The transcription factor SOX2 is a well-established and important stem cell marker. Its role in cancer biology remains unclear, but it has been proposed to also be a marker of cancer stem cells. We investigated the role of SOX2 protein expression in women with high-grade serous ovarian cancer (HGSOC) to determine its potential prognostic and treatment predictive value. We constructed a tissue micr

Background: Oxytocin is released in response to a fatty meal. Blockage of the oxytocin receptor led to slower gastric emptying whereas stimulation resulted in less satiety in healthy volunteers. Patients with diabetes mellitus and gastroparesis lack oxytocin elevation, and dyspepsia is partly caused by reduced fundus accommodation causing early satiety and related symptoms. The aim of this study w

The World Cancer Research Fund International has concluded strong evidence for that high intake of dairy products and foods containing dietary fiber and low intake of processed meat are associated with decreased risk of colorectal cancer (CRC). As food items are consumed together, it is important to study dietary patterns. The aim of the present study was to examine the association between an a pr

The cytoplasmic protein AXIN1 is involved in the Wnt signalling pathway and its expression is increased in patients with endometriosis compared with healthy controls. The aim of the present cross-sectional study was to further assess the levels of AXIN1 and other inflamma­tory biomarkers in patients with endometriosis. Patients with laparoscopy-verified endometriosis were recruited (n=172) and com

Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations in HCC is derived mostly from case-control designs, with sparse information from prospective cohorts. Our objective was to apply comprehensive metabolite profiling to detect metabolites whose serum concentrations are associated with HCC development, using biological samples

Aims: Patients with left axis deviation (LAD) and left bundle branch block (LBBB) show less benefit from cardiac resynchronization therapy (CRT) compared to other LBBB-patients. This study investigates the reasons for this. Methods: Sixty-eight patients eligible for CRT were included. Patients were divided into groups according to QRS-axis; normal axis (NA), left axis deviation (LAD) and right axi

När kommuner satsar på sina stadskärnor och externa köpcentrum uppmuntras samtidigt konsumtion. På så sätt krockar på många sätt lokala ekonomiska mål med mer globala hållbarhetsmål.När kommuner satsar på sina stadskärnor och externa köpcentrum uppmuntras samtidigt konsumtion. På så sätt krockar på många sätt lokala ekonomiska mål med mer globala hållbarhetsmål.

The Hyogo and Sendai frameworks stress that risk assessments should inform plans. However, it is unclear how, in theory, risk assessments and plans are conceptually related and how, in practice, they inform each other. This study aims to fill this knowledge gap. Conceptually, it proposes an explicit link between risk assessments and plans via the capability of the responding organisation and its e

OBJECTIVES: Light microscopical analysis in two dimensions, combined with immunohistochemistry, is presently the gold standard to describe the enteric nervous system (ENS). Our aim was to assess the usefulness of three-dimensional (3D) imaging by X-ray phase-contrast tomography in evaluating the ENS of the human bowel.MATERIAL AND METHODS: Myenteric ganglia were identified in full-thickness biopsi

An experiment on elastic scattering of 15 C on 208 Pb at an energy of 65 MeVwas performed at ISOLDE (CERN) exploiting the advantages of the ISOL te-chinique. The measurement showed in increase of the reaction cross section to3035 mb with respect to 12 C, confirming the results obtained at 80 MeV/u. Mea-surements to characterise and develop detector modules for the CALIFA setupwas performed for the

Different scientific communities produce different kinds of datasets that rely on different data descriptions, approaches, and logical organisations. In such an environment, it is essential to establish a knowledge communication framework that can guarantee some fundamentals, such as an inclusive description and documentation of the interdisciplinary digital resources, their long-term preservation

Spatial Data Infrastructure (SDI) provides a platform for spatial data sharing and is a key for sustainable development. Developing countries, including Tanzania, are at different stages of implementing SDIs. The importance and advantage of implementation lie in the fact that considerable funds can be saved by avoiding duplication of data, and improving quality of decisions making as well as publi

This study provides an account of the introduction of care choice systems into the provision of home care by Swedish municipalities. Care choice systems in elder care are at the centre of a conflict about the broader principles of the welfare state. Studying them is thus a way of revealing the outlines of this conflict. In this thesis, I show how the introduction of care choice systems changes the

Background: Open innovation highlights the potential benefits of external collaboration and knowledge-sharing, often exemplified through Open Source Software (OSS). The public sector has thus far mainly focused on the sharing of Open Government Data (OGD), often with a supply-driven approach with limited feedback-loops. We hypothesize that public sector organizations can extend the open innovation

Breast cancer is a disease of genomic alterations, of which the panorama of somatic mutations and how these relate to subtypes and therapy response is incompletely understood. Within SCAN‐B (ClinicalTrials.gov: NCT02306096), a prospective study elucidating the transcriptomic profiles for thousands of breast cancers, we developed a RNA‐seq pipeline for detection of SNVs/indels and profiled a real‐w