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Failure of transdifferentiation of adult hematopoietic stem cells into neurons.

Previous studies of bone marrow-derived stem cell transdifferentiation into neurons have not involved purified cell populations and determined their exact phenotype prior to differentiation. The present study investigates whether highly purified mouse adult hematopoietic stem cells (HSCs), characterized by lineage marker depletion and expression of the cell surface markers Sca1 and c-Kit (Lin(-)Sc

Methane yield in source-sorted organic fraction of municipal solid waste

Treating the source-separated organic fraction of municipal solid waste (SS-OFMSW) by anaerobic digestion is considered by many municipalities in Europe as an environmentally friendly means of treating organic waste and simultaneously producing methane gas. Methane yield can be used as a parameter for evaluation of the many different systems that exist for sorting and pre-treating waste. Methane y

The Greek of the Ancient Synagogue : An Investigation on the Greek of the Septuagint, Pseudepigrapha and the New Testament

This study attempts to test the hypothesis that there existed a peculiar variety of Greek which was used for certain purposes by Jewish and Christian writers in the context of the synagogue. It is argued that the origin of this variety was the translation Greek of the Pentateuch, and the background for the hypothesis is the polyglossic nature of the Greek language, i.e., several varieties were use

Intrinsic apodization effect in a compact two-mirror system with a spherical primary mirror

In so-called compact two-mirror focusing and afocal systems the secondary mirror is situated at the paraxial focus of the spherical primary mirror. The peculiar conelike shape of the secondary is chosen to eliminate the spherical aberration. Thus the systems are stigmatic, but they have a great offence against the sine condition (OSC), creating uneven distribution of energy on the surface of the o

A tephra-based correlation between the Faroe Islands and the Norwegian Sea raises questions about chronological relationships during the last interglacial

Marine ash zones from the last interglacial period have been described from cores from the North Atlantic and an ash zone from the middle part of the interglacial has been observed in connection with a major cooling event. Here we present evidence for a coeval ash zone in a terrestrial site on the Faroe Islands. The investigated sediments are correlated with the upper part of oxygen isotope stage

Survival and future need of long-term oxygen therapy for chronic obstructive pulmonary disease - gender differences

We aimed to study trends in gender-related differences in incidence, and prevalence for tong-term oxygen therapy due to chronic obstructive pulmonary disease. Another aim was to study survival after onset of oxygen therapy. Prospectively followed were 5689 Swedish patients, who were prescribed oxygen therapy because of chronic obstructive pulmonary disease from 1987 to 2000. The annual incidence o

Stationärt bofast eller på resande fot?

Kåserande artikel om skilda former av resande förr och idag, arbetsvandringar och studieresor, hantverkare och soldater. Om ovälkomna resenärer och tendensen att peka ut syndabockar, behovet av källkritik. Gunnar Ståhl: "Resenärer i arkiven". Referat av föredrag.

Suboptimal antibiotic dosage as a risk factor for selection of penicillin-resistant Streptococcus pneumoniae: In vitro kinetic model

Optimizing pharmacokinetic/pharmacodynamic indices of antibiotics to obtain clinical and microbiological efficacy is essential, but dosing regimens must also be tailored to minimize the risk for emergence of resistance. The aim of the present study was to investigate whether certain concentrations of benzylpenicillin are critical for the selection of resistant subpopulations. A mixed culture of St

Is it a sin to travel? Itinerant women in post−Soviet narrative

The cultural construction of the journey as a narrative of masculine identity poses problems for the conceptualization of the female traveller in general and of the female Russian migrant in particular. Three contemporary prose pieces dealing with women's migration reveal subtle and often sophisticated ways of playing with the stigmatization of Russian women as prostitutes and of destabilizing the

Apolipoprotein M

Apolipoprotein M (apoM) is a 26-kDa protein that is mainly associated with high-density lipoprotein (HDL) in human plasma, with a small proportion present in triglyceride-rich lipoproteins (TGRLP) and low-density lipoproteins (LDL). Human apoM gene is located in p21.31 on chromosome 6 (chromosome 17, in mouse). Human apoM cDNA (734 base pairs) encodes 188-amino acid residue-long protein. It belong

Numerical investigation of powder compaction of gear wheels

A method to judge the porosity distribution within complex powder compacted 3D structures using a dynamic 3D dilatant finite strain finite element program is presented. The method is demonstrated for a gear wheel, using a combined FKM Gurson model with parameters calibrated from experiments to model a ferrous powder. Compaction is pursued until a final average porosity of 3% in the gear. The metho