary methods often diverge significantly, particularly in estimati
SREBP transcription factors are key regulators of lipid metabolism and play a central role in metabolic dysfunction-associated steatotic liver disease (MASLD). In a recent issue of Molecular Cell, Nie et al. 1 have discovered that Drosha, known for microRNA processing, regulates the maturation and activation of SREBP1 in the liver, and this seems to be important in MASLD.
Purpose: The study aimed to describe patients’ experiences of physical, psychological, social, and existential symptoms and challenges during the first year after allogeneic haematopoietic cell transplantation (allo-HCT). Methods: Quantitative and qualitative data were collected and analysed with descriptive methods as part of a large retrospective cross-sectional online survey of patients who und
Emission och absorption av termiskt ljus på fotonnivå Vi visar att emission och absorption av mikrovågsfotoner från en nanostruktur i millikelvinområdet når nära 100% effektivitet. Strukturen kan fungera som en termisk fotonkälla för kvantteknologin. De senaste åren har kvantteknologi vuxit fram som ett nytt spännande forskningsfält som det just nu satsas stora resurser på, både i Sverige och inThe development of controllable thermal photon sources is essential for the advancement of quantum computers, specifically for the development of sensitive detectors and the study of heat transport in superconducting circuits. This thesis investigates a device featuring a metallic copper island acting as a variable thermal bath, coupled to a superconducting microwave line through a clean interface
Stålindustrin står för ungefär 7-8% av världens växthusgasutsläpp, och fordonsindustrin är en av dess viktigaste kunder. Fordonstillverkare som Volvo, Mercedes och Scania möter idag hårdare krav på att minska utsläppen i sina försörjningskedjor, genom regelverk i EU som förändras snabbt och ett växande tryck att ansvara för sina koldioxidavtryck. I detta sammanhang har grönt stål blivit en strategThe steel sector accounts for approximately 7-8% of global greenhouse gas (GHG) emissions, and the automotive industry stands for a large part of its customer base. As Original Equipment Manufacturers (OEMs), such as Volvo, Mercedes and Scania etc., face tightening Scope 3 emission targets, evolving EU regulatory frameworks, and growing pressure to decarbonise their supply chains, the question of
Bidraget (bokkapitlet) ger en omfattande genomgång av AI, dess historiska utveckling, definitioner och rättsliga reglering, med särskilt fokus på EU:s AI-förordning. I bidraget beskrivs hur AI har utvecklats från teoretiska modeller på 1950-talet till en central del av befintlig digital infrastruktur, med tillämpningar inom både privat och offentlig sektor, inklusive produktion, sociala medier, di
Objectives: – To evaluate the prevalence of mood disorder symptoms and measure the quality of life in women with vulvar dermatoses attending a specialized vulvar clinic in southern Sweden. Materials and Methods: – A questionnaire-based study among consecutive women attending the vulvar unit at the Department of Dermatology and Venereology at Skåne University Hospital. Sociodemographic factors were
Bladder cancer is a fast-moving and recurrent malignancy where survival hinges on early detection and precise risk stratification. The search for robust biomarkers is urgent, and CD44v6 has emerged as a compelling candidate. In this study, we explored the clinical and functional associations of CD44v6 expression in bladder cancer. Integrated analyses of patient samples and cell lines showed that h
